TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer

Karyopherin-β proteins are critically involved in cancer progression and have been reported as potential biomarkers and therapeutic targets for tumor treatment. However, TNPO1, as an important karyopherin-β family member, underlying functional roles in cancers remain largely unclear. In this study,...

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Veröffentlicht in:	Cancer letters 2021-09, Vol.515, p.14-27
Hauptverfasser:	Yang, Bikang, Chen, Jing, Li, Xiao, Zhang, Xueli, Hu, Lipeng, Jiang, Shuheng, Zhang, Zhigang, Teng, Yincheng
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activator protein 1 AKT protein Animals ARID1A-deficient gynecologic cancer ARID1B beta Karyopherins - genetics Cancer Cell culture Cell Line, Tumor Cell Proliferation - genetics Cervical cancer Cervix Chromatin Class I Phosphatidylinositol 3-Kinases - genetics DNA-Binding Proteins - genetics Endometrial cancer Female Fibroblast growth factor receptor 2 Gene expression Gene Expression Regulation, Neoplastic - genetics Genital Neoplasms, Female - genetics Genital Neoplasms, Female - pathology HeLa Cells Humans Localization Mice Mice, Inbred BALB C Mice, Nude Microscopy Mutation - genetics Nuclear transport Ovarian cancer Proteins Signal transduction TNPO1 Transcription factors Transcription Factors - genetics Tumorigenesis Tumors Vulnerability
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