Role of Yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis

•Matrix stiffness is a necessary step for the perpetuation of fibrosis and malignancy.•Yes-associated protein as mechanical transducers promote the migratory phenotype.•Matrix stiffness mediate malignant transformation by the senescence escape pathway.•Reprogramming of stiff matrix restore fibrosis-...

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Veröffentlicht in:	Archives of oral biology 2021-08, Vol.128, p.105164-105164, Article 105164
Hauptverfasser:	Sharma, Mohit, Hunter, Keith D., Fonseca, Felipe Paiva, Shetty, Smitha Sammith, Radhakrishnan, Raghu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cellular senescence Dentistry Hippo pathway Matrix stiffness Oral cancer Oral submucous fibrosis
Online-Zugang:	Volltext
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