Chemometric evaluation of repeatability of internal standard methods in high-performance liquid chromatography with a Japanese pharmacopoeia assay for indomethacin as an example

•Uncertainty structures of internal standard (IS) method were elucidated.•In IS methods, precision profiles were obtained by applying the FUMI theory.•Statistical advantages of IS methods were experimentally and theoretically demonstrated.•An acceptable lower limit of IS amounts can be found from pr...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2021-08, Vol.202, p.114165-114165, Article 114165
Hauptverfasser:	Kotani, Akira, Hakamata, Hideki, Hayashi, Yuzuru
Format:	Artikel
Sprache:	eng
Schlagworte:	FUMI theory Injection volume Internal standard method Liquid chromatography Relative standard deviation
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