Microstructural Abnormalities of the Dentatorubrothalamic Tract in Cervical Dystonia
Background The dentatorubrothalamic tract (DRTT) remains understudied in idiopathic cervical dystonia (CD), despite evidence that the pathway is relevant in the pathophysiology of the disorder. Objective The aim of this study was to examine the DRTT in patients with CD using diffusion tensor imaging...
Gespeichert in:
| Veröffentlicht in: | Movement disorders 2021-09, Vol.36 (9), p.2192-2198 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2198 |
|---|---|
| container_issue | 9 |
| container_start_page | 2192 |
| container_title | Movement disorders |
| container_volume | 36 |
| creator | Sondergaard, Rachel E. Rockel, Conrad P. Cortese, Filomeno Jasaui, Yamile Pringsheim, Tamara M. Sarna, Justyna R. Monchi, Oury Sadikot, Abbas F. Pike, Bruce G. Martino, Davide |
| description | Background
The dentatorubrothalamic tract (DRTT) remains understudied in idiopathic cervical dystonia (CD), despite evidence that the pathway is relevant in the pathophysiology of the disorder.
Objective
The aim of this study was to examine the DRTT in patients with CD using diffusion tensor imaging (DTI)–based tractography.
Methods
Magnetic resonance imaging scans from 67 participants were collected to calculate diffusion tractography metrics using a binary tractography‐based DRTT template. Fractional anisotropy and diffusivity measures of left and right DRTT were computed and compared between 32 subjects with CD and 35 age‐matched healthy volunteers.
Results
Fractional anisotropy of right DRTT and mean and axial diffusivity of left DRTT were significantly reduced in patients with CD. Similar abnormalities were observed in patients with focal CD and patients with CD without tremor. DTI metrics did not correlate with disease duration or severity.
Conclusions
Significant reductions in DTI measures suggest microstructural abnormalities within the DRTT in CD, characterized by a tractography pattern consistent with decreased axonal integrity. © 2021 International Parkinson and Movement Disorder Society |
| doi_str_mv | 10.1002/mds.28649 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2534612393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2574421706</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3309-61899b83edd5fda515c315f7900efcc4670d0641069f1b0754d09e918ee745793</originalsourceid><addsrcrecordid>eNp10D1PwzAQgGELgUQpDPyDSCwwhPri2LHHquVLasVAmS3HcVRXSVxsB9R_T0qYkJhuee50ehG6BnwPGGeztgr3GWe5OEEToARSntHiFE0w5zQlwOk5ughhhzEABTZBm7XV3oXoex17r5pkXnbOt6qx0ZqQuDqJW5MsTRdVdL4vvYtb1ajW6mTjlY6J7ZKF8Z9WD7vLQ4ius-oSndWqCebqd07R--PDZvGcrl6fXhbzVaoJwSJlwIUoOTFVRetKUaCaAK0LgbGptc5ZgSvMcsBM1FDiguYVFkYAN6bIaSHIFN2Od_feffQmRNnaoE3TqM64PsiMkpxBRgQZ6M0funO974bvBlXkeQYFZoO6G9WxSfCmlntvW-UPErA89pVDX_nTd7Cz0X7Zxhz-h3K9fBs3vgHrrnvY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2574421706</pqid></control><display><type>article</type><title>Microstructural Abnormalities of the Dentatorubrothalamic Tract in Cervical Dystonia</title><source>Access via Wiley Online Library</source><creator>Sondergaard, Rachel E. ; Rockel, Conrad P. ; Cortese, Filomeno ; Jasaui, Yamile ; Pringsheim, Tamara M. ; Sarna, Justyna R. ; Monchi, Oury ; Sadikot, Abbas F. ; Pike, Bruce G. ; Martino, Davide</creator><creatorcontrib>Sondergaard, Rachel E. ; Rockel, Conrad P. ; Cortese, Filomeno ; Jasaui, Yamile ; Pringsheim, Tamara M. ; Sarna, Justyna R. ; Monchi, Oury ; Sadikot, Abbas F. ; Pike, Bruce G. ; Martino, Davide</creatorcontrib><description>Background
The dentatorubrothalamic tract (DRTT) remains understudied in idiopathic cervical dystonia (CD), despite evidence that the pathway is relevant in the pathophysiology of the disorder.
Objective
The aim of this study was to examine the DRTT in patients with CD using diffusion tensor imaging (DTI)–based tractography.
Methods
Magnetic resonance imaging scans from 67 participants were collected to calculate diffusion tractography metrics using a binary tractography‐based DRTT template. Fractional anisotropy and diffusivity measures of left and right DRTT were computed and compared between 32 subjects with CD and 35 age‐matched healthy volunteers.
Results
Fractional anisotropy of right DRTT and mean and axial diffusivity of left DRTT were significantly reduced in patients with CD. Similar abnormalities were observed in patients with focal CD and patients with CD without tremor. DTI metrics did not correlate with disease duration or severity.
Conclusions
Significant reductions in DTI measures suggest microstructural abnormalities within the DRTT in CD, characterized by a tractography pattern consistent with decreased axonal integrity. © 2021 International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.28649</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Anisotropy ; cervical dystonia ; dentatorubrothalamic tract ; diffusion tractography ; Dystonia ; Magnetic resonance imaging ; Movement disorders ; Tremor</subject><ispartof>Movement disorders, 2021-09, Vol.36 (9), p.2192-2198</ispartof><rights>2021 International Parkinson and Movement Disorder Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3309-61899b83edd5fda515c315f7900efcc4670d0641069f1b0754d09e918ee745793</citedby><cites>FETCH-LOGICAL-c3309-61899b83edd5fda515c315f7900efcc4670d0641069f1b0754d09e918ee745793</cites><orcidid>0000-0002-2217-0487 ; 0000-0003-1556-7221</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.28649$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.28649$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Sondergaard, Rachel E.</creatorcontrib><creatorcontrib>Rockel, Conrad P.</creatorcontrib><creatorcontrib>Cortese, Filomeno</creatorcontrib><creatorcontrib>Jasaui, Yamile</creatorcontrib><creatorcontrib>Pringsheim, Tamara M.</creatorcontrib><creatorcontrib>Sarna, Justyna R.</creatorcontrib><creatorcontrib>Monchi, Oury</creatorcontrib><creatorcontrib>Sadikot, Abbas F.</creatorcontrib><creatorcontrib>Pike, Bruce G.</creatorcontrib><creatorcontrib>Martino, Davide</creatorcontrib><title>Microstructural Abnormalities of the Dentatorubrothalamic Tract in Cervical Dystonia</title><title>Movement disorders</title><description>Background
The dentatorubrothalamic tract (DRTT) remains understudied in idiopathic cervical dystonia (CD), despite evidence that the pathway is relevant in the pathophysiology of the disorder.
Objective
The aim of this study was to examine the DRTT in patients with CD using diffusion tensor imaging (DTI)–based tractography.
Methods
Magnetic resonance imaging scans from 67 participants were collected to calculate diffusion tractography metrics using a binary tractography‐based DRTT template. Fractional anisotropy and diffusivity measures of left and right DRTT were computed and compared between 32 subjects with CD and 35 age‐matched healthy volunteers.
Results
Fractional anisotropy of right DRTT and mean and axial diffusivity of left DRTT were significantly reduced in patients with CD. Similar abnormalities were observed in patients with focal CD and patients with CD without tremor. DTI metrics did not correlate with disease duration or severity.
Conclusions
Significant reductions in DTI measures suggest microstructural abnormalities within the DRTT in CD, characterized by a tractography pattern consistent with decreased axonal integrity. © 2021 International Parkinson and Movement Disorder Society</description><subject>Anisotropy</subject><subject>cervical dystonia</subject><subject>dentatorubrothalamic tract</subject><subject>diffusion tractography</subject><subject>Dystonia</subject><subject>Magnetic resonance imaging</subject><subject>Movement disorders</subject><subject>Tremor</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10D1PwzAQgGELgUQpDPyDSCwwhPri2LHHquVLasVAmS3HcVRXSVxsB9R_T0qYkJhuee50ehG6BnwPGGeztgr3GWe5OEEToARSntHiFE0w5zQlwOk5ughhhzEABTZBm7XV3oXoex17r5pkXnbOt6qx0ZqQuDqJW5MsTRdVdL4vvYtb1ajW6mTjlY6J7ZKF8Z9WD7vLQ4ius-oSndWqCebqd07R--PDZvGcrl6fXhbzVaoJwSJlwIUoOTFVRetKUaCaAK0LgbGptc5ZgSvMcsBM1FDiguYVFkYAN6bIaSHIFN2Od_feffQmRNnaoE3TqM64PsiMkpxBRgQZ6M0funO974bvBlXkeQYFZoO6G9WxSfCmlntvW-UPErA89pVDX_nTd7Cz0X7Zxhz-h3K9fBs3vgHrrnvY</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Sondergaard, Rachel E.</creator><creator>Rockel, Conrad P.</creator><creator>Cortese, Filomeno</creator><creator>Jasaui, Yamile</creator><creator>Pringsheim, Tamara M.</creator><creator>Sarna, Justyna R.</creator><creator>Monchi, Oury</creator><creator>Sadikot, Abbas F.</creator><creator>Pike, Bruce G.</creator><creator>Martino, Davide</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2217-0487</orcidid><orcidid>https://orcid.org/0000-0003-1556-7221</orcidid></search><sort><creationdate>202109</creationdate><title>Microstructural Abnormalities of the Dentatorubrothalamic Tract in Cervical Dystonia</title><author>Sondergaard, Rachel E. ; Rockel, Conrad P. ; Cortese, Filomeno ; Jasaui, Yamile ; Pringsheim, Tamara M. ; Sarna, Justyna R. ; Monchi, Oury ; Sadikot, Abbas F. ; Pike, Bruce G. ; Martino, Davide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3309-61899b83edd5fda515c315f7900efcc4670d0641069f1b0754d09e918ee745793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anisotropy</topic><topic>cervical dystonia</topic><topic>dentatorubrothalamic tract</topic><topic>diffusion tractography</topic><topic>Dystonia</topic><topic>Magnetic resonance imaging</topic><topic>Movement disorders</topic><topic>Tremor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sondergaard, Rachel E.</creatorcontrib><creatorcontrib>Rockel, Conrad P.</creatorcontrib><creatorcontrib>Cortese, Filomeno</creatorcontrib><creatorcontrib>Jasaui, Yamile</creatorcontrib><creatorcontrib>Pringsheim, Tamara M.</creatorcontrib><creatorcontrib>Sarna, Justyna R.</creatorcontrib><creatorcontrib>Monchi, Oury</creatorcontrib><creatorcontrib>Sadikot, Abbas F.</creatorcontrib><creatorcontrib>Pike, Bruce G.</creatorcontrib><creatorcontrib>Martino, Davide</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sondergaard, Rachel E.</au><au>Rockel, Conrad P.</au><au>Cortese, Filomeno</au><au>Jasaui, Yamile</au><au>Pringsheim, Tamara M.</au><au>Sarna, Justyna R.</au><au>Monchi, Oury</au><au>Sadikot, Abbas F.</au><au>Pike, Bruce G.</au><au>Martino, Davide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microstructural Abnormalities of the Dentatorubrothalamic Tract in Cervical Dystonia</atitle><jtitle>Movement disorders</jtitle><date>2021-09</date><risdate>2021</risdate><volume>36</volume><issue>9</issue><spage>2192</spage><epage>2198</epage><pages>2192-2198</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>Background
The dentatorubrothalamic tract (DRTT) remains understudied in idiopathic cervical dystonia (CD), despite evidence that the pathway is relevant in the pathophysiology of the disorder.
Objective
The aim of this study was to examine the DRTT in patients with CD using diffusion tensor imaging (DTI)–based tractography.
Methods
Magnetic resonance imaging scans from 67 participants were collected to calculate diffusion tractography metrics using a binary tractography‐based DRTT template. Fractional anisotropy and diffusivity measures of left and right DRTT were computed and compared between 32 subjects with CD and 35 age‐matched healthy volunteers.
Results
Fractional anisotropy of right DRTT and mean and axial diffusivity of left DRTT were significantly reduced in patients with CD. Similar abnormalities were observed in patients with focal CD and patients with CD without tremor. DTI metrics did not correlate with disease duration or severity.
Conclusions
Significant reductions in DTI measures suggest microstructural abnormalities within the DRTT in CD, characterized by a tractography pattern consistent with decreased axonal integrity. © 2021 International Parkinson and Movement Disorder Society</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/mds.28649</doi><tpages>26</tpages><orcidid>https://orcid.org/0000-0002-2217-0487</orcidid><orcidid>https://orcid.org/0000-0003-1556-7221</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-3185 |
| ispartof | Movement disorders, 2021-09, Vol.36 (9), p.2192-2198 |
| issn | 0885-3185 1531-8257 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2534612393 |
| source | Access via Wiley Online Library |
| subjects | Anisotropy cervical dystonia dentatorubrothalamic tract diffusion tractography Dystonia Magnetic resonance imaging Movement disorders Tremor |
| title | Microstructural Abnormalities of the Dentatorubrothalamic Tract in Cervical Dystonia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T19%3A02%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microstructural%20Abnormalities%20of%20the%20Dentatorubrothalamic%20Tract%20in%20Cervical%20Dystonia&rft.jtitle=Movement%20disorders&rft.au=Sondergaard,%20Rachel%20E.&rft.date=2021-09&rft.volume=36&rft.issue=9&rft.spage=2192&rft.epage=2198&rft.pages=2192-2198&rft.issn=0885-3185&rft.eissn=1531-8257&rft_id=info:doi/10.1002/mds.28649&rft_dat=%3Cproquest_cross%3E2574421706%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2574421706&rft_id=info:pmid/&rfr_iscdi=true |