Evaluating the radioprotective effect of single dose and daily oral consumption of green tea, grape seed, and coffee bean extracts against gamma irradiation
The aim of this study was to investigate and compare the radio-protective effect of green tea, grape seed, and coffee bean extracts in different oral consumption methods in mice. In this experimental-quantitative study 150 mice in 15 equally sized groups were used. For each extract, two groups recei...
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| Veröffentlicht in: | Applied radiation and isotopes 2021-08, Vol.174, p.109781-109781, Article 109781 |
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| container_title | Applied radiation and isotopes |
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| creator | Ansari, Leyla Banaei, Amin Dastranj, Leila Majdaeen, Mehrsa Vafapour, Hassan Zamani, Hamed Ataei, Gholamreza Abedi-Firouzjah, Razzagh |
| description | The aim of this study was to investigate and compare the radio-protective effect of green tea, grape seed, and coffee bean extracts in different oral consumption methods in mice.
In this experimental-quantitative study 150 mice in 15 equally sized groups were used. For each extract, two groups received 200 mg/kg of herbal extracts’ combination for 7 and 30 consecutive days before irradiation, and one group received 800 mg/kg of the extract 2 h before irradiation (3 Gy gamma-rays of Co-60). The similar groups were classified to receive a combination of the plant extracts (green tea, grape seed, and coffee bean). Irradiation without consuming plant extract (irradiated group), and a control group were also devised. Alkaline comet and micronucleus assays were used to investigate the radioprotective effect on mice blood and bone marrow cells, respectively.
Consumption of all plant extracts significantly decreased the radiation damage to blood and bone marrow cells, compared to the irradiated group (p |
| doi_str_mv | 10.1016/j.apradiso.2021.109781 |
| format | Article |
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In this experimental-quantitative study 150 mice in 15 equally sized groups were used. For each extract, two groups received 200 mg/kg of herbal extracts’ combination for 7 and 30 consecutive days before irradiation, and one group received 800 mg/kg of the extract 2 h before irradiation (3 Gy gamma-rays of Co-60). The similar groups were classified to receive a combination of the plant extracts (green tea, grape seed, and coffee bean). Irradiation without consuming plant extract (irradiated group), and a control group were also devised. Alkaline comet and micronucleus assays were used to investigate the radioprotective effect on mice blood and bone marrow cells, respectively.
Consumption of all plant extracts significantly decreased the radiation damage to blood and bone marrow cells, compared to the irradiated group (p < 0.01), with grape seed extract showing higher protective effect. Continuous daily oral consumption (one week/month) showed a significant higher radioprotective effect compared to single consumption (p < 0.05). Continuous consumption of the combination of the extracts showed a higher radio-protection in comparison to each of the plant extracts (p < 0.03).
The radioprotective effect of continuous consumption (for one week/month) of the plant extracts was greater than single dose. In continuous consumption protocols, we found the synergetic property and higher radioprotective effect of the plant extract combination compared to each one.
•Investigating the radio-protective effect of green tea, grape seed, and coffee bean extracts in oral consumption methods.•Alkaline comet and micronucleus assays were used.•Consumption of all plant extracts significantly decreased the radiation damage to blood and bone marrow cells.•Continuous daily oral consumption showed a significant higher radioprotective effect compared to single consumption.</description><identifier>ISSN: 0969-8043</identifier><identifier>EISSN: 1872-9800</identifier><identifier>DOI: 10.1016/j.apradiso.2021.109781</identifier><identifier>PMID: 34048991</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Oral ; Animals ; Coffee - chemistry ; Coffee bean extract ; Comet Assay ; Gamma Rays ; Grape seed ; Green tea ; Male ; Mice ; Mice, Inbred BALB C ; Micronucleus assessment ; Plant Extracts - administration & dosage ; Plant Extracts - therapeutic use ; Radiation Injuries - prevention & control ; Radiation protection ; Radiation-Protective Agents - administration & dosage ; Radiation-Protective Agents - therapeutic use ; Seeds - chemistry ; Tea - chemistry ; Vitis - embryology</subject><ispartof>Applied radiation and isotopes, 2021-08, Vol.174, p.109781-109781, Article 109781</ispartof><rights>2021 Elsevier Ltd</rights><rights>Copyright © 2021 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-a1fea8e1dab2b41b22344d3db8b7f8d5ab2be868759dbed270d08031470ab5023</citedby><cites>FETCH-LOGICAL-c368t-a1fea8e1dab2b41b22344d3db8b7f8d5ab2be868759dbed270d08031470ab5023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.apradiso.2021.109781$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34048991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ansari, Leyla</creatorcontrib><creatorcontrib>Banaei, Amin</creatorcontrib><creatorcontrib>Dastranj, Leila</creatorcontrib><creatorcontrib>Majdaeen, Mehrsa</creatorcontrib><creatorcontrib>Vafapour, Hassan</creatorcontrib><creatorcontrib>Zamani, Hamed</creatorcontrib><creatorcontrib>Ataei, Gholamreza</creatorcontrib><creatorcontrib>Abedi-Firouzjah, Razzagh</creatorcontrib><title>Evaluating the radioprotective effect of single dose and daily oral consumption of green tea, grape seed, and coffee bean extracts against gamma irradiation</title><title>Applied radiation and isotopes</title><addtitle>Appl Radiat Isot</addtitle><description>The aim of this study was to investigate and compare the radio-protective effect of green tea, grape seed, and coffee bean extracts in different oral consumption methods in mice.
In this experimental-quantitative study 150 mice in 15 equally sized groups were used. For each extract, two groups received 200 mg/kg of herbal extracts’ combination for 7 and 30 consecutive days before irradiation, and one group received 800 mg/kg of the extract 2 h before irradiation (3 Gy gamma-rays of Co-60). The similar groups were classified to receive a combination of the plant extracts (green tea, grape seed, and coffee bean). Irradiation without consuming plant extract (irradiated group), and a control group were also devised. Alkaline comet and micronucleus assays were used to investigate the radioprotective effect on mice blood and bone marrow cells, respectively.
Consumption of all plant extracts significantly decreased the radiation damage to blood and bone marrow cells, compared to the irradiated group (p < 0.01), with grape seed extract showing higher protective effect. Continuous daily oral consumption (one week/month) showed a significant higher radioprotective effect compared to single consumption (p < 0.05). Continuous consumption of the combination of the extracts showed a higher radio-protection in comparison to each of the plant extracts (p < 0.03).
The radioprotective effect of continuous consumption (for one week/month) of the plant extracts was greater than single dose. In continuous consumption protocols, we found the synergetic property and higher radioprotective effect of the plant extract combination compared to each one.
•Investigating the radio-protective effect of green tea, grape seed, and coffee bean extracts in oral consumption methods.•Alkaline comet and micronucleus assays were used.•Consumption of all plant extracts significantly decreased the radiation damage to blood and bone marrow cells.•Continuous daily oral consumption showed a significant higher radioprotective effect compared to single consumption.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Coffee - chemistry</subject><subject>Coffee bean extract</subject><subject>Comet Assay</subject><subject>Gamma Rays</subject><subject>Grape seed</subject><subject>Green tea</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Micronucleus assessment</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - therapeutic use</subject><subject>Radiation Injuries - prevention & control</subject><subject>Radiation protection</subject><subject>Radiation-Protective Agents - administration & dosage</subject><subject>Radiation-Protective Agents - therapeutic use</subject><subject>Seeds - chemistry</subject><subject>Tea - chemistry</subject><subject>Vitis - embryology</subject><issn>0969-8043</issn><issn>1872-9800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUha0K1E4Lr1B5yaIZ_JNJnB2o6g9SJTawtq7jm8GjxA62M6LvwsPiMC1bVj66OudcX32EXHO25Yw3Hw9bmCNYl8JWMMHLsGsVPyMbrlpRdYqxN2TDuqarFKvlBblM6cAYq1UnzsmFrFfV8Q35fXeEcYHs_J7mH0jXzjDHkLHP7ogUh6EoGgaaimVEakNCCt5SC258piHCSPvg0zLN2QW_OvcR0dOMcFMkzEgTor35G-pD6UNqEDzFXzlCnxOFPTifMt3DNAF1cf0DrGXvyNsBxoTvX94r8v3-7tvtY_X09eHL7eenqpeNyhXwAUEht2CEqbkRQta1ldYo0w7K7tYxqka1u84atKJllikmed0yMDsm5BX5cOoth_9cMGU9udTjOILHsCQtdrJuOJeCF2tzsvYxpBRx0HN0E8RnzZleyeiDfiWjVzL6RKYEr192LGZC-y_2iqIYPp0MWC49Oow69Q59j9bFgkDb4P634w8p4qYa</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Ansari, Leyla</creator><creator>Banaei, Amin</creator><creator>Dastranj, Leila</creator><creator>Majdaeen, Mehrsa</creator><creator>Vafapour, Hassan</creator><creator>Zamani, Hamed</creator><creator>Ataei, Gholamreza</creator><creator>Abedi-Firouzjah, Razzagh</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202108</creationdate><title>Evaluating the radioprotective effect of single dose and daily oral consumption of green tea, grape seed, and coffee bean extracts against gamma irradiation</title><author>Ansari, Leyla ; Banaei, Amin ; Dastranj, Leila ; Majdaeen, Mehrsa ; Vafapour, Hassan ; Zamani, Hamed ; Ataei, Gholamreza ; Abedi-Firouzjah, Razzagh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-a1fea8e1dab2b41b22344d3db8b7f8d5ab2be868759dbed270d08031470ab5023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Coffee - chemistry</topic><topic>Coffee bean extract</topic><topic>Comet Assay</topic><topic>Gamma Rays</topic><topic>Grape seed</topic><topic>Green tea</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Micronucleus assessment</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - therapeutic use</topic><topic>Radiation Injuries - prevention & control</topic><topic>Radiation protection</topic><topic>Radiation-Protective Agents - administration & dosage</topic><topic>Radiation-Protective Agents - therapeutic use</topic><topic>Seeds - chemistry</topic><topic>Tea - chemistry</topic><topic>Vitis - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ansari, Leyla</creatorcontrib><creatorcontrib>Banaei, Amin</creatorcontrib><creatorcontrib>Dastranj, Leila</creatorcontrib><creatorcontrib>Majdaeen, Mehrsa</creatorcontrib><creatorcontrib>Vafapour, Hassan</creatorcontrib><creatorcontrib>Zamani, Hamed</creatorcontrib><creatorcontrib>Ataei, Gholamreza</creatorcontrib><creatorcontrib>Abedi-Firouzjah, Razzagh</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ansari, Leyla</au><au>Banaei, Amin</au><au>Dastranj, Leila</au><au>Majdaeen, Mehrsa</au><au>Vafapour, Hassan</au><au>Zamani, Hamed</au><au>Ataei, Gholamreza</au><au>Abedi-Firouzjah, Razzagh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluating the radioprotective effect of single dose and daily oral consumption of green tea, grape seed, and coffee bean extracts against gamma irradiation</atitle><jtitle>Applied radiation and isotopes</jtitle><addtitle>Appl Radiat Isot</addtitle><date>2021-08</date><risdate>2021</risdate><volume>174</volume><spage>109781</spage><epage>109781</epage><pages>109781-109781</pages><artnum>109781</artnum><issn>0969-8043</issn><eissn>1872-9800</eissn><abstract>The aim of this study was to investigate and compare the radio-protective effect of green tea, grape seed, and coffee bean extracts in different oral consumption methods in mice.
In this experimental-quantitative study 150 mice in 15 equally sized groups were used. For each extract, two groups received 200 mg/kg of herbal extracts’ combination for 7 and 30 consecutive days before irradiation, and one group received 800 mg/kg of the extract 2 h before irradiation (3 Gy gamma-rays of Co-60). The similar groups were classified to receive a combination of the plant extracts (green tea, grape seed, and coffee bean). Irradiation without consuming plant extract (irradiated group), and a control group were also devised. Alkaline comet and micronucleus assays were used to investigate the radioprotective effect on mice blood and bone marrow cells, respectively.
Consumption of all plant extracts significantly decreased the radiation damage to blood and bone marrow cells, compared to the irradiated group (p < 0.01), with grape seed extract showing higher protective effect. Continuous daily oral consumption (one week/month) showed a significant higher radioprotective effect compared to single consumption (p < 0.05). Continuous consumption of the combination of the extracts showed a higher radio-protection in comparison to each of the plant extracts (p < 0.03).
The radioprotective effect of continuous consumption (for one week/month) of the plant extracts was greater than single dose. In continuous consumption protocols, we found the synergetic property and higher radioprotective effect of the plant extract combination compared to each one.
•Investigating the radio-protective effect of green tea, grape seed, and coffee bean extracts in oral consumption methods.•Alkaline comet and micronucleus assays were used.•Consumption of all plant extracts significantly decreased the radiation damage to blood and bone marrow cells.•Continuous daily oral consumption showed a significant higher radioprotective effect compared to single consumption.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34048991</pmid><doi>10.1016/j.apradiso.2021.109781</doi><tpages>1</tpages></addata></record> |
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| identifier | ISSN: 0969-8043 |
| ispartof | Applied radiation and isotopes, 2021-08, Vol.174, p.109781-109781, Article 109781 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Oral Animals Coffee - chemistry Coffee bean extract Comet Assay Gamma Rays Grape seed Green tea Male Mice Mice, Inbred BALB C Micronucleus assessment Plant Extracts - administration & dosage Plant Extracts - therapeutic use Radiation Injuries - prevention & control Radiation protection Radiation-Protective Agents - administration & dosage Radiation-Protective Agents - therapeutic use Seeds - chemistry Tea - chemistry Vitis - embryology |
| title | Evaluating the radioprotective effect of single dose and daily oral consumption of green tea, grape seed, and coffee bean extracts against gamma irradiation |
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