Can the CT by‐product Time to threshold be a prognostic factor in patients with acute pulmonary embolism?
Introduction Bolus tracking is applied in computed tomography pulmonary angiography. The time that it takes for contrast to reach a predefined threshold in the pulmonary artery is called time to threshold (TTT). Our purpose was to analyse possible associations between TTT and circulatory state and p...
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| Veröffentlicht in: | Journal of medical imaging and radiation oncology 2021-12, Vol.65 (7), p.846-849 |
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| creator | Meyer, Hans‐Jonas Bailis, Nikolaos Surov, Alexey |
| description | Introduction
Bolus tracking is applied in computed tomography pulmonary angiography. The time that it takes for contrast to reach a predefined threshold in the pulmonary artery is called time to threshold (TTT). Our purpose was to analyse possible associations between TTT and circulatory state and prognosis in patients with acute pulmonary embolism (PE).
Methods
In a single‐centre, retrospective study 138 patients with PE and contrast administration via peripheral venous line were included. Clinical parameters of circulatory state were arterial pH, systolic blood pressure, heart rate, sPESI score, Wells score and GENEVA score. Survival was defined as surviving the following 30 days after the PE diagnosis.
Results
Time to threshold was only weakly correlated with Fi02 (r = 0.26, P = 0.04), pH (r = −0.22, P = 0.009), venous base excess (r = −0.18, P = 0.04) and venous lactate (r = 0.21, P = 0.01). TTT did not correlate with clinical parameters/scores and mortality. There were weak associations between TTT and blood gas analysis parameters. There were no associations with clinically relevant prognosis scores and overall survival.
Conclusion
Therefore, albeit TTT is an easily assessable parameter of CTPA, the potential use in clinical routine is limited for prognosis stratification in patients with PE. |
| doi_str_mv | 10.1111/1754-9485.13246 |
| format | Article |
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Bolus tracking is applied in computed tomography pulmonary angiography. The time that it takes for contrast to reach a predefined threshold in the pulmonary artery is called time to threshold (TTT). Our purpose was to analyse possible associations between TTT and circulatory state and prognosis in patients with acute pulmonary embolism (PE).
Methods
In a single‐centre, retrospective study 138 patients with PE and contrast administration via peripheral venous line were included. Clinical parameters of circulatory state were arterial pH, systolic blood pressure, heart rate, sPESI score, Wells score and GENEVA score. Survival was defined as surviving the following 30 days after the PE diagnosis.
Results
Time to threshold was only weakly correlated with Fi02 (r = 0.26, P = 0.04), pH (r = −0.22, P = 0.009), venous base excess (r = −0.18, P = 0.04) and venous lactate (r = 0.21, P = 0.01). TTT did not correlate with clinical parameters/scores and mortality. There were weak associations between TTT and blood gas analysis parameters. There were no associations with clinically relevant prognosis scores and overall survival.
Conclusion
Therefore, albeit TTT is an easily assessable parameter of CTPA, the potential use in clinical routine is limited for prognosis stratification in patients with PE.</description><identifier>ISSN: 1754-9477</identifier><identifier>EISSN: 1754-9485</identifier><identifier>DOI: 10.1111/1754-9485.13246</identifier><language>eng</language><publisher>Richmond: Wiley Subscription Services, Inc</publisher><subject>Angiography ; Blood gas analysis ; Blood pressure ; Computed tomography ; Embolisms ; Gas analysis ; Heart rate ; Medical prognosis ; Parameters ; Prognosis ; Pulmonary arteries ; pulmonary embolism ; Pulmonary embolisms ; Survival ; time to threshold</subject><ispartof>Journal of medical imaging and radiation oncology, 2021-12, Vol.65 (7), p.846-849</ispartof><rights>2021 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Radiologists.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3026-f83519b542e8829635e218d41e25c6db49b7231826ee6499c2f77ea291f460693</cites><orcidid>0000-0001-8489-706X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1754-9485.13246$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1754-9485.13246$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids></links><search><creatorcontrib>Meyer, Hans‐Jonas</creatorcontrib><creatorcontrib>Bailis, Nikolaos</creatorcontrib><creatorcontrib>Surov, Alexey</creatorcontrib><title>Can the CT by‐product Time to threshold be a prognostic factor in patients with acute pulmonary embolism?</title><title>Journal of medical imaging and radiation oncology</title><description>Introduction
Bolus tracking is applied in computed tomography pulmonary angiography. The time that it takes for contrast to reach a predefined threshold in the pulmonary artery is called time to threshold (TTT). Our purpose was to analyse possible associations between TTT and circulatory state and prognosis in patients with acute pulmonary embolism (PE).
Methods
In a single‐centre, retrospective study 138 patients with PE and contrast administration via peripheral venous line were included. Clinical parameters of circulatory state were arterial pH, systolic blood pressure, heart rate, sPESI score, Wells score and GENEVA score. Survival was defined as surviving the following 30 days after the PE diagnosis.
Results
Time to threshold was only weakly correlated with Fi02 (r = 0.26, P = 0.04), pH (r = −0.22, P = 0.009), venous base excess (r = −0.18, P = 0.04) and venous lactate (r = 0.21, P = 0.01). TTT did not correlate with clinical parameters/scores and mortality. There were weak associations between TTT and blood gas analysis parameters. There were no associations with clinically relevant prognosis scores and overall survival.
Conclusion
Therefore, albeit TTT is an easily assessable parameter of CTPA, the potential use in clinical routine is limited for prognosis stratification in patients with PE.</description><subject>Angiography</subject><subject>Blood gas analysis</subject><subject>Blood pressure</subject><subject>Computed tomography</subject><subject>Embolisms</subject><subject>Gas analysis</subject><subject>Heart rate</subject><subject>Medical prognosis</subject><subject>Parameters</subject><subject>Prognosis</subject><subject>Pulmonary arteries</subject><subject>pulmonary embolism</subject><subject>Pulmonary embolisms</subject><subject>Survival</subject><subject>time to threshold</subject><issn>1754-9477</issn><issn>1754-9485</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqFkL9OwzAQxiMEEqUws1piYWkbO7YTT6iq-CdVQkJlthznQl2SOMSOqm48As_Ik-AS1IGFW-509_tOd18UXeJ4ikPMcMroRNCMTXFCKD-KRofO8aFO09PozLlNHHOMqRhFbwvVIL8GtFihfPf18dl2tui1RytTA_I2zDpwa1sVKAekUBi_NtZ5o1GptLcdMg1qlTfQeIe2xq-R0r0H1PZVbRvV7RDUua2Mq2_Oo5NSVQ4ufvM4erm7XS0eJsun-8fFfDnRSUz4pMwShkXOKIEsI4InDAjOCoqBMM2LnIo8JQnOCAfgVAhNyjQFRQQuKY-5SMbR9bA3HPveg_OyNk5DVakGbO8kYQkLi2OKA3r1B93YvmvCdZLwOBWUCZYFajZQurPOdVDKtjN1-E3iWO7Nl3t75d5q-WN-ULBBsTUV7P7D5fx5Pui-AbQxhbs</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Meyer, Hans‐Jonas</creator><creator>Bailis, Nikolaos</creator><creator>Surov, Alexey</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8489-706X</orcidid></search><sort><creationdate>202112</creationdate><title>Can the CT by‐product Time to threshold be a prognostic factor in patients with acute pulmonary embolism?</title><author>Meyer, Hans‐Jonas ; Bailis, Nikolaos ; Surov, Alexey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3026-f83519b542e8829635e218d41e25c6db49b7231826ee6499c2f77ea291f460693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Angiography</topic><topic>Blood gas analysis</topic><topic>Blood pressure</topic><topic>Computed tomography</topic><topic>Embolisms</topic><topic>Gas analysis</topic><topic>Heart rate</topic><topic>Medical prognosis</topic><topic>Parameters</topic><topic>Prognosis</topic><topic>Pulmonary arteries</topic><topic>pulmonary embolism</topic><topic>Pulmonary embolisms</topic><topic>Survival</topic><topic>time to threshold</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyer, Hans‐Jonas</creatorcontrib><creatorcontrib>Bailis, Nikolaos</creatorcontrib><creatorcontrib>Surov, Alexey</creatorcontrib><collection>Wiley-Blackwell Open Access Collection</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical imaging and radiation oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyer, Hans‐Jonas</au><au>Bailis, Nikolaos</au><au>Surov, Alexey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can the CT by‐product Time to threshold be a prognostic factor in patients with acute pulmonary embolism?</atitle><jtitle>Journal of medical imaging and radiation oncology</jtitle><date>2021-12</date><risdate>2021</risdate><volume>65</volume><issue>7</issue><spage>846</spage><epage>849</epage><pages>846-849</pages><issn>1754-9477</issn><eissn>1754-9485</eissn><abstract>Introduction
Bolus tracking is applied in computed tomography pulmonary angiography. The time that it takes for contrast to reach a predefined threshold in the pulmonary artery is called time to threshold (TTT). Our purpose was to analyse possible associations between TTT and circulatory state and prognosis in patients with acute pulmonary embolism (PE).
Methods
In a single‐centre, retrospective study 138 patients with PE and contrast administration via peripheral venous line were included. Clinical parameters of circulatory state were arterial pH, systolic blood pressure, heart rate, sPESI score, Wells score and GENEVA score. Survival was defined as surviving the following 30 days after the PE diagnosis.
Results
Time to threshold was only weakly correlated with Fi02 (r = 0.26, P = 0.04), pH (r = −0.22, P = 0.009), venous base excess (r = −0.18, P = 0.04) and venous lactate (r = 0.21, P = 0.01). TTT did not correlate with clinical parameters/scores and mortality. There were weak associations between TTT and blood gas analysis parameters. There were no associations with clinically relevant prognosis scores and overall survival.
Conclusion
Therefore, albeit TTT is an easily assessable parameter of CTPA, the potential use in clinical routine is limited for prognosis stratification in patients with PE.</abstract><cop>Richmond</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/1754-9485.13246</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-8489-706X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | Angiography Blood gas analysis Blood pressure Computed tomography Embolisms Gas analysis Heart rate Medical prognosis Parameters Prognosis Pulmonary arteries pulmonary embolism Pulmonary embolisms Survival time to threshold |
| title | Can the CT by‐product Time to threshold be a prognostic factor in patients with acute pulmonary embolism? |
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