cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7

We aimed to investigate the role of cMet agonistic antibody (cMet Ab) in preventing kidney fibrosis during acute kidney injury (AKI) to chronic kidney disease (CKD) transition. Additionally, we explored the effect of cMet Ab on TGF-β1/Smad pathway during the pathogenesis of kidney fibrosis. A unilat...

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Veröffentlicht in:	Clinical science (1979) 2021-06, Vol.135 (11), p.1427-1444
Hauptverfasser:	Li, Lilin, Lee, Jeonghwan, Cho, Ara, Kim, Jin Hyuk, Ju, Wonmin, An, Jung Nam, Park, Jeong Hwan, Zhu, Shi Mao, Lee, Junghun, Yu, Seung-Shin, Lim, Chun Soo, Kim, Dong Ki, Kim, Yon Su, Yang, Seung Hee, Lee, Jung Pyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Animals Fibrosis - pathology Humans Kidney - metabolism Mice Mice, Inbred C57BL Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Reperfusion Injury - metabolism Reperfusion Injury - pathology Smad7 Protein - metabolism Transforming Growth Factor beta - metabolism
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