Enzyme/GSH dual-responsive biodegradable nanohybrid for spatiotemporally specific photodynamic and hypoxia-augmented therapy against tumors

An enzyme/GSH dual-responsive biodegradable drug delivery system was developed by using mesoporous organosilica co-loaded with photosensitizer (IR820) and pro-drug (TPZ) for spatiotemporally PDT and PDT-induced hypoxic-activated chemotherapy, hyaluronic acid as capping agent and tumor targeting unit...

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Veröffentlicht in:	International journal of pharmaceutics 2021-06, Vol.603, p.120730-120730, Article 120730
Hauptverfasser:	Cheng, Di, Ji, Yuejia, Wang, Bin, Jin, Tongxia, Xu, Yufang, Qian, Xuhong, Zhu, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradable silica Hypoxic-activated prodrug PDT-induced hypoxia Spatiotemporally therapy
Online-Zugang:	Volltext
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