miR‐506‐loaded gelatin nanospheres target PENK and inactivate the ERK/Fos signaling pathway to suppress triple‐negative breast cancer aggressiveness

Triple‐negative breast cancer (TNBC) is the most malignant subtype of breast cancer. Some microRNAs (miRNAs) were abnormally expressed in TNBC, and they are closely related to the occurrence and progression of TNBC. Here, we found that miR‐506 was significantly downregulated in TNBC and relatively l...

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Veröffentlicht in:	Molecular carcinogenesis 2021-08, Vol.60 (8), p.538-555
Hauptverfasser:	Liu, Xin‐Li, Liu, Wen‐Jing, Chen, Qiang, Liu, Jie, Yang, Chang‐Qing, Zhang, Ge, Zhang, Shi‐Long, Guo, Wei‐Hong, Li, Jing‐Bao, Zhao, Gang, Yin, Da‐Chuan, Zhang, Chen‐Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	aggressiveness Animal models Breast cancer Cell migration Cell viability Controlled release Extracellular signal-regulated kinase Gelatin gelatin nanospheres Metastases MicroRNAs miRNA miR‐506 PENK Proenkephalin Signal transduction triple‐negative breast cancer Xenografts
Online-Zugang:	Volltext
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