Relationship between blood viscosity and no-reflow phenomenon in ST-segment elevation myocardial infarction performed in primary percutaneous coronary interventions
This study aimed to analyze the associations between no-reflow (NR) phenomenon development and whole-blood viscosity in patients with ST-elevated myocardial infarction. A total of 217 patients with ST-elevated myocardial infarction were included. whole-blood viscosity values were assessed using hema...
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| Veröffentlicht in: | Biomarkers in medicine 2021-06, Vol.15 (9), p.659-667 |
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| creator | Yildirim, Arafat Kucukosmanoglu, Mehmet Koyunsever, Nermin Y Cekici, Yusuf Belibagli, Mehmet C Kilic, Salih |
| description | This study aimed to analyze the associations between no-reflow (NR) phenomenon development and whole-blood viscosity in patients with ST-elevated myocardial infarction.
A total of 217 patients with ST-elevated myocardial infarction were included. whole-blood viscosity values were assessed using hematocrit and total protein values, and low shear rate (LSR) and high shear rate (HSR) were calculated.
The average LSR and HSR values of the study group were significantly higher than the control group (p |
| doi_str_mv | 10.2217/bmm-2020-0772 |
| format | Article |
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A total of 217 patients with ST-elevated myocardial infarction were included. whole-blood viscosity values were assessed using hematocrit and total protein values, and low shear rate (LSR) and high shear rate (HSR) were calculated.
The average LSR and HSR values of the study group were significantly higher than the control group (p < 0.001). Multivariate logistic regression analysis showed that both HSR (odds ratio: 4.957; p < 0.001) and LSR (odds ratio: 1.114; p < 0.001) were independent predictors for NR development.
This study found that increased blood viscosity was an independent predictor for NR development.
Following a heart attack, surgeons can attempt to repair the damage using a procedure called a percutaneous coronary intervention. In some cases, blood flow does not return to the heart tissue as expected (‘failure of reperfusion’) after this procedure, which is known as the no-reflow (NR) phenomenon. In this study, the researchers investigated whether there was a link between patients who had experienced a type of heart attack called an ST-elevated myocardial infarction (STEMI) and developed NR, and the viscosity (thickness) of their blood. The researchers looked at the viscosity of whole-blood samples from 98 STEMI patients with NR and 119 control individuals matched for age and gender. They found that whole-blood samples could be used to predict the likelihood of a STEMI patient experiencing NR.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2020-0772</identifier><identifier>PMID: 34039016</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Aged ; Blood Viscosity ; Case-Control Studies ; Humans ; Male ; Middle Aged ; no-reflow phenomenon ; No-Reflow Phenomenon - blood ; No-Reflow Phenomenon - pathology ; Percutaneous Coronary Intervention - methods ; primary percutaneous coronary intervention ; Risk Assessment - methods ; Risk Factors ; ST Elevation Myocardial Infarction - pathology ; ST Elevation Myocardial Infarction - surgery ; ST-elevated myocardial infarction ; whole-blood viscosity</subject><ispartof>Biomarkers in medicine, 2021-06, Vol.15 (9), p.659-667</ispartof><rights>2021 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-d211d4f3872f3be18b8b82611811082760741eed48a74272a92edef12f81889f3</citedby><cites>FETCH-LOGICAL-c343t-d211d4f3872f3be18b8b82611811082760741eed48a74272a92edef12f81889f3</cites><orcidid>0000-0002-2798-7488 ; 0000-0001-9186-3642 ; 0000-0002-0074-4611 ; 0000-0002-4585-3707 ; 0000-0002-3579-3747 ; 0000-0002-0058-1330</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34039016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yildirim, Arafat</creatorcontrib><creatorcontrib>Kucukosmanoglu, Mehmet</creatorcontrib><creatorcontrib>Koyunsever, Nermin Y</creatorcontrib><creatorcontrib>Cekici, Yusuf</creatorcontrib><creatorcontrib>Belibagli, Mehmet C</creatorcontrib><creatorcontrib>Kilic, Salih</creatorcontrib><title>Relationship between blood viscosity and no-reflow phenomenon in ST-segment elevation myocardial infarction performed in primary percutaneous coronary interventions</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>This study aimed to analyze the associations between no-reflow (NR) phenomenon development and whole-blood viscosity in patients with ST-elevated myocardial infarction.
A total of 217 patients with ST-elevated myocardial infarction were included. whole-blood viscosity values were assessed using hematocrit and total protein values, and low shear rate (LSR) and high shear rate (HSR) were calculated.
The average LSR and HSR values of the study group were significantly higher than the control group (p < 0.001). Multivariate logistic regression analysis showed that both HSR (odds ratio: 4.957; p < 0.001) and LSR (odds ratio: 1.114; p < 0.001) were independent predictors for NR development.
This study found that increased blood viscosity was an independent predictor for NR development.
Following a heart attack, surgeons can attempt to repair the damage using a procedure called a percutaneous coronary intervention. In some cases, blood flow does not return to the heart tissue as expected (‘failure of reperfusion’) after this procedure, which is known as the no-reflow (NR) phenomenon. In this study, the researchers investigated whether there was a link between patients who had experienced a type of heart attack called an ST-elevated myocardial infarction (STEMI) and developed NR, and the viscosity (thickness) of their blood. The researchers looked at the viscosity of whole-blood samples from 98 STEMI patients with NR and 119 control individuals matched for age and gender. They found that whole-blood samples could be used to predict the likelihood of a STEMI patient experiencing NR.</description><subject>Aged</subject><subject>Blood Viscosity</subject><subject>Case-Control Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>no-reflow phenomenon</subject><subject>No-Reflow Phenomenon - blood</subject><subject>No-Reflow Phenomenon - pathology</subject><subject>Percutaneous Coronary Intervention - methods</subject><subject>primary percutaneous coronary intervention</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>ST Elevation Myocardial Infarction - pathology</subject><subject>ST Elevation Myocardial Infarction - surgery</subject><subject>ST-elevated myocardial infarction</subject><subject>whole-blood viscosity</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v3CAQhlHVqvloj7lWHHMh5cNr2GMUJW2lSJXa9IwwHhIqGxzAu9r_0x9aHG9zqxBiZvTMq2FehC4YveKcyc_dOBJOOSVUSv4GnTK54YQKyd6-xq04QWc5_6Z0I2XL36MT0VCxpaw9RX9-wGCKjyE_-Ql3UPYAAXdDjD3e-Wxj9uWATehxiCSBG-IeT08Q4lhvwD7gnw8kw2NNC4YBdi9ieDxEa1LvzVARZ5J9qU6QXEwj9EvflPxo0mEp2rmYAHHO2MYUw1L1oUDaVdFltA_onTNDho_H9xz9urt9uPlK7r9_-XZzfU-saEQhPWesb5xQkjvRAVNdPbxlTDFGFZctlQ0D6BtlZMMlN1sOPTjGnWJKbZ04R5er7pTi8wy56LGuAIZhnU7zjRCCtXSjKkpW1KaYc12MPv5HM6oXY3Q1Ri_G6MWYyn86Ss9dXcAr_c-JCmxXwM1lTpCth2BBr1nt8NYH-I_4XyO1oYs</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Yildirim, Arafat</creator><creator>Kucukosmanoglu, Mehmet</creator><creator>Koyunsever, Nermin Y</creator><creator>Cekici, Yusuf</creator><creator>Belibagli, Mehmet C</creator><creator>Kilic, Salih</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2798-7488</orcidid><orcidid>https://orcid.org/0000-0001-9186-3642</orcidid><orcidid>https://orcid.org/0000-0002-0074-4611</orcidid><orcidid>https://orcid.org/0000-0002-4585-3707</orcidid><orcidid>https://orcid.org/0000-0002-3579-3747</orcidid><orcidid>https://orcid.org/0000-0002-0058-1330</orcidid></search><sort><creationdate>20210601</creationdate><title>Relationship between blood viscosity and no-reflow phenomenon in ST-segment elevation myocardial infarction performed in primary percutaneous coronary interventions</title><author>Yildirim, Arafat ; Kucukosmanoglu, Mehmet ; Koyunsever, Nermin Y ; Cekici, Yusuf ; Belibagli, Mehmet C ; Kilic, Salih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-d211d4f3872f3be18b8b82611811082760741eed48a74272a92edef12f81889f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Blood Viscosity</topic><topic>Case-Control Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>no-reflow phenomenon</topic><topic>No-Reflow Phenomenon - blood</topic><topic>No-Reflow Phenomenon - pathology</topic><topic>Percutaneous Coronary Intervention - methods</topic><topic>primary percutaneous coronary intervention</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>ST Elevation Myocardial Infarction - pathology</topic><topic>ST Elevation Myocardial Infarction - surgery</topic><topic>ST-elevated myocardial infarction</topic><topic>whole-blood viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yildirim, Arafat</creatorcontrib><creatorcontrib>Kucukosmanoglu, Mehmet</creatorcontrib><creatorcontrib>Koyunsever, Nermin Y</creatorcontrib><creatorcontrib>Cekici, Yusuf</creatorcontrib><creatorcontrib>Belibagli, Mehmet C</creatorcontrib><creatorcontrib>Kilic, Salih</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yildirim, Arafat</au><au>Kucukosmanoglu, Mehmet</au><au>Koyunsever, Nermin Y</au><au>Cekici, Yusuf</au><au>Belibagli, Mehmet C</au><au>Kilic, Salih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between blood viscosity and no-reflow phenomenon in ST-segment elevation myocardial infarction performed in primary percutaneous coronary interventions</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>15</volume><issue>9</issue><spage>659</spage><epage>667</epage><pages>659-667</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>This study aimed to analyze the associations between no-reflow (NR) phenomenon development and whole-blood viscosity in patients with ST-elevated myocardial infarction.
A total of 217 patients with ST-elevated myocardial infarction were included. whole-blood viscosity values were assessed using hematocrit and total protein values, and low shear rate (LSR) and high shear rate (HSR) were calculated.
The average LSR and HSR values of the study group were significantly higher than the control group (p < 0.001). Multivariate logistic regression analysis showed that both HSR (odds ratio: 4.957; p < 0.001) and LSR (odds ratio: 1.114; p < 0.001) were independent predictors for NR development.
This study found that increased blood viscosity was an independent predictor for NR development.
Following a heart attack, surgeons can attempt to repair the damage using a procedure called a percutaneous coronary intervention. In some cases, blood flow does not return to the heart tissue as expected (‘failure of reperfusion’) after this procedure, which is known as the no-reflow (NR) phenomenon. In this study, the researchers investigated whether there was a link between patients who had experienced a type of heart attack called an ST-elevated myocardial infarction (STEMI) and developed NR, and the viscosity (thickness) of their blood. The researchers looked at the viscosity of whole-blood samples from 98 STEMI patients with NR and 119 control individuals matched for age and gender. They found that whole-blood samples could be used to predict the likelihood of a STEMI patient experiencing NR.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>34039016</pmid><doi>10.2217/bmm-2020-0772</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2798-7488</orcidid><orcidid>https://orcid.org/0000-0001-9186-3642</orcidid><orcidid>https://orcid.org/0000-0002-0074-4611</orcidid><orcidid>https://orcid.org/0000-0002-4585-3707</orcidid><orcidid>https://orcid.org/0000-0002-3579-3747</orcidid><orcidid>https://orcid.org/0000-0002-0058-1330</orcidid></addata></record> |
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| subjects | Aged Blood Viscosity Case-Control Studies Humans Male Middle Aged no-reflow phenomenon No-Reflow Phenomenon - blood No-Reflow Phenomenon - pathology Percutaneous Coronary Intervention - methods primary percutaneous coronary intervention Risk Assessment - methods Risk Factors ST Elevation Myocardial Infarction - pathology ST Elevation Myocardial Infarction - surgery ST-elevated myocardial infarction whole-blood viscosity |
| title | Relationship between blood viscosity and no-reflow phenomenon in ST-segment elevation myocardial infarction performed in primary percutaneous coronary interventions |
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