Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats
The present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84 Rattus norvegicus had partial transection of the calcaneus tendon (PTCT) and...
Gespeichert in:
| Veröffentlicht in: | Lasers in medical science 2022-03, Vol.37 (2), p.971-981 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 981 |
|---|---|
| container_issue | 2 |
| container_start_page | 971 |
| container_title | Lasers in medical science |
| container_volume | 37 |
| creator | de Freitas Dutra Júnior, Enéas Hidd, Sílvia Maria Cardoso Magalhães Amaral, Marcello Magri Filho, Antonio Luiz Martins Maia Assis, Livia Ferreira, Rui Seabra Barraviera, Benedito Martignago, Cintia Cristina Santi Figueredo-Silva, José de Oliveira, Rauirys Alencar Tim, Carla Roberta |
| description | The present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84
Rattus norvegicus
had partial transection of the calcaneus tendon (PTCT) and were randomly divided into: control (CG); heterologous fibrin biopolymer (HFB); photobiomodulation (PBM); heterologous fibrin biopolymer + photobiomodulation (HFB + PBM). The animals received HFB immediately after PTCT, while PBM (660 nm, 40 mW, 0.23 J) started 24 h post injury and followed every 24 h for 7, 14, and 21 days. The results of the edema volume showed that after 24 h of PTCT, there was no statistical difference among the groups. After 7, 14, and 21 days, it was observed that the treatment groups were effective in reducing edema when compared to the control. The HFB had the highest edema volume reduction after 21 days of treatment. The treatment groups did not induce tissue necrosis or infections on the histopathological analysis. Tenocyte proliferation, granulation tissue, and collagen formation were observed in the PTCT area in the HFB and HFB + PBM groups, which culminated a better repair process when compared to the CG in the 3 experimental periods. Interestingly, the PBM group revealed, in histological analysis, major tendon injury after 7 days; however, in the periods of 14 and 21 days, the PBM had a better repair process compared to the CG. In the quantification of collagen, there was no statistical difference between the groups in the 3 experimental periods. The findings suggest that the HFB and PBM treatments, isolated or associated, were effective in reducing the volume of the edema, stimulating the repair process. However, the use of HFB alone was more effective in promoting the tendon repair process. Thus, the present study consolidates previous studies of tendon repair with this new HFB. Future clinical trials will be needed to validate this proposal. |
| doi_str_mv | 10.1007/s10103-021-03341-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2533314469</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2533314469</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-2726f85c9691499cb842682de889dbe696c321fb82f9a15fa1c4ab31bec56a93</originalsourceid><addsrcrecordid>eNp9kTFvHCEQhVGUKD47-QMpIqQ0bjbHAMtBaVl2HMlSmivSIZZlfZx2YQOs7Pv34XJOLLlINdLM997M6CH0CchXIGSzzkCAsIZQaAhjHJqnN2gFnLWNIPznW7QiVMhGKgpn6DznPSGwEcDeozPGCQcBaoUO2-RMmVwoOA54Nql4M2If9ks6HDtl57A1ozXBLRkXF_oY8KMvO7xzxaU4xodYB4Pvkg-483GO42FyCZvQr2PC8y6WWNtT7JfRFF_VlUum5A_o3WDG7D4-1wu0vb3ZXt819z--fb--um8s27SloRsqBtlaJRRwpWwnef2K9k5K1XdOKGEZhaGTdFAG2sGA5aZj0DnbCqPYBbo82c4p_lpcLnry2bpxrB_VyzVtGWPAuTiiX16h-7ikUI_TVDDJACQXlaInyqaYc3KDnpOfTDpoIPqYiz7lomsu-k8u-qmKPj9bL93k-n-Sv0FUgJ2AXEfhwaWX3f-x_Q1q3ZsF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2638311846</pqid></control><display><type>article</type><title>Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>de Freitas Dutra Júnior, Enéas ; Hidd, Sílvia Maria Cardoso Magalhães ; Amaral, Marcello Magri ; Filho, Antonio Luiz Martins Maia ; Assis, Livia ; Ferreira, Rui Seabra ; Barraviera, Benedito ; Martignago, Cintia Cristina Santi ; Figueredo-Silva, José ; de Oliveira, Rauirys Alencar ; Tim, Carla Roberta</creator><creatorcontrib>de Freitas Dutra Júnior, Enéas ; Hidd, Sílvia Maria Cardoso Magalhães ; Amaral, Marcello Magri ; Filho, Antonio Luiz Martins Maia ; Assis, Livia ; Ferreira, Rui Seabra ; Barraviera, Benedito ; Martignago, Cintia Cristina Santi ; Figueredo-Silva, José ; de Oliveira, Rauirys Alencar ; Tim, Carla Roberta</creatorcontrib><description>The present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84
Rattus norvegicus
had partial transection of the calcaneus tendon (PTCT) and were randomly divided into: control (CG); heterologous fibrin biopolymer (HFB); photobiomodulation (PBM); heterologous fibrin biopolymer + photobiomodulation (HFB + PBM). The animals received HFB immediately after PTCT, while PBM (660 nm, 40 mW, 0.23 J) started 24 h post injury and followed every 24 h for 7, 14, and 21 days. The results of the edema volume showed that after 24 h of PTCT, there was no statistical difference among the groups. After 7, 14, and 21 days, it was observed that the treatment groups were effective in reducing edema when compared to the control. The HFB had the highest edema volume reduction after 21 days of treatment. The treatment groups did not induce tissue necrosis or infections on the histopathological analysis. Tenocyte proliferation, granulation tissue, and collagen formation were observed in the PTCT area in the HFB and HFB + PBM groups, which culminated a better repair process when compared to the CG in the 3 experimental periods. Interestingly, the PBM group revealed, in histological analysis, major tendon injury after 7 days; however, in the periods of 14 and 21 days, the PBM had a better repair process compared to the CG. In the quantification of collagen, there was no statistical difference between the groups in the 3 experimental periods. The findings suggest that the HFB and PBM treatments, isolated or associated, were effective in reducing the volume of the edema, stimulating the repair process. However, the use of HFB alone was more effective in promoting the tendon repair process. Thus, the present study consolidates previous studies of tendon repair with this new HFB. Future clinical trials will be needed to validate this proposal.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-021-03341-x</identifier><identifier>PMID: 34041619</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Achilles Tendon ; Animals ; Biopolymers ; Calcaneus ; Clinical trials ; Collagen ; Dentistry ; Edema ; Fibrin ; Granulation ; Injuries ; Injury analysis ; Lasers ; Light therapy ; Low-Level Light Therapy ; Medicine ; Medicine & Public Health ; Necrosis ; Optical Devices ; Optics ; Original Article ; Orthopedics ; Photonics ; Quantum Optics ; Rats ; Rats, Wistar ; Repair ; Statistics</subject><ispartof>Lasers in medical science, 2022-03, Vol.37 (2), p.971-981</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-2726f85c9691499cb842682de889dbe696c321fb82f9a15fa1c4ab31bec56a93</citedby><cites>FETCH-LOGICAL-c375t-2726f85c9691499cb842682de889dbe696c321fb82f9a15fa1c4ab31bec56a93</cites><orcidid>0000-0002-4745-9375</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-021-03341-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-021-03341-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34041619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Freitas Dutra Júnior, Enéas</creatorcontrib><creatorcontrib>Hidd, Sílvia Maria Cardoso Magalhães</creatorcontrib><creatorcontrib>Amaral, Marcello Magri</creatorcontrib><creatorcontrib>Filho, Antonio Luiz Martins Maia</creatorcontrib><creatorcontrib>Assis, Livia</creatorcontrib><creatorcontrib>Ferreira, Rui Seabra</creatorcontrib><creatorcontrib>Barraviera, Benedito</creatorcontrib><creatorcontrib>Martignago, Cintia Cristina Santi</creatorcontrib><creatorcontrib>Figueredo-Silva, José</creatorcontrib><creatorcontrib>de Oliveira, Rauirys Alencar</creatorcontrib><creatorcontrib>Tim, Carla Roberta</creatorcontrib><title>Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>The present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84
Rattus norvegicus
had partial transection of the calcaneus tendon (PTCT) and were randomly divided into: control (CG); heterologous fibrin biopolymer (HFB); photobiomodulation (PBM); heterologous fibrin biopolymer + photobiomodulation (HFB + PBM). The animals received HFB immediately after PTCT, while PBM (660 nm, 40 mW, 0.23 J) started 24 h post injury and followed every 24 h for 7, 14, and 21 days. The results of the edema volume showed that after 24 h of PTCT, there was no statistical difference among the groups. After 7, 14, and 21 days, it was observed that the treatment groups were effective in reducing edema when compared to the control. The HFB had the highest edema volume reduction after 21 days of treatment. The treatment groups did not induce tissue necrosis or infections on the histopathological analysis. Tenocyte proliferation, granulation tissue, and collagen formation were observed in the PTCT area in the HFB and HFB + PBM groups, which culminated a better repair process when compared to the CG in the 3 experimental periods. Interestingly, the PBM group revealed, in histological analysis, major tendon injury after 7 days; however, in the periods of 14 and 21 days, the PBM had a better repair process compared to the CG. In the quantification of collagen, there was no statistical difference between the groups in the 3 experimental periods. The findings suggest that the HFB and PBM treatments, isolated or associated, were effective in reducing the volume of the edema, stimulating the repair process. However, the use of HFB alone was more effective in promoting the tendon repair process. Thus, the present study consolidates previous studies of tendon repair with this new HFB. Future clinical trials will be needed to validate this proposal.</description><subject>Achilles Tendon</subject><subject>Animals</subject><subject>Biopolymers</subject><subject>Calcaneus</subject><subject>Clinical trials</subject><subject>Collagen</subject><subject>Dentistry</subject><subject>Edema</subject><subject>Fibrin</subject><subject>Granulation</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Lasers</subject><subject>Light therapy</subject><subject>Low-Level Light Therapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Necrosis</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Photonics</subject><subject>Quantum Optics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Repair</subject><subject>Statistics</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kTFvHCEQhVGUKD47-QMpIqQ0bjbHAMtBaVl2HMlSmivSIZZlfZx2YQOs7Pv34XJOLLlINdLM997M6CH0CchXIGSzzkCAsIZQaAhjHJqnN2gFnLWNIPznW7QiVMhGKgpn6DznPSGwEcDeozPGCQcBaoUO2-RMmVwoOA54Nql4M2If9ks6HDtl57A1ozXBLRkXF_oY8KMvO7xzxaU4xodYB4Pvkg-483GO42FyCZvQr2PC8y6WWNtT7JfRFF_VlUum5A_o3WDG7D4-1wu0vb3ZXt819z--fb--um8s27SloRsqBtlaJRRwpWwnef2K9k5K1XdOKGEZhaGTdFAG2sGA5aZj0DnbCqPYBbo82c4p_lpcLnry2bpxrB_VyzVtGWPAuTiiX16h-7ikUI_TVDDJACQXlaInyqaYc3KDnpOfTDpoIPqYiz7lomsu-k8u-qmKPj9bL93k-n-Sv0FUgJ2AXEfhwaWX3f-x_Q1q3ZsF</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>de Freitas Dutra Júnior, Enéas</creator><creator>Hidd, Sílvia Maria Cardoso Magalhães</creator><creator>Amaral, Marcello Magri</creator><creator>Filho, Antonio Luiz Martins Maia</creator><creator>Assis, Livia</creator><creator>Ferreira, Rui Seabra</creator><creator>Barraviera, Benedito</creator><creator>Martignago, Cintia Cristina Santi</creator><creator>Figueredo-Silva, José</creator><creator>de Oliveira, Rauirys Alencar</creator><creator>Tim, Carla Roberta</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4745-9375</orcidid></search><sort><creationdate>20220301</creationdate><title>Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats</title><author>de Freitas Dutra Júnior, Enéas ; Hidd, Sílvia Maria Cardoso Magalhães ; Amaral, Marcello Magri ; Filho, Antonio Luiz Martins Maia ; Assis, Livia ; Ferreira, Rui Seabra ; Barraviera, Benedito ; Martignago, Cintia Cristina Santi ; Figueredo-Silva, José ; de Oliveira, Rauirys Alencar ; Tim, Carla Roberta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-2726f85c9691499cb842682de889dbe696c321fb82f9a15fa1c4ab31bec56a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Achilles Tendon</topic><topic>Animals</topic><topic>Biopolymers</topic><topic>Calcaneus</topic><topic>Clinical trials</topic><topic>Collagen</topic><topic>Dentistry</topic><topic>Edema</topic><topic>Fibrin</topic><topic>Granulation</topic><topic>Injuries</topic><topic>Injury analysis</topic><topic>Lasers</topic><topic>Light therapy</topic><topic>Low-Level Light Therapy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Necrosis</topic><topic>Optical Devices</topic><topic>Optics</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Photonics</topic><topic>Quantum Optics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Repair</topic><topic>Statistics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Freitas Dutra Júnior, Enéas</creatorcontrib><creatorcontrib>Hidd, Sílvia Maria Cardoso Magalhães</creatorcontrib><creatorcontrib>Amaral, Marcello Magri</creatorcontrib><creatorcontrib>Filho, Antonio Luiz Martins Maia</creatorcontrib><creatorcontrib>Assis, Livia</creatorcontrib><creatorcontrib>Ferreira, Rui Seabra</creatorcontrib><creatorcontrib>Barraviera, Benedito</creatorcontrib><creatorcontrib>Martignago, Cintia Cristina Santi</creatorcontrib><creatorcontrib>Figueredo-Silva, José</creatorcontrib><creatorcontrib>de Oliveira, Rauirys Alencar</creatorcontrib><creatorcontrib>Tim, Carla Roberta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Freitas Dutra Júnior, Enéas</au><au>Hidd, Sílvia Maria Cardoso Magalhães</au><au>Amaral, Marcello Magri</au><au>Filho, Antonio Luiz Martins Maia</au><au>Assis, Livia</au><au>Ferreira, Rui Seabra</au><au>Barraviera, Benedito</au><au>Martignago, Cintia Cristina Santi</au><au>Figueredo-Silva, José</au><au>de Oliveira, Rauirys Alencar</au><au>Tim, Carla Roberta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats</atitle><jtitle>Lasers in medical science</jtitle><stitle>Lasers Med Sci</stitle><addtitle>Lasers Med Sci</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>37</volume><issue>2</issue><spage>971</spage><epage>981</epage><pages>971-981</pages><issn>0268-8921</issn><eissn>1435-604X</eissn><abstract>The present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84
Rattus norvegicus
had partial transection of the calcaneus tendon (PTCT) and were randomly divided into: control (CG); heterologous fibrin biopolymer (HFB); photobiomodulation (PBM); heterologous fibrin biopolymer + photobiomodulation (HFB + PBM). The animals received HFB immediately after PTCT, while PBM (660 nm, 40 mW, 0.23 J) started 24 h post injury and followed every 24 h for 7, 14, and 21 days. The results of the edema volume showed that after 24 h of PTCT, there was no statistical difference among the groups. After 7, 14, and 21 days, it was observed that the treatment groups were effective in reducing edema when compared to the control. The HFB had the highest edema volume reduction after 21 days of treatment. The treatment groups did not induce tissue necrosis or infections on the histopathological analysis. Tenocyte proliferation, granulation tissue, and collagen formation were observed in the PTCT area in the HFB and HFB + PBM groups, which culminated a better repair process when compared to the CG in the 3 experimental periods. Interestingly, the PBM group revealed, in histological analysis, major tendon injury after 7 days; however, in the periods of 14 and 21 days, the PBM had a better repair process compared to the CG. In the quantification of collagen, there was no statistical difference between the groups in the 3 experimental periods. The findings suggest that the HFB and PBM treatments, isolated or associated, were effective in reducing the volume of the edema, stimulating the repair process. However, the use of HFB alone was more effective in promoting the tendon repair process. Thus, the present study consolidates previous studies of tendon repair with this new HFB. Future clinical trials will be needed to validate this proposal.</abstract><cop>London</cop><pub>Springer London</pub><pmid>34041619</pmid><doi>10.1007/s10103-021-03341-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4745-9375</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-8921 |
| ispartof | Lasers in medical science, 2022-03, Vol.37 (2), p.971-981 |
| issn | 0268-8921 1435-604X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2533314469 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Achilles Tendon Animals Biopolymers Calcaneus Clinical trials Collagen Dentistry Edema Fibrin Granulation Injuries Injury analysis Lasers Light therapy Low-Level Light Therapy Medicine Medicine & Public Health Necrosis Optical Devices Optics Original Article Orthopedics Photonics Quantum Optics Rats Rats, Wistar Repair Statistics |
| title | Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T15%3A15%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Treatment%20of%20partial%20injury%20of%20the%20calcaneus%20tendon%20with%20heterologous%20fibrin%20biopolymer%20and/or%20photobiomodulation%20in%20rats&rft.jtitle=Lasers%20in%20medical%20science&rft.au=de%20Freitas%20Dutra%20J%C3%BAnior,%20En%C3%A9as&rft.date=2022-03-01&rft.volume=37&rft.issue=2&rft.spage=971&rft.epage=981&rft.pages=971-981&rft.issn=0268-8921&rft.eissn=1435-604X&rft_id=info:doi/10.1007/s10103-021-03341-x&rft_dat=%3Cproquest_cross%3E2533314469%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2638311846&rft_id=info:pmid/34041619&rfr_iscdi=true |