FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1β signaling pathway in mice and macrophages

Objective Asthma, a well-known disease with high morbidity, is characterized by chronic airway inflammation. However, the allergic inflammation mechanisms of follistatin-like protein 1 (FSTL1) have not been elucidated. This study aims to investigate the effects of FSTL1 in ovalbumin (OVA)-induced mi...

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Veröffentlicht in:	Inflammation research 2021-07, Vol.70 (7), p.777-787
Hauptverfasser:	Wang, Yan, Zhang, Dong, Liu, Tian, Wang, Jun-fei, Wu, Jin-xiang, Zhao, Ji-ping, Xu, Jia-wei, Zhang, Jin-tao, Dong, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Allergens - immunology Allergology Alveoli Animals Asthma Asthma - blood Asthma - immunology Biomedical and Life Sciences Biomedicine Bronchoalveolar Lavage Fluid - immunology Bronchus Cell Line Chemical compounds Cytokines Cytokines - immunology Dermatology Enzyme-linked immunosorbent assay Female Follistatin Follistatin-Related Proteins - genetics Follistatin-Related Proteins - immunology Furans - pharmacology Humans Hypersensitivity IL-1β Immunohistochemistry Immunology Indenes - pharmacology Inflammation Interleukins Leucine Lung - immunology Macrophages Macrophages - immunology Male Mice Mice, Inbred C57BL Middle Aged Morbidity Neurology NLR Family, Pyrin Domain-Containing 3 Protein - immunology Nucleotides Original Research Paper Ovalbumin Ovalbumin - immunology Pharmacology Pharmacology/Toxicology Pretreatment Proteins Respiratory tract Respiratory tract diseases Rheumatology Signal Transduction Signaling Sulfonamides - pharmacology
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