Azilsartan prevented AGE‐induced inflammatory response and degradation of aggrecan in human chondrocytes through inhibition of Sox4

Advanced glycation end products (AGEs)‐induced inflammation and degradation of aggrecan in human chondrocytes play an important role in the progression and development of osteoarthritis (OA). Azilsartan, an angiotensin II receptor antagonist, has been licensed for the treatment of high blood pressur...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2021-08, Vol.35 (8), p.e22827-n/a
Hauptverfasser:	Lei, Jie, He, Mengyin, Xu, Liangzhou, He, Chengjian, Li, Jie, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced glycation end products Advanced glycosylation end products Age Aggrecan Angiotensin Angiotensin II Azilsartan Biomedical materials Blood pressure Cell viability Chondrocytes Cytokines Degradation Evaluation Gene expression Glycosylation Hypertension Inflammation Inflammatory response Interleukins Kinases Metalloproteinase Osteoarthritis Phosphorylation Polymerase chain reaction Pressure effects Protein kinase Proteins Sox4 Thrombospondin Tumor necrosis factor Tumor necrosis factor-TNF
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