SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1

Breast cancer is the most common cancer in women and its incidence rates are rapidly increasing in China. Understanding the molecular mechanisms of breast cancer tumorigenesis enables the development of novel therapeutic strategies. SEC61G is a subunit of the endoplasmic reticulum translocon that pl...

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Veröffentlicht in:	Cell death & disease 2021-05, Vol.12 (6), p.550-14, Article 550
Hauptverfasser:	Ma, Jingjing, He, Zhixian, Zhang, Hongwei, zhang, Wensheng, Gao, Sheng, Ni, Xiaojian
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 38 38/109 38/89 45 45/77 631/67/1347 692/53/2422 Animals Antibodies Apoptosis Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Biology Cell Culture Cell growth Cell Line, Tumor Cell migration Cell proliferation E2F1 Transcription Factor - genetics E2F1 Transcription Factor - metabolism Endoplasmic reticulum Female Genomes Glycolysis Heterografts Humans Immunology Life Sciences Life Sciences & Biomedicine MCF-7 Cells Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Molecular modelling Neoplasm Metastasis Prognosis Science & Technology SEC Translocation Channels - metabolism Therapeutic targets Transcription, Genetic Tumorigenesis Xenografts
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