Corilagin ameliorates atherosclerosis by regulating MMP-1, -2, and -9 expression in vitro and in vivo

Corilagin is a polyphenol has been identified anti-inflammatory properties. However, the anti-atherosclerotic effects of corilagin are not well understood. Here, we evaluated the anti-atherosclerotic effects and the underlying mechanisms of corilagin. We also verified whether corilagin can reverse a...

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Veröffentlicht in:	European journal of pharmacology 2021-09, Vol.906, p.174200-174200, Article 174200
Hauptverfasser:	Tao, Yiting, Zhang, Li, Yang, Renhua, Yang, Yongzhao, Jin, Haonan, Zhang, Xiaochao, Hu, Qin, He, Bo, Shen, Zhiqiang, Chen, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - etiology Atherosclerosis - pathology Carotid Artery, Common - drug effects Carotid Artery, Common - metabolism Carotid Artery, Common - pathology Corilagin Diet, High-Fat - adverse effects Disease Models, Animal Glucosides - pharmacology Glucosides - therapeutic use Humans Hydrolyzable Tannins - pharmacology Hydrolyzable Tannins - therapeutic use Male Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors - pharmacology Matrix Metalloproteinase Inhibitors - therapeutic use Mice Minipig MMP-1, -2, -9 NF-κB Oxidized low-density lipoprotein RAW 264.7 Cells Swine Swine, Miniature
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