Combining modeling of drug uptake and release of cyclosporine in contact lenses to determine partition coefficient and diffusivity

Ophthalmic drug delivery via eye drops is inefficient because only about 1-5% of the drug permeates the cornea during the short residence time of a few minutes. Contact lenses are receiving considerable attention for delivering ophthalmic drugs because of higher bioavailability and the possibility o...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2021-09, Vol.164, p.105891-105891, Article 105891
Hauptverfasser:	Lanier, Olivia L., Manfre, Miranda, Kulkarni, Sandesh, Bailey, Claire, Chauhan, Anuj
Format:	Artikel
Sprache:	eng
Schlagworte:	Contact lenses Cyclosporine Diffusivity Drug delivery Finite difference fitting methods Partition coefficient Vitamin E
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