Angiotensin involvement in kidney injury induced by rheumatoid arthritis in rat

Renal injury induced by rheumatoid arthritis is not clear and may be related to the angiotensin II. We aim to investigate the adjuvant‐induced arthritis (AIA) injury in rat kidney, focusing the angiotensin II/AT1 pathway. Male Wistar rats were allocated in to three groups: Control, AIA and AIA plus...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2021-09, Vol.48 (9), p.1271-1279
Hauptverfasser:	Carlos, Carla Patrícia, Carvalho, Enzo Prandi, Angeli Junior, Euradir Vitório, Garcia Filho, Glayber Falcão, Doná, João Pedro Lot, Batanero, Rodrigo Piloto de Oliveira, Guena, Rafael de Oliveira, Agren, Camila, Baptista, Maria Alice Sperto Ferreira, Bizotto, Thaís Santana Gastardelo, Cury, Patricia Maluf, Chies, Agnaldo Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant arthritis angiotensin Angiotensin AT1 receptors Angiotensin II Angiotensin receptors Animals Apoptosis Apoptosis - drug effects Arthritis Arthritis, Rheumatoid - complications Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Caspase Creatinine Depuration Growth factors Immunization Injection Injury analysis Injury prevention kidney Kidney - drug effects Kidney - metabolism Kidney - pathology Kidneys Losartan - pharmacology Macrophages Male Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Oxidative stress Oxidative Stress - drug effects Plasma Plasma levels rat Rats Rats, Wistar Receptor, Angiotensin, Type 1 - metabolism Receptors Renal function Rheumatoid arthritis Thiobarbituric acid Transforming Growth Factor beta - metabolism Transforming growth factor-b Tuberculosis Urea Uric acid
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