Independent and opposing associations of dietary phytosterols intake and PLCE1 rs2274223 polymorphisms on esophageal squamous cell carcinoma risk
Purpose This study was to evaluate the associations of dietary intake of total and specific phytosterols and risk of esophageal squamous cell carcinoma (ESCC) and to explore their joint effects with PLCE1 rs2274223 polymorphisms. Methods A population-based case–control study was conducted in a Chine...
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| Veröffentlicht in: | European journal of nutrition 2021-12, Vol.60 (8), p.4357-4366 |
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| container_title | European journal of nutrition |
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| creator | Wang, Shuyi Zhao, Wenjing Sun, Liping Xiao, Su-Mei Lin, Sihao Zhao, Jin Xiao, Hengyi Xing, Xiangbin Lao, Xiang Qian Chen, Yu-Ming Liu, Xudong |
| description | Purpose
This study was to evaluate the associations of dietary intake of total and specific phytosterols and risk of esophageal squamous cell carcinoma (ESCC) and to explore their joint effects with PLCE1 rs2274223 polymorphisms.
Methods
A population-based case–control study was conducted in a Chinese rural population and 856 eligible incident ESCC cases and 856 controls were included. A validated food frequency questionnaire was used to collect dietary consumption and PLCE1 rs2274223 polymorphisms were genotyped. Unadjusted and adjusted odds ratios (ORs) with 95% confidence interval (CI) were assessed via logistic regression model.
Results
When comparing the highest with lowest intake quartiles, β-sitosterol, campesterol, stigmasterol, β-sitostanol, campestanol, and total phytosterols were all associated with a decreased risk of ESCC, with adjusted ORs being 0.32 (95% CI 0.20–0.48), 0.18 (95% CI 0.11–0.27), 0.45 (95% CI 0.29–0.70), 0.13 (95% CI 0.08–0.20), 0.14 (95% CI 0.09–0.22) and 0.28 (95% CI 0.18–0.43), respectively. An exposure—response relationship was also observed for both total and five specific phytosterols (all
P
for trend |
| doi_str_mv | 10.1007/s00394-021-02561-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2534613712</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2593954870</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-18407b529dd947b94cb9a12e49e9ce661e07d4668f4224dc2c18fdd58aeb6f23</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhSMEoqXwAiyQJTZsAv6LHS_RqNBKI8Gi-8ixb2bcJnbqmyzmMfrGeDptkViw8I_k75x75FNVHxn9yijV35BSYWRNOSurUaw2r6pzJoWqFWfN65c71WfVO8RbSikXir2tzoSkUmnKzquH6-hhhrLFhdjoSZrnhCHuiEVMLtglpIgkDcQHWGw-kHl_WBIukNOIJMTF3sGj8Pd2c8lIRs615FyQOY2HKeV5H3AqBpEApnlvd2BHgverndKKxME4EmezCzFNluSAd--rN4MdET48nRfVzY_Lm81Vvf3183rzfVs7oZulZq2kum-48d5I3RvpemMZB2nAOFCKAdVeKtUOJY30jjvWDt43rYVeDVxcVF9OtnNO9yvg0k0Bj3FshJKs442QignNjujnf9DbtOZYwhXKCNPIVtNC8RPlckLMMHRzDlP5sY7R7thXd-qrK311j311pog-PVmv_QT-RfJcUAHECcDyFHeQ_87-j-0fFXeh5Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2593954870</pqid></control><display><type>article</type><title>Independent and opposing associations of dietary phytosterols intake and PLCE1 rs2274223 polymorphisms on esophageal squamous cell carcinoma risk</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Wang, Shuyi ; Zhao, Wenjing ; Sun, Liping ; Xiao, Su-Mei ; Lin, Sihao ; Zhao, Jin ; Xiao, Hengyi ; Xing, Xiangbin ; Lao, Xiang Qian ; Chen, Yu-Ming ; Liu, Xudong</creator><creatorcontrib>Wang, Shuyi ; Zhao, Wenjing ; Sun, Liping ; Xiao, Su-Mei ; Lin, Sihao ; Zhao, Jin ; Xiao, Hengyi ; Xing, Xiangbin ; Lao, Xiang Qian ; Chen, Yu-Ming ; Liu, Xudong</creatorcontrib><description>Purpose
This study was to evaluate the associations of dietary intake of total and specific phytosterols and risk of esophageal squamous cell carcinoma (ESCC) and to explore their joint effects with PLCE1 rs2274223 polymorphisms.
Methods
A population-based case–control study was conducted in a Chinese rural population and 856 eligible incident ESCC cases and 856 controls were included. A validated food frequency questionnaire was used to collect dietary consumption and PLCE1 rs2274223 polymorphisms were genotyped. Unadjusted and adjusted odds ratios (ORs) with 95% confidence interval (CI) were assessed via logistic regression model.
Results
When comparing the highest with lowest intake quartiles, β-sitosterol, campesterol, stigmasterol, β-sitostanol, campestanol, and total phytosterols were all associated with a decreased risk of ESCC, with adjusted ORs being 0.32 (95% CI 0.20–0.48), 0.18 (95% CI 0.11–0.27), 0.45 (95% CI 0.29–0.70), 0.13 (95% CI 0.08–0.20), 0.14 (95% CI 0.09–0.22) and 0.28 (95% CI 0.18–0.43), respectively. An exposure—response relationship was also observed for both total and five specific phytosterols (all
P
for trend < 0.001). In comparison to rs2274223 AA genotype, both GA genotype (OR: 1.47, 95% CI 1.16–1.85) and GG genotype (OR: 2.13, 95% CI 1.20–3.84) were associated with an increased risk of ESCC. However, no interaction was observed between total/specific phytosterols intake and rs2274223 polymorphisms.
Conclusion
Higher dietary intake of total and five specific phytosterols was associated with a lower risk of ESCC, and the risk of ESCC increased with the increment of rs2274223 G allele. The negative association between phytosterols and ESCC risk was not modified by rs2274223 polymorphisms. Foods or supplements rich in phytosterols are a promising source for chemoprevention of ESCC, and still, clinical trials will be required in any specific case.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-021-02561-9</identifier><identifier>PMID: 34046701</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Case-Control Studies ; Chemistry ; Chemistry and Materials Science ; Clinical trials ; Diet ; Dietary intake ; Eating ; Esophageal cancer ; Esophageal Neoplasms - epidemiology ; Esophageal Neoplasms - genetics ; Esophageal Squamous Cell Carcinoma - genetics ; Esophagus ; Genetic Predisposition to Disease ; Genotype & phenotype ; Humans ; Nutrition ; Original Contribution ; Phosphoinositide Phospholipase C - genetics ; Phytosterols ; Polymorphism, Single Nucleotide ; Population studies ; Squamous cell carcinoma</subject><ispartof>European journal of nutrition, 2021-12, Vol.60 (8), p.4357-4366</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-18407b529dd947b94cb9a12e49e9ce661e07d4668f4224dc2c18fdd58aeb6f23</citedby><cites>FETCH-LOGICAL-c375t-18407b529dd947b94cb9a12e49e9ce661e07d4668f4224dc2c18fdd58aeb6f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-021-02561-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-021-02561-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34046701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shuyi</creatorcontrib><creatorcontrib>Zhao, Wenjing</creatorcontrib><creatorcontrib>Sun, Liping</creatorcontrib><creatorcontrib>Xiao, Su-Mei</creatorcontrib><creatorcontrib>Lin, Sihao</creatorcontrib><creatorcontrib>Zhao, Jin</creatorcontrib><creatorcontrib>Xiao, Hengyi</creatorcontrib><creatorcontrib>Xing, Xiangbin</creatorcontrib><creatorcontrib>Lao, Xiang Qian</creatorcontrib><creatorcontrib>Chen, Yu-Ming</creatorcontrib><creatorcontrib>Liu, Xudong</creatorcontrib><title>Independent and opposing associations of dietary phytosterols intake and PLCE1 rs2274223 polymorphisms on esophageal squamous cell carcinoma risk</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
This study was to evaluate the associations of dietary intake of total and specific phytosterols and risk of esophageal squamous cell carcinoma (ESCC) and to explore their joint effects with PLCE1 rs2274223 polymorphisms.
Methods
A population-based case–control study was conducted in a Chinese rural population and 856 eligible incident ESCC cases and 856 controls were included. A validated food frequency questionnaire was used to collect dietary consumption and PLCE1 rs2274223 polymorphisms were genotyped. Unadjusted and adjusted odds ratios (ORs) with 95% confidence interval (CI) were assessed via logistic regression model.
Results
When comparing the highest with lowest intake quartiles, β-sitosterol, campesterol, stigmasterol, β-sitostanol, campestanol, and total phytosterols were all associated with a decreased risk of ESCC, with adjusted ORs being 0.32 (95% CI 0.20–0.48), 0.18 (95% CI 0.11–0.27), 0.45 (95% CI 0.29–0.70), 0.13 (95% CI 0.08–0.20), 0.14 (95% CI 0.09–0.22) and 0.28 (95% CI 0.18–0.43), respectively. An exposure—response relationship was also observed for both total and five specific phytosterols (all
P
for trend < 0.001). In comparison to rs2274223 AA genotype, both GA genotype (OR: 1.47, 95% CI 1.16–1.85) and GG genotype (OR: 2.13, 95% CI 1.20–3.84) were associated with an increased risk of ESCC. However, no interaction was observed between total/specific phytosterols intake and rs2274223 polymorphisms.
Conclusion
Higher dietary intake of total and five specific phytosterols was associated with a lower risk of ESCC, and the risk of ESCC increased with the increment of rs2274223 G allele. The negative association between phytosterols and ESCC risk was not modified by rs2274223 polymorphisms. Foods or supplements rich in phytosterols are a promising source for chemoprevention of ESCC, and still, clinical trials will be required in any specific case.</description><subject>Case-Control Studies</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Clinical trials</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Eating</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Squamous Cell Carcinoma - genetics</subject><subject>Esophagus</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Phosphoinositide Phospholipase C - genetics</subject><subject>Phytosterols</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population studies</subject><subject>Squamous cell carcinoma</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kc1u1DAUhSMEoqXwAiyQJTZsAv6LHS_RqNBKI8Gi-8ixb2bcJnbqmyzmMfrGeDptkViw8I_k75x75FNVHxn9yijV35BSYWRNOSurUaw2r6pzJoWqFWfN65c71WfVO8RbSikXir2tzoSkUmnKzquH6-hhhrLFhdjoSZrnhCHuiEVMLtglpIgkDcQHWGw-kHl_WBIukNOIJMTF3sGj8Pd2c8lIRs615FyQOY2HKeV5H3AqBpEApnlvd2BHgverndKKxME4EmezCzFNluSAd--rN4MdET48nRfVzY_Lm81Vvf3183rzfVs7oZulZq2kum-48d5I3RvpemMZB2nAOFCKAdVeKtUOJY30jjvWDt43rYVeDVxcVF9OtnNO9yvg0k0Bj3FshJKs442QignNjujnf9DbtOZYwhXKCNPIVtNC8RPlckLMMHRzDlP5sY7R7thXd-qrK311j311pog-PVmv_QT-RfJcUAHECcDyFHeQ_87-j-0fFXeh5Q</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Wang, Shuyi</creator><creator>Zhao, Wenjing</creator><creator>Sun, Liping</creator><creator>Xiao, Su-Mei</creator><creator>Lin, Sihao</creator><creator>Zhao, Jin</creator><creator>Xiao, Hengyi</creator><creator>Xing, Xiangbin</creator><creator>Lao, Xiang Qian</creator><creator>Chen, Yu-Ming</creator><creator>Liu, Xudong</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>Independent and opposing associations of dietary phytosterols intake and PLCE1 rs2274223 polymorphisms on esophageal squamous cell carcinoma risk</title><author>Wang, Shuyi ; Zhao, Wenjing ; Sun, Liping ; Xiao, Su-Mei ; Lin, Sihao ; Zhao, Jin ; Xiao, Hengyi ; Xing, Xiangbin ; Lao, Xiang Qian ; Chen, Yu-Ming ; Liu, Xudong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-18407b529dd947b94cb9a12e49e9ce661e07d4668f4224dc2c18fdd58aeb6f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Case-Control Studies</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Clinical trials</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Eating</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - epidemiology</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Squamous Cell Carcinoma - genetics</topic><topic>Esophagus</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Phosphoinositide Phospholipase C - genetics</topic><topic>Phytosterols</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population studies</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shuyi</creatorcontrib><creatorcontrib>Zhao, Wenjing</creatorcontrib><creatorcontrib>Sun, Liping</creatorcontrib><creatorcontrib>Xiao, Su-Mei</creatorcontrib><creatorcontrib>Lin, Sihao</creatorcontrib><creatorcontrib>Zhao, Jin</creatorcontrib><creatorcontrib>Xiao, Hengyi</creatorcontrib><creatorcontrib>Xing, Xiangbin</creatorcontrib><creatorcontrib>Lao, Xiang Qian</creatorcontrib><creatorcontrib>Chen, Yu-Ming</creatorcontrib><creatorcontrib>Liu, Xudong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shuyi</au><au>Zhao, Wenjing</au><au>Sun, Liping</au><au>Xiao, Su-Mei</au><au>Lin, Sihao</au><au>Zhao, Jin</au><au>Xiao, Hengyi</au><au>Xing, Xiangbin</au><au>Lao, Xiang Qian</au><au>Chen, Yu-Ming</au><au>Liu, Xudong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Independent and opposing associations of dietary phytosterols intake and PLCE1 rs2274223 polymorphisms on esophageal squamous cell carcinoma risk</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>60</volume><issue>8</issue><spage>4357</spage><epage>4366</epage><pages>4357-4366</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
This study was to evaluate the associations of dietary intake of total and specific phytosterols and risk of esophageal squamous cell carcinoma (ESCC) and to explore their joint effects with PLCE1 rs2274223 polymorphisms.
Methods
A population-based case–control study was conducted in a Chinese rural population and 856 eligible incident ESCC cases and 856 controls were included. A validated food frequency questionnaire was used to collect dietary consumption and PLCE1 rs2274223 polymorphisms were genotyped. Unadjusted and adjusted odds ratios (ORs) with 95% confidence interval (CI) were assessed via logistic regression model.
Results
When comparing the highest with lowest intake quartiles, β-sitosterol, campesterol, stigmasterol, β-sitostanol, campestanol, and total phytosterols were all associated with a decreased risk of ESCC, with adjusted ORs being 0.32 (95% CI 0.20–0.48), 0.18 (95% CI 0.11–0.27), 0.45 (95% CI 0.29–0.70), 0.13 (95% CI 0.08–0.20), 0.14 (95% CI 0.09–0.22) and 0.28 (95% CI 0.18–0.43), respectively. An exposure—response relationship was also observed for both total and five specific phytosterols (all
P
for trend < 0.001). In comparison to rs2274223 AA genotype, both GA genotype (OR: 1.47, 95% CI 1.16–1.85) and GG genotype (OR: 2.13, 95% CI 1.20–3.84) were associated with an increased risk of ESCC. However, no interaction was observed between total/specific phytosterols intake and rs2274223 polymorphisms.
Conclusion
Higher dietary intake of total and five specific phytosterols was associated with a lower risk of ESCC, and the risk of ESCC increased with the increment of rs2274223 G allele. The negative association between phytosterols and ESCC risk was not modified by rs2274223 polymorphisms. Foods or supplements rich in phytosterols are a promising source for chemoprevention of ESCC, and still, clinical trials will be required in any specific case.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34046701</pmid><doi>10.1007/s00394-021-02561-9</doi><tpages>10</tpages></addata></record> |
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| subjects | Case-Control Studies Chemistry Chemistry and Materials Science Clinical trials Diet Dietary intake Eating Esophageal cancer Esophageal Neoplasms - epidemiology Esophageal Neoplasms - genetics Esophageal Squamous Cell Carcinoma - genetics Esophagus Genetic Predisposition to Disease Genotype & phenotype Humans Nutrition Original Contribution Phosphoinositide Phospholipase C - genetics Phytosterols Polymorphism, Single Nucleotide Population studies Squamous cell carcinoma |
| title | Independent and opposing associations of dietary phytosterols intake and PLCE1 rs2274223 polymorphisms on esophageal squamous cell carcinoma risk |
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