Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation

Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas with poor prognosis, developing either sporadically or in persons with neurofibromatosis type 1 (NF1). Loss of CDKN2A/B is an important early event in MPNST progression. However, many reported MPNSTs exhibit partial...

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Veröffentlicht in:	Human genetics 2021-08, Vol.140 (8), p.1241-1252
Hauptverfasser:	Magallón-Lorenz, Miriam, Fernández-Rodríguez, Juana, Terribas, Ernest, Creus-Batchiller, Edgar, Romagosa, Cleofe, Estival, Anna, Perez Sidelnikova, Diana, Salvador, Héctor, Villanueva, Alberto, Blanco, Ignacio, Carrió, Meritxell, Lázaro, Conxi, Serra, Eduard, Gel, Bernat
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biomedical and Life Sciences Biomedicine Breakpoints Chromosome translocations DNA sequencing Gene Function Gene mutations Genetic disorders Genomic analysis Human Genetics Metabolic Diseases Molecular Medicine Neurofibromatosis Neurological disorders Nucleotide sequencing Original Investigation Peripheral nerves Prognosis Recklinghausen's disease Sarcoma Tumors
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