Blockade of platelet glycoprotein receptor Ib ameliorates blood-brain barrier disruption following ischemic stroke via Epac pathway

Glycoprotein (GP) Ib is a platelet membrane receptor complex exposed to vascular injury, proposed as an effective target for stroke therapy. Previously, we have observed that the GPIb antagonist anfibatide (ANF) could mitigate blood-brain barrier (BBB) disruption following cerebral ischemia/reperfus...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-08, Vol.140, p.111698-111698, Article 111698
Hauptverfasser:	Chu, Wei, Sun, Xuemei, Zhu, Xiaoxiao, Zhao, Yu chen, Zhang, Jingcheng, Kong, Qin, Zhou, Lanlan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anfibatide Blood-brain barrier Cerebral ischemia/reperfusion Epac Glycoprotein Ib
Online-Zugang:	Volltext
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