Kinetics of emergence of liver complications in hepatitis C virus infected patients and advanced fibrosis, with and without HIV-coinfection, after sustained virological response

OBJECTIVEThere is scarce available evidence on the distribution over time of liver complications emergence in hepatitis C virus (HCV)-infected patients who achieve sustained virological response (SVR) with direct-acting antiviral (DAA)-based therapy. Therefore, we aimed at describing the kinetics of...

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Veröffentlicht in:AIDS (London) 2021-11, Vol.35 (13), p.2119-2127
Hauptverfasser: Corma-Gómez, Anaïs, Macías, Juan, Téllez, Francisco, Morano, Luis, Rivero, Antonio, Serrano, Miriam, Ríos, María José, Vera-Méndez, Francisco Jesús, Santos, Marta, Real, Luis Miguel, Palacios, Rosario, Santos, Ignacio de Los, Geijo, Paloma, Imaz, Arkaitz, Merino, Dolores, Galindo, Maria José, Reus-Bañuls, Sergio, López-Ruz, Miguel Ángel, Galera, Carlos, Pineda, Juan A.
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container_end_page 2127
container_issue 13
container_start_page 2119
container_title AIDS (London)
container_volume 35
creator Corma-Gómez, Anaïs
Macías, Juan
Téllez, Francisco
Morano, Luis
Rivero, Antonio
Serrano, Miriam
Ríos, María José
Vera-Méndez, Francisco Jesús
Santos, Marta
Real, Luis Miguel
Palacios, Rosario
Santos, Ignacio de Los
Geijo, Paloma
Imaz, Arkaitz
Merino, Dolores
Galindo, Maria José
Reus-Bañuls, Sergio
López-Ruz, Miguel Ángel
Galera, Carlos
Pineda, Juan A.
description OBJECTIVEThere is scarce available evidence on the distribution over time of liver complications emergence in hepatitis C virus (HCV)-infected patients who achieve sustained virological response (SVR) with direct-acting antiviral (DAA)-based therapy. Therefore, we aimed at describing the kinetics of liver-related events appearance in this setting. DESIGNA multicentric prospective cohort study. METHODSHCV-monoinfected and HIV/HCV-coinfected patients from GEHEP-011 cohort, whose inclusion criteria were had achieved SVR with DAA-based therapy; liver stiffness prior to starting treatment at least 9.5 kPa; and available liver stiffness measurement at SVR. SVR was considered as the baseline time-point. RESULTSOne thousand and thirty-five patients were included, 664 (64%) coinfected with HIV. Before DAA-based therapy, 63 (6.1%) individuals showed decompensated cirrhosis. After SVR, 51 (4.9%) patients developed liver complications. Median (Q1-Q3) time to the emergence of hepatic events was hepatic encephalopathy 11 (7-24) months, ascites 14 (6-29) months, hepatocellular carcinoma (HCC) 17 (11-42) months and portal hypertension gastrointestinal bleeding (PHGB) 28 (22-38) months (P = 0.152). We define two profiles of liver complications: those emerging earlier (encephalopathy and ascites) and, those occurring continuously during the follow-up (HCC, PHGB) [median (Q1-Q3) time to emergence 12.7 (6.6-28.2) months vs. 25.4 (12.5-41.53) months, respectively (P = 0.026)]. CONCLUSIONThe vast majority of HCV-infected patients who develop liver complications after reaching SVR with DAA do it within 3 years after SVR time-point. Specifically, hepatic encephalopathy and ascites do not usually emerge after this period. Conversely, HCC and PHGB may occur in longer term. It is critical to identify patients at risk of developing hepatic events to continue performing surveillance for them.
doi_str_mv 10.1097/QAD.0000000000002959
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Therefore, we aimed at describing the kinetics of liver-related events appearance in this setting. DESIGNA multicentric prospective cohort study. METHODSHCV-monoinfected and HIV/HCV-coinfected patients from GEHEP-011 cohort, whose inclusion criteria were had achieved SVR with DAA-based therapy; liver stiffness prior to starting treatment at least 9.5 kPa; and available liver stiffness measurement at SVR. SVR was considered as the baseline time-point. RESULTSOne thousand and thirty-five patients were included, 664 (64%) coinfected with HIV. Before DAA-based therapy, 63 (6.1%) individuals showed decompensated cirrhosis. After SVR, 51 (4.9%) patients developed liver complications. Median (Q1-Q3) time to the emergence of hepatic events was hepatic encephalopathy 11 (7-24) months, ascites 14 (6-29) months, hepatocellular carcinoma (HCC) 17 (11-42) months and portal hypertension gastrointestinal bleeding (PHGB) 28 (22-38) months (P = 0.152). We define two profiles of liver complications: those emerging earlier (encephalopathy and ascites) and, those occurring continuously during the follow-up (HCC, PHGB) [median (Q1-Q3) time to emergence 12.7 (6.6-28.2) months vs. 25.4 (12.5-41.53) months, respectively (P = 0.026)]. CONCLUSIONThe vast majority of HCV-infected patients who develop liver complications after reaching SVR with DAA do it within 3 years after SVR time-point. Specifically, hepatic encephalopathy and ascites do not usually emerge after this period. Conversely, HCC and PHGB may occur in longer term. It is critical to identify patients at risk of developing hepatic events to continue performing surveillance for them.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000002959</identifier><language>eng</language><publisher>Lippincott Williams &amp; Wilkins</publisher><ispartof>AIDS (London), 2021-11, Vol.35 (13), p.2119-2127</ispartof><rights>Lippincott Williams &amp; Wilkins</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3296-1606fdf01ee44c3b794711e2efb502b80d8ad217ead9f4326cb30c9f717abcc43</citedby><cites>FETCH-LOGICAL-c3296-1606fdf01ee44c3b794711e2efb502b80d8ad217ead9f4326cb30c9f717abcc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Corma-Gómez, Anaïs</creatorcontrib><creatorcontrib>Macías, Juan</creatorcontrib><creatorcontrib>Téllez, Francisco</creatorcontrib><creatorcontrib>Morano, Luis</creatorcontrib><creatorcontrib>Rivero, Antonio</creatorcontrib><creatorcontrib>Serrano, Miriam</creatorcontrib><creatorcontrib>Ríos, María José</creatorcontrib><creatorcontrib>Vera-Méndez, Francisco Jesús</creatorcontrib><creatorcontrib>Santos, Marta</creatorcontrib><creatorcontrib>Real, Luis Miguel</creatorcontrib><creatorcontrib>Palacios, Rosario</creatorcontrib><creatorcontrib>Santos, Ignacio de Los</creatorcontrib><creatorcontrib>Geijo, Paloma</creatorcontrib><creatorcontrib>Imaz, Arkaitz</creatorcontrib><creatorcontrib>Merino, Dolores</creatorcontrib><creatorcontrib>Galindo, Maria José</creatorcontrib><creatorcontrib>Reus-Bañuls, Sergio</creatorcontrib><creatorcontrib>López-Ruz, Miguel Ángel</creatorcontrib><creatorcontrib>Galera, Carlos</creatorcontrib><creatorcontrib>Pineda, Juan A.</creatorcontrib><title>Kinetics of emergence of liver complications in hepatitis C virus infected patients and advanced fibrosis, with and without HIV-coinfection, after sustained virological response</title><title>AIDS (London)</title><description>OBJECTIVEThere is scarce available evidence on the distribution over time of liver complications emergence in hepatitis C virus (HCV)-infected patients who achieve sustained virological response (SVR) with direct-acting antiviral (DAA)-based therapy. Therefore, we aimed at describing the kinetics of liver-related events appearance in this setting. DESIGNA multicentric prospective cohort study. METHODSHCV-monoinfected and HIV/HCV-coinfected patients from GEHEP-011 cohort, whose inclusion criteria were had achieved SVR with DAA-based therapy; liver stiffness prior to starting treatment at least 9.5 kPa; and available liver stiffness measurement at SVR. SVR was considered as the baseline time-point. RESULTSOne thousand and thirty-five patients were included, 664 (64%) coinfected with HIV. Before DAA-based therapy, 63 (6.1%) individuals showed decompensated cirrhosis. After SVR, 51 (4.9%) patients developed liver complications. Median (Q1-Q3) time to the emergence of hepatic events was hepatic encephalopathy 11 (7-24) months, ascites 14 (6-29) months, hepatocellular carcinoma (HCC) 17 (11-42) months and portal hypertension gastrointestinal bleeding (PHGB) 28 (22-38) months (P = 0.152). We define two profiles of liver complications: those emerging earlier (encephalopathy and ascites) and, those occurring continuously during the follow-up (HCC, PHGB) [median (Q1-Q3) time to emergence 12.7 (6.6-28.2) months vs. 25.4 (12.5-41.53) months, respectively (P = 0.026)]. CONCLUSIONThe vast majority of HCV-infected patients who develop liver complications after reaching SVR with DAA do it within 3 years after SVR time-point. Specifically, hepatic encephalopathy and ascites do not usually emerge after this period. Conversely, HCC and PHGB may occur in longer term. It is critical to identify patients at risk of developing hepatic events to continue performing surveillance for them.</description><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdUU1P3DAQtaoidQv8Aw4-9kCoP5I4PqLtB6hICAm4Ro49Zg3eOLWdXfVn9R_WYStR1ZfxzLx5b0YPoTNKLiiR4vPd5ZcL8s9jspHv0IrWgldNI-h7tCKslZXkgnxAH1N6LqCGdN0K_f7hRshOJxwshi3EJxg1LIl3O4hYh-3knVbZhTFhN-INTCXJLuE13rk4L0ULOoPBSwPGnLAaDVZmpwqTwdYNMSSXzvHe5c1rb_mEOeOr68dKh8N84T_HyuaimeaUVVnLLALBh6ei73GENJUd4AQdWeUTnP6Nx-jh29f79VV1c_v9en15U2nOZFvRlrTWWEIB6lrzQchaUAoM7NAQNnTEdMowKkAZaWvOWj1woqUVVKhB65ofo08H3imGnzOk3G9d0uC9GiHMqWcNr1sqmq4r0PoA1eXSFMH2U3RbFX_1lPSLQ31xqP_fobexffDl7vTi5z3EfgPK580rnBFOKkYYpZRQUi2llv8BvSSX_g</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Corma-Gómez, Anaïs</creator><creator>Macías, Juan</creator><creator>Téllez, Francisco</creator><creator>Morano, Luis</creator><creator>Rivero, Antonio</creator><creator>Serrano, Miriam</creator><creator>Ríos, María José</creator><creator>Vera-Méndez, Francisco Jesús</creator><creator>Santos, Marta</creator><creator>Real, Luis Miguel</creator><creator>Palacios, Rosario</creator><creator>Santos, Ignacio de Los</creator><creator>Geijo, Paloma</creator><creator>Imaz, Arkaitz</creator><creator>Merino, Dolores</creator><creator>Galindo, Maria José</creator><creator>Reus-Bañuls, Sergio</creator><creator>López-Ruz, Miguel Ángel</creator><creator>Galera, Carlos</creator><creator>Pineda, Juan A.</creator><general>Lippincott Williams &amp; Wilkins</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20211101</creationdate><title>Kinetics of emergence of liver complications in hepatitis C virus infected patients and advanced fibrosis, with and without HIV-coinfection, after sustained virological response</title><author>Corma-Gómez, Anaïs ; Macías, Juan ; Téllez, Francisco ; Morano, Luis ; Rivero, Antonio ; Serrano, Miriam ; Ríos, María José ; Vera-Méndez, Francisco Jesús ; Santos, Marta ; Real, Luis Miguel ; Palacios, Rosario ; Santos, Ignacio de Los ; Geijo, Paloma ; Imaz, Arkaitz ; Merino, Dolores ; Galindo, Maria José ; Reus-Bañuls, Sergio ; López-Ruz, Miguel Ángel ; Galera, Carlos ; Pineda, Juan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3296-1606fdf01ee44c3b794711e2efb502b80d8ad217ead9f4326cb30c9f717abcc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corma-Gómez, Anaïs</creatorcontrib><creatorcontrib>Macías, Juan</creatorcontrib><creatorcontrib>Téllez, Francisco</creatorcontrib><creatorcontrib>Morano, Luis</creatorcontrib><creatorcontrib>Rivero, Antonio</creatorcontrib><creatorcontrib>Serrano, Miriam</creatorcontrib><creatorcontrib>Ríos, María José</creatorcontrib><creatorcontrib>Vera-Méndez, Francisco Jesús</creatorcontrib><creatorcontrib>Santos, Marta</creatorcontrib><creatorcontrib>Real, Luis Miguel</creatorcontrib><creatorcontrib>Palacios, Rosario</creatorcontrib><creatorcontrib>Santos, Ignacio de Los</creatorcontrib><creatorcontrib>Geijo, Paloma</creatorcontrib><creatorcontrib>Imaz, Arkaitz</creatorcontrib><creatorcontrib>Merino, Dolores</creatorcontrib><creatorcontrib>Galindo, Maria José</creatorcontrib><creatorcontrib>Reus-Bañuls, Sergio</creatorcontrib><creatorcontrib>López-Ruz, Miguel Ángel</creatorcontrib><creatorcontrib>Galera, Carlos</creatorcontrib><creatorcontrib>Pineda, Juan A.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corma-Gómez, Anaïs</au><au>Macías, Juan</au><au>Téllez, Francisco</au><au>Morano, Luis</au><au>Rivero, Antonio</au><au>Serrano, Miriam</au><au>Ríos, María José</au><au>Vera-Méndez, Francisco Jesús</au><au>Santos, Marta</au><au>Real, Luis Miguel</au><au>Palacios, Rosario</au><au>Santos, Ignacio de Los</au><au>Geijo, Paloma</au><au>Imaz, Arkaitz</au><au>Merino, Dolores</au><au>Galindo, Maria José</au><au>Reus-Bañuls, Sergio</au><au>López-Ruz, Miguel Ángel</au><au>Galera, Carlos</au><au>Pineda, Juan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinetics of emergence of liver complications in hepatitis C virus infected patients and advanced fibrosis, with and without HIV-coinfection, after sustained virological response</atitle><jtitle>AIDS (London)</jtitle><date>2021-11-01</date><risdate>2021</risdate><volume>35</volume><issue>13</issue><spage>2119</spage><epage>2127</epage><pages>2119-2127</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>OBJECTIVEThere is scarce available evidence on the distribution over time of liver complications emergence in hepatitis C virus (HCV)-infected patients who achieve sustained virological response (SVR) with direct-acting antiviral (DAA)-based therapy. Therefore, we aimed at describing the kinetics of liver-related events appearance in this setting. DESIGNA multicentric prospective cohort study. METHODSHCV-monoinfected and HIV/HCV-coinfected patients from GEHEP-011 cohort, whose inclusion criteria were had achieved SVR with DAA-based therapy; liver stiffness prior to starting treatment at least 9.5 kPa; and available liver stiffness measurement at SVR. SVR was considered as the baseline time-point. RESULTSOne thousand and thirty-five patients were included, 664 (64%) coinfected with HIV. Before DAA-based therapy, 63 (6.1%) individuals showed decompensated cirrhosis. After SVR, 51 (4.9%) patients developed liver complications. Median (Q1-Q3) time to the emergence of hepatic events was hepatic encephalopathy 11 (7-24) months, ascites 14 (6-29) months, hepatocellular carcinoma (HCC) 17 (11-42) months and portal hypertension gastrointestinal bleeding (PHGB) 28 (22-38) months (P = 0.152). We define two profiles of liver complications: those emerging earlier (encephalopathy and ascites) and, those occurring continuously during the follow-up (HCC, PHGB) [median (Q1-Q3) time to emergence 12.7 (6.6-28.2) months vs. 25.4 (12.5-41.53) months, respectively (P = 0.026)]. CONCLUSIONThe vast majority of HCV-infected patients who develop liver complications after reaching SVR with DAA do it within 3 years after SVR time-point. Specifically, hepatic encephalopathy and ascites do not usually emerge after this period. Conversely, HCC and PHGB may occur in longer term. It is critical to identify patients at risk of developing hepatic events to continue performing surveillance for them.</abstract><pub>Lippincott Williams &amp; Wilkins</pub><doi>10.1097/QAD.0000000000002959</doi><tpages>9</tpages></addata></record>
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title Kinetics of emergence of liver complications in hepatitis C virus infected patients and advanced fibrosis, with and without HIV-coinfection, after sustained virological response
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