Tandem Acceptorless Dehydrogenative Coupling–Decyanation under Nickel Catalysis
The development of new catalytic processes based on abundantly available starting materials by cheap metals is always a fascinating task and marks an important transition in the chemical industry. Herein, a nickel-catalyzed acceptorless dehydrogenative coupling of alcohols with nitriles followed by...
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| Veröffentlicht in: | Journal of organic chemistry 2021-06, Vol.86 (11), p.7552-7562 |
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| container_issue | 11 |
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| container_title | Journal of organic chemistry |
| container_volume | 86 |
| creator | Midya, Siba P Subaramanian, Murugan Babu, Reshma Yadav, Vinita Balaraman, Ekambaram |
| description | The development of new catalytic processes based on abundantly available starting materials by cheap metals is always a fascinating task and marks an important transition in the chemical industry. Herein, a nickel-catalyzed acceptorless dehydrogenative coupling of alcohols with nitriles followed by decyanation of nitriles to access diversely substituted olefins is reported. This unprecedented CC bond-forming methodology takes place in a tandem manner with the formation of formamide as a sole byproduct. The significant advantages of this strategy are the low-cost nickel catalyst, good functional group compatibility (ether, thioether, halo, cyano, ester, amino, N/O/S heterocycles; 43 examples), synthetic convenience, and high reaction selectivity and efficiency. |
| doi_str_mv | 10.1021/acs.joc.1c00592 |
| format | Article |
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| language | eng |
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| source | ACS Publications |
| title | Tandem Acceptorless Dehydrogenative Coupling–Decyanation under Nickel Catalysis |
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