Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis

Increased vascular permeability and leakage are hallmarks of several pathologies and determine disease progression and severity by facilitating inflammatory/metastatic cell infiltration. Using tissue-specific genetic ablation in endothelial cells, we have investigated in vivo the role of Tumor progr...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-05, Vol.35 (8), p.109168-109168, Article 109168
Hauptverfasser:	Nanou, Aikaterini, Bourbouli, Mara, Vetrano, Stefania, Schaeper, Ute, Ley, Steven, Kollias, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Claudin-5 Claudin-5 - metabolism EAE endothelial Endothelial Cells - metabolism Humans Inflammation - genetics JNK lung metastasis MAP Kinase Kinase Kinases - metabolism MAP3K8 Mice Neoplasm Metastasis Occludin Proto-Oncogene Proteins - metabolism Tpl2
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