Aptamer-Based Logic Computing Reaction on Living Cells to Enable Non-Antibody Immune Checkpoint Blockade Therapy

Precise and lasting immune checkpoint blockade (ICB) therapy with high objective response rate remains a significant challenge in clinical trials. We thus report the development of an aptamer-based logic computing reaction to covalently conjugate immune checkpoint antagonizing aptamers (e.g., aPDL1...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2021-06, Vol.143 (22), p.8391-8401
Hauptverfasser:	Yang, Yu, Xu, Jun, Sun, Yang, Mo, Liuting, Liu, Bo, Pan, Xiaoshu, Liu, Zhuang, Tan, Weihong
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Aptamers, Nucleotide - antagonists & inhibitors Aptamers, Nucleotide - immunology Azides - chemistry Azides - pharmacology B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - immunology Cell Line, Tumor Cyclooctanes - chemistry Cyclooctanes - pharmacology Humans Immune Checkpoint Inhibitors - chemistry Immune Checkpoint Inhibitors - pharmacology Immunotherapy Mice
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!