How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders
Depression and anxiety commonly occur in chronic pain states and the coexistence of these diseases worsens outcomes for both disorders and may reduce treatment adherence and response. Despite the advances in the knowledge of chronic pain mechanisms, pharmacological treatment is still unsatisfactory....
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| Veröffentlicht in: | British journal of pharmacology 2022-04, Vol.179 (8), p.1640-1660 |
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| container_title | British journal of pharmacology |
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| creator | Kimura, Louise F. Novaes, Leonardo S. Picolo, Gisele Munhoz, Carolina D. Cheung, Chi W. Camarini, Rosana |
| description | Depression and anxiety commonly occur in chronic pain states and the coexistence of these diseases worsens outcomes for both disorders and may reduce treatment adherence and response. Despite the advances in the knowledge of chronic pain mechanisms, pharmacological treatment is still unsatisfactory. Research based on exposure to environmental enrichment is currently under investigation and seems to offer a promising low‐cost strategy with no side effects. In this review, we discuss the role of inflammation as a major biological substrate and aetiological factor of chronic pain and depression/anxiety and report a collection of preclinical evidence of the effects and mechanisms of environmental enrichment. As microglia participates in the development of both conditions, we also discuss microglia as a potential target underlying the beneficial actions of environmental enrichment in chronic pain and comorbid depression/anxiety. We also discuss how alternative interventions under clinical guidelines, such as environmental enrichment, may improve treatment compliance and patient outcomes.
LINKED ARTICLES
This article is part of a themed issue on Building Bridges in Neuropharmacology. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.8/issuetoc |
| doi_str_mv | 10.1111/bph.15584 |
| format | Article |
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LINKED ARTICLES
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LINKED ARTICLES
This article is part of a themed issue on Building Bridges in Neuropharmacology. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.8/issuetoc</description><subject>Anxiety</subject><subject>Anxiety disorders</subject><subject>Anxiety Disorders - therapy</subject><subject>Chronic pain</subject><subject>Chronic Pain - drug therapy</subject><subject>Coexistence</subject><subject>Comorbidity</subject><subject>depression</subject><subject>Depression - drug therapy</subject><subject>Drug therapy</subject><subject>Enrichment</subject><subject>environmental enrichment</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Mental depression</subject><subject>Microglia</subject><subject>mood disorders</subject><subject>neuroinflammation</subject><subject>Neuroinflammatory Diseases</subject><subject>Neuropharmacology</subject><subject>Pain</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EokvhwB9AlrjQQ1p_xXGOUFG2UiV6gLPlj4nWVWIHO2nZf4-3WzggdS6j1_PMq7FehN5Tck5rXdh5d07bVokXaENFJ5uWK_oSbQghXUOpUifoTSl3hNRh175GJ1yQTqqebtB-mx4wxPuQU5wgLmasKge3OwhszWiig4LTuuAIa04hDqOZJrOEFHGI2O3qYnB4NlWY6LFLU8o2eOxhzlDKgTu8m_g7wLLHPpSUPeTyFr0azFjg3VM_RT-vvv643DY3379dX36-aRxXSjRmIJIOjlLnhZCOedMNvZdt7wYpwErCDeG2A9dbY6mV0vWEMcdaYxWzQvJT9OnoO-f0a4Wy6CkUB2P9GaS1aNZyKZQQLa_ox__Qu7TmWK_TTPKeso4xUamzI-VyKiXDoOccJpP3mhJ9yEPXPPRjHpX98OS42gn8P_JvABW4OAIPYYT98076y-32aPkH9n-W7w</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Kimura, Louise F.</creator><creator>Novaes, Leonardo S.</creator><creator>Picolo, Gisele</creator><creator>Munhoz, Carolina D.</creator><creator>Cheung, Chi W.</creator><creator>Camarini, Rosana</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8739-509X</orcidid><orcidid>https://orcid.org/0000-0002-8131-6108</orcidid><orcidid>https://orcid.org/0000-0002-8656-5234</orcidid></search><sort><creationdate>202204</creationdate><title>How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders</title><author>Kimura, Louise F. ; 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Despite the advances in the knowledge of chronic pain mechanisms, pharmacological treatment is still unsatisfactory. Research based on exposure to environmental enrichment is currently under investigation and seems to offer a promising low‐cost strategy with no side effects. In this review, we discuss the role of inflammation as a major biological substrate and aetiological factor of chronic pain and depression/anxiety and report a collection of preclinical evidence of the effects and mechanisms of environmental enrichment. As microglia participates in the development of both conditions, we also discuss microglia as a potential target underlying the beneficial actions of environmental enrichment in chronic pain and comorbid depression/anxiety. We also discuss how alternative interventions under clinical guidelines, such as environmental enrichment, may improve treatment compliance and patient outcomes.
LINKED ARTICLES
This article is part of a themed issue on Building Bridges in Neuropharmacology. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.8/issuetoc</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>34076891</pmid><doi>10.1111/bph.15584</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0001-8739-509X</orcidid><orcidid>https://orcid.org/0000-0002-8131-6108</orcidid><orcidid>https://orcid.org/0000-0002-8656-5234</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anxiety Anxiety disorders Anxiety Disorders - therapy Chronic pain Chronic Pain - drug therapy Coexistence Comorbidity depression Depression - drug therapy Drug therapy Enrichment environmental enrichment Humans Inflammation Mental depression Microglia mood disorders neuroinflammation Neuroinflammatory Diseases Neuropharmacology Pain |
| title | How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders |
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