The association between blood pressure variability and hip or vertebral fracture risk: A population-based study
The present study evaluated the association between blood pressure variability and the risk of hip/vertebral fractures in middle aged and elderly patients. This was a retrospective observational study of patients attending family medicine outpatient clinics, recruited from 1st January 2000 to 31st D...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2021-09, Vol.150, p.116015-116015, Article 116015 |
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| container_title | Bone (New York, N.Y.) |
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| creator | Zhou, Jiandong Li, Helen Chang, Carlin Wu, William Ka Kei Wang, Xiansong Liu, Tong Cheung, Bernard Man Yung Zhang, Qingpeng Lee, Sharen Tse, Gary |
| description | The present study evaluated the association between blood pressure variability and the risk of hip/vertebral fractures in middle aged and elderly patients.
This was a retrospective observational study of patients attending family medicine outpatient clinics, recruited from 1st January 2000 to 31st December 2003 and were followed up until 31st December 2019. Standard deviation (SD), root mean square (RMS), coefficient of variation (CV) and a variability score (defined as the number of changes in blood pressure (diastolic and systolic) of 5 mm Hg or more) were used as measures of blood pressure variability. The primary outcome was a composite of new onset hip or vertebral fractures.
A total of 57,810 patients were included. Over a median follow-up of 5894 days (interquartile range: 3505–6487), 3285 patients (5.68%) developed new onset hip/vertebral fractures. The crude incidence rates were 4.95%, 5.31%, and 7.2% for diastolic blood pressure-CV and 5.0%, 5.28%, and 7.08% for systolic blood pressure-CV in the first, second, and third tertiles, respectively. Survival analysis demonstrated differences in hip/vertebral fracture amongst the tertiles of systolic and diastolic blood pressure variability (P |
| doi_str_mv | 10.1016/j.bone.2021.116015 |
| format | Article |
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This was a retrospective observational study of patients attending family medicine outpatient clinics, recruited from 1st January 2000 to 31st December 2003 and were followed up until 31st December 2019. Standard deviation (SD), root mean square (RMS), coefficient of variation (CV) and a variability score (defined as the number of changes in blood pressure (diastolic and systolic) of 5 mm Hg or more) were used as measures of blood pressure variability. The primary outcome was a composite of new onset hip or vertebral fractures.
A total of 57,810 patients were included. Over a median follow-up of 5894 days (interquartile range: 3505–6487), 3285 patients (5.68%) developed new onset hip/vertebral fractures. The crude incidence rates were 4.95%, 5.31%, and 7.2% for diastolic blood pressure-CV and 5.0%, 5.28%, and 7.08% for systolic blood pressure-CV in the first, second, and third tertiles, respectively. Survival analysis demonstrated differences in hip/vertebral fracture amongst the tertiles of systolic and diastolic blood pressure variability (P < 0.0001).
Measures of blood pressure variability were significantly associated with incident hip/vertebral fractures. They can be incorporated into existing clinical scores to improve risk stratification.
•Higher blood pressure variability is linked to an increased risk of hip/vertebral fractures after adjusting for confounders•Demographics, comorbidities and medications prescribed all influence blood pressure variability</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2021.116015</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Association ; Blood pressure variability ; Hip fracture ; Vertebral fracture</subject><ispartof>Bone (New York, N.Y.), 2021-09, Vol.150, p.116015-116015, Article 116015</ispartof><rights>2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-c2419a780ee11de9c2a47631ac219d29c101d6c3b3ba705546489889ba1929133</citedby><cites>FETCH-LOGICAL-c333t-c2419a780ee11de9c2a47631ac219d29c101d6c3b3ba705546489889ba1929133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bone.2021.116015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Zhou, Jiandong</creatorcontrib><creatorcontrib>Li, Helen</creatorcontrib><creatorcontrib>Chang, Carlin</creatorcontrib><creatorcontrib>Wu, William Ka Kei</creatorcontrib><creatorcontrib>Wang, Xiansong</creatorcontrib><creatorcontrib>Liu, Tong</creatorcontrib><creatorcontrib>Cheung, Bernard Man Yung</creatorcontrib><creatorcontrib>Zhang, Qingpeng</creatorcontrib><creatorcontrib>Lee, Sharen</creatorcontrib><creatorcontrib>Tse, Gary</creatorcontrib><title>The association between blood pressure variability and hip or vertebral fracture risk: A population-based study</title><title>Bone (New York, N.Y.)</title><description>The present study evaluated the association between blood pressure variability and the risk of hip/vertebral fractures in middle aged and elderly patients.
This was a retrospective observational study of patients attending family medicine outpatient clinics, recruited from 1st January 2000 to 31st December 2003 and were followed up until 31st December 2019. Standard deviation (SD), root mean square (RMS), coefficient of variation (CV) and a variability score (defined as the number of changes in blood pressure (diastolic and systolic) of 5 mm Hg or more) were used as measures of blood pressure variability. The primary outcome was a composite of new onset hip or vertebral fractures.
A total of 57,810 patients were included. Over a median follow-up of 5894 days (interquartile range: 3505–6487), 3285 patients (5.68%) developed new onset hip/vertebral fractures. The crude incidence rates were 4.95%, 5.31%, and 7.2% for diastolic blood pressure-CV and 5.0%, 5.28%, and 7.08% for systolic blood pressure-CV in the first, second, and third tertiles, respectively. Survival analysis demonstrated differences in hip/vertebral fracture amongst the tertiles of systolic and diastolic blood pressure variability (P < 0.0001).
Measures of blood pressure variability were significantly associated with incident hip/vertebral fractures. They can be incorporated into existing clinical scores to improve risk stratification.
•Higher blood pressure variability is linked to an increased risk of hip/vertebral fractures after adjusting for confounders•Demographics, comorbidities and medications prescribed all influence blood pressure variability</description><subject>Association</subject><subject>Blood pressure variability</subject><subject>Hip fracture</subject><subject>Vertebral fracture</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOAzEURC0EEiHwA1QuaTb42vsyookiXlIkmlBbXvtGcdisF9sblL9nQ6ipppkz0hxCboHNgEF5v501vsMZZxxmACWD4oxMoK5ExqtSnJNJXRVlJnjNL8lVjFvGmJAVTIhfbZDqGL1xOjnf0QbTN-KYrfeW9gFjHALSvQ5ON6516UB1Z-nG9dQHuseQsAm6peugTTo2g4ufD3ROe98P7e9m1uiIlsY02MM1uVjrNuLNX07Jx_PTavGaLd9f3hbzZWaEECkzPAepq5ohAliUhut8PALacJCWSzO-tqURjWh0xYoiL_Na1rVsNEguQYgpuTvt9sF_DRiT2rlosG11h36IiheC8xGDfKzyU9UEH2PAteqD2-lwUMDU0a7aqqNddbSrTnZH6PEE4Xhi7zCoaBx2Bq0LaJKy3v2H_wAv5YPY</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Zhou, Jiandong</creator><creator>Li, Helen</creator><creator>Chang, Carlin</creator><creator>Wu, William Ka Kei</creator><creator>Wang, Xiansong</creator><creator>Liu, Tong</creator><creator>Cheung, Bernard Man Yung</creator><creator>Zhang, Qingpeng</creator><creator>Lee, Sharen</creator><creator>Tse, Gary</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>The association between blood pressure variability and hip or vertebral fracture risk: A population-based study</title><author>Zhou, Jiandong ; Li, Helen ; Chang, Carlin ; Wu, William Ka Kei ; Wang, Xiansong ; Liu, Tong ; Cheung, Bernard Man Yung ; Zhang, Qingpeng ; Lee, Sharen ; Tse, Gary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-c2419a780ee11de9c2a47631ac219d29c101d6c3b3ba705546489889ba1929133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Association</topic><topic>Blood pressure variability</topic><topic>Hip fracture</topic><topic>Vertebral fracture</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Jiandong</creatorcontrib><creatorcontrib>Li, Helen</creatorcontrib><creatorcontrib>Chang, Carlin</creatorcontrib><creatorcontrib>Wu, William Ka Kei</creatorcontrib><creatorcontrib>Wang, Xiansong</creatorcontrib><creatorcontrib>Liu, Tong</creatorcontrib><creatorcontrib>Cheung, Bernard Man Yung</creatorcontrib><creatorcontrib>Zhang, Qingpeng</creatorcontrib><creatorcontrib>Lee, Sharen</creatorcontrib><creatorcontrib>Tse, Gary</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Jiandong</au><au>Li, Helen</au><au>Chang, Carlin</au><au>Wu, William Ka Kei</au><au>Wang, Xiansong</au><au>Liu, Tong</au><au>Cheung, Bernard Man Yung</au><au>Zhang, Qingpeng</au><au>Lee, Sharen</au><au>Tse, Gary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between blood pressure variability and hip or vertebral fracture risk: A population-based study</atitle><jtitle>Bone (New York, N.Y.)</jtitle><date>2021-09</date><risdate>2021</risdate><volume>150</volume><spage>116015</spage><epage>116015</epage><pages>116015-116015</pages><artnum>116015</artnum><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>The present study evaluated the association between blood pressure variability and the risk of hip/vertebral fractures in middle aged and elderly patients.
This was a retrospective observational study of patients attending family medicine outpatient clinics, recruited from 1st January 2000 to 31st December 2003 and were followed up until 31st December 2019. Standard deviation (SD), root mean square (RMS), coefficient of variation (CV) and a variability score (defined as the number of changes in blood pressure (diastolic and systolic) of 5 mm Hg or more) were used as measures of blood pressure variability. The primary outcome was a composite of new onset hip or vertebral fractures.
A total of 57,810 patients were included. Over a median follow-up of 5894 days (interquartile range: 3505–6487), 3285 patients (5.68%) developed new onset hip/vertebral fractures. The crude incidence rates were 4.95%, 5.31%, and 7.2% for diastolic blood pressure-CV and 5.0%, 5.28%, and 7.08% for systolic blood pressure-CV in the first, second, and third tertiles, respectively. Survival analysis demonstrated differences in hip/vertebral fracture amongst the tertiles of systolic and diastolic blood pressure variability (P < 0.0001).
Measures of blood pressure variability were significantly associated with incident hip/vertebral fractures. They can be incorporated into existing clinical scores to improve risk stratification.
•Higher blood pressure variability is linked to an increased risk of hip/vertebral fractures after adjusting for confounders•Demographics, comorbidities and medications prescribed all influence blood pressure variability</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.bone.2021.116015</doi><tpages>1</tpages></addata></record> |
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| ispartof | Bone (New York, N.Y.), 2021-09, Vol.150, p.116015-116015, Article 116015 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Collection |
| subjects | Association Blood pressure variability Hip fracture Vertebral fracture |
| title | The association between blood pressure variability and hip or vertebral fracture risk: A population-based study |
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