Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping
Background Quantitative susceptibility mapping (QSM) has been used to study the magnetic susceptibility properties of collagen fibers in articular cartilage; however, it is unclear whether QSM is sensitive to changes due to degradation caused by long‐distance running. It is clinically important to u...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2021-11, Vol.54 (5), p.1585-1593 |
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| container_title | Journal of magnetic resonance imaging |
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| creator | Zhang, Ming Li, Yufei Feng, Ruimin Wang, Zhongzheng Wang, Wenjin Zheng, Nan Wang, Shaobai Yan, Fuhua Lu, Yong Tsai, Tsung‐Yuan Wei, Hongjiang |
| description | Background
Quantitative susceptibility mapping (QSM) has been used to study the magnetic susceptibility properties of collagen fibers in articular cartilage; however, it is unclear whether QSM is sensitive to changes due to degradation caused by long‐distance running. It is clinically important to understand the link between long‐distance running and microstructural changes in knee cartilage.
Purpose
To investigate the ability of QSM to assess microstructural changes within cartilage after repetitive loading.
Study Type
Prospective.
Population
Thirteen recreational, male long‐distance runners.
Field Strength/Sequence
Three‐dimensional gradient recalled echo acquired at 3 T.
Assessment
Magnetic resonance imaging (MRI) and 3D kinematics (translations and rotations during treadmill walking and running) of the knee joint were collected before and after marathon running. The compartments for analysis included the patella, trochlea, and subregions of femoral and tibial cartilage. Changes in regional susceptibility and cartilage thickness were calculated after marathon running. A susceptibility profile was obtained by fitting susceptibility as a function of the normalized depth of cartilage from the superficial to deep layers.
Statistical Tests
Paired t‐test or Wilcoxon signed‐rank test, 95% confidence interval (CI) of the depth‐wise susceptibility profile, Pearson correlation or Spearman correlation.
Results
There was a statistically significant increase in susceptibility value in the weight‐bearing region of central medial femoral cartilage (cMF‐c) after marathon running (pre‐marathon: −0.0219 ± 0.0151 ppm, post‐marathon: −0.0070 ± 0.0213 ppm, P |
| doi_str_mv | 10.1002/jmri.27745 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2532246325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2581129881</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3345-ef5f3d96e094f05dc4772f0cd456921b72fbd4b79e9a2e83a1e158bc0d5ac7e53</originalsourceid><addsrcrecordid>eNp90UtLw0AQB_AgCtbqxU8Q8CJC6j7zOErwUW0Rq_UaNsmk3ZJu4u5GKX55N8ZTD552h_3tMMPf884xmmCEyPVmq-WERBHjB94Ic0ICwuPw0N0RpwGOUXTsnRizQQglCeMj7ztdC7UCXyr_tTMFtFbmspZ257-LugPTPzwpAD8V2spaOHpTWdD-XGhh143yF51SUq38OQjTaSj9penLl04oK62w8hP2W89F2zpz6h1VojZw9neOveXd7Vv6EMye76fpzSwoKGU8gIpXtExCQAmrEC8LFkWkQkXJeJgQnLsiL1keJZAIAjEVGDCP8wKVXBQRcDr2Loe-rW4-3E4220o3T10LBU1nMsIpISykpKcXe3TTdFq56ZyKMSZJHGOnrgZV6MYYDVXWarkVepdhlPU5ZH0O2W8ODuMBf8kadv_I7HG-mA5_fgDM6YyZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2581129881</pqid></control><display><type>article</type><title>Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhang, Ming ; Li, Yufei ; Feng, Ruimin ; Wang, Zhongzheng ; Wang, Wenjin ; Zheng, Nan ; Wang, Shaobai ; Yan, Fuhua ; Lu, Yong ; Tsai, Tsung‐Yuan ; Wei, Hongjiang</creator><creatorcontrib>Zhang, Ming ; Li, Yufei ; Feng, Ruimin ; Wang, Zhongzheng ; Wang, Wenjin ; Zheng, Nan ; Wang, Shaobai ; Yan, Fuhua ; Lu, Yong ; Tsai, Tsung‐Yuan ; Wei, Hongjiang</creatorcontrib><description>Background
Quantitative susceptibility mapping (QSM) has been used to study the magnetic susceptibility properties of collagen fibers in articular cartilage; however, it is unclear whether QSM is sensitive to changes due to degradation caused by long‐distance running. It is clinically important to understand the link between long‐distance running and microstructural changes in knee cartilage.
Purpose
To investigate the ability of QSM to assess microstructural changes within cartilage after repetitive loading.
Study Type
Prospective.
Population
Thirteen recreational, male long‐distance runners.
Field Strength/Sequence
Three‐dimensional gradient recalled echo acquired at 3 T.
Assessment
Magnetic resonance imaging (MRI) and 3D kinematics (translations and rotations during treadmill walking and running) of the knee joint were collected before and after marathon running. The compartments for analysis included the patella, trochlea, and subregions of femoral and tibial cartilage. Changes in regional susceptibility and cartilage thickness were calculated after marathon running. A susceptibility profile was obtained by fitting susceptibility as a function of the normalized depth of cartilage from the superficial to deep layers.
Statistical Tests
Paired t‐test or Wilcoxon signed‐rank test, 95% confidence interval (CI) of the depth‐wise susceptibility profile, Pearson correlation or Spearman correlation.
Results
There was a statistically significant increase in susceptibility value in the weight‐bearing region of central medial femoral cartilage (cMF‐c) after marathon running (pre‐marathon: −0.0219 ± 0.0151 ppm, post‐marathon: −0.0070 ± 0.0213 ppm, P < 0.05), while the cartilage thickness did not show significant changes in any regions (P‐value range: 0.068–0.963). Significant susceptibility elevations occurred in the middle and deep layers of cMF‐c (95% CIs did not overlap). A trend toward a positive correlation was found between the changes in susceptibility value in cMF‐c and proximal–distal translation of the knee joint during walking (r = 0.55, P = 0.101) and running (r = 0.57, P = 0.089).
Data Conclusion
Localized magnetic susceptibility alterations were observed within knee cartilage in the weight‐bearing area after repetitive loading without any morphologic changes.
Level of Evidence
2
Technical Efficacy
Stage 2</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.27745</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>articular cartilage ; Cartilage ; Cartilage (articular) ; Collagen (type I) ; collagen fiber ; Confidence intervals ; Correlation ; degradation ; Femur ; Fibers ; Field strength ; Joints (anatomy) ; Kinematics ; Knee ; Magnetic permeability ; Magnetic properties ; Magnetic resonance imaging ; Magnetic susceptibility ; Mapping ; marathon ; Marathons ; Population studies ; quantitative susceptibility mapping ; Rank tests ; Repeated loading ; Running ; Statistical analysis ; Statistical tests ; Susceptibility ; Thickness ; Translations ; Treadmills ; Walking ; Weight</subject><ispartof>Journal of magnetic resonance imaging, 2021-11, Vol.54 (5), p.1585-1593</ispartof><rights>2021 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3345-ef5f3d96e094f05dc4772f0cd456921b72fbd4b79e9a2e83a1e158bc0d5ac7e53</citedby><cites>FETCH-LOGICAL-c3345-ef5f3d96e094f05dc4772f0cd456921b72fbd4b79e9a2e83a1e158bc0d5ac7e53</cites><orcidid>0000-0002-9060-4152 ; 0000-0001-8260-0437</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.27745$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.27745$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Zhang, Ming</creatorcontrib><creatorcontrib>Li, Yufei</creatorcontrib><creatorcontrib>Feng, Ruimin</creatorcontrib><creatorcontrib>Wang, Zhongzheng</creatorcontrib><creatorcontrib>Wang, Wenjin</creatorcontrib><creatorcontrib>Zheng, Nan</creatorcontrib><creatorcontrib>Wang, Shaobai</creatorcontrib><creatorcontrib>Yan, Fuhua</creatorcontrib><creatorcontrib>Lu, Yong</creatorcontrib><creatorcontrib>Tsai, Tsung‐Yuan</creatorcontrib><creatorcontrib>Wei, Hongjiang</creatorcontrib><title>Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping</title><title>Journal of magnetic resonance imaging</title><description>Background
Quantitative susceptibility mapping (QSM) has been used to study the magnetic susceptibility properties of collagen fibers in articular cartilage; however, it is unclear whether QSM is sensitive to changes due to degradation caused by long‐distance running. It is clinically important to understand the link between long‐distance running and microstructural changes in knee cartilage.
Purpose
To investigate the ability of QSM to assess microstructural changes within cartilage after repetitive loading.
Study Type
Prospective.
Population
Thirteen recreational, male long‐distance runners.
Field Strength/Sequence
Three‐dimensional gradient recalled echo acquired at 3 T.
Assessment
Magnetic resonance imaging (MRI) and 3D kinematics (translations and rotations during treadmill walking and running) of the knee joint were collected before and after marathon running. The compartments for analysis included the patella, trochlea, and subregions of femoral and tibial cartilage. Changes in regional susceptibility and cartilage thickness were calculated after marathon running. A susceptibility profile was obtained by fitting susceptibility as a function of the normalized depth of cartilage from the superficial to deep layers.
Statistical Tests
Paired t‐test or Wilcoxon signed‐rank test, 95% confidence interval (CI) of the depth‐wise susceptibility profile, Pearson correlation or Spearman correlation.
Results
There was a statistically significant increase in susceptibility value in the weight‐bearing region of central medial femoral cartilage (cMF‐c) after marathon running (pre‐marathon: −0.0219 ± 0.0151 ppm, post‐marathon: −0.0070 ± 0.0213 ppm, P < 0.05), while the cartilage thickness did not show significant changes in any regions (P‐value range: 0.068–0.963). Significant susceptibility elevations occurred in the middle and deep layers of cMF‐c (95% CIs did not overlap). A trend toward a positive correlation was found between the changes in susceptibility value in cMF‐c and proximal–distal translation of the knee joint during walking (r = 0.55, P = 0.101) and running (r = 0.57, P = 0.089).
Data Conclusion
Localized magnetic susceptibility alterations were observed within knee cartilage in the weight‐bearing area after repetitive loading without any morphologic changes.
Level of Evidence
2
Technical Efficacy
Stage 2</description><subject>articular cartilage</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Collagen (type I)</subject><subject>collagen fiber</subject><subject>Confidence intervals</subject><subject>Correlation</subject><subject>degradation</subject><subject>Femur</subject><subject>Fibers</subject><subject>Field strength</subject><subject>Joints (anatomy)</subject><subject>Kinematics</subject><subject>Knee</subject><subject>Magnetic permeability</subject><subject>Magnetic properties</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic susceptibility</subject><subject>Mapping</subject><subject>marathon</subject><subject>Marathons</subject><subject>Population studies</subject><subject>quantitative susceptibility mapping</subject><subject>Rank tests</subject><subject>Repeated loading</subject><subject>Running</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Susceptibility</subject><subject>Thickness</subject><subject>Translations</subject><subject>Treadmills</subject><subject>Walking</subject><subject>Weight</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp90UtLw0AQB_AgCtbqxU8Q8CJC6j7zOErwUW0Rq_UaNsmk3ZJu4u5GKX55N8ZTD552h_3tMMPf884xmmCEyPVmq-WERBHjB94Ic0ICwuPw0N0RpwGOUXTsnRizQQglCeMj7ztdC7UCXyr_tTMFtFbmspZ257-LugPTPzwpAD8V2spaOHpTWdD-XGhh143yF51SUq38OQjTaSj9penLl04oK62w8hP2W89F2zpz6h1VojZw9neOveXd7Vv6EMye76fpzSwoKGU8gIpXtExCQAmrEC8LFkWkQkXJeJgQnLsiL1keJZAIAjEVGDCP8wKVXBQRcDr2Loe-rW4-3E4220o3T10LBU1nMsIpISykpKcXe3TTdFq56ZyKMSZJHGOnrgZV6MYYDVXWarkVepdhlPU5ZH0O2W8ODuMBf8kadv_I7HG-mA5_fgDM6YyZ</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Zhang, Ming</creator><creator>Li, Yufei</creator><creator>Feng, Ruimin</creator><creator>Wang, Zhongzheng</creator><creator>Wang, Wenjin</creator><creator>Zheng, Nan</creator><creator>Wang, Shaobai</creator><creator>Yan, Fuhua</creator><creator>Lu, Yong</creator><creator>Tsai, Tsung‐Yuan</creator><creator>Wei, Hongjiang</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9060-4152</orcidid><orcidid>https://orcid.org/0000-0001-8260-0437</orcidid></search><sort><creationdate>202111</creationdate><title>Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping</title><author>Zhang, Ming ; Li, Yufei ; Feng, Ruimin ; Wang, Zhongzheng ; Wang, Wenjin ; Zheng, Nan ; Wang, Shaobai ; Yan, Fuhua ; Lu, Yong ; Tsai, Tsung‐Yuan ; Wei, Hongjiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3345-ef5f3d96e094f05dc4772f0cd456921b72fbd4b79e9a2e83a1e158bc0d5ac7e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>articular cartilage</topic><topic>Cartilage</topic><topic>Cartilage (articular)</topic><topic>Collagen (type I)</topic><topic>collagen fiber</topic><topic>Confidence intervals</topic><topic>Correlation</topic><topic>degradation</topic><topic>Femur</topic><topic>Fibers</topic><topic>Field strength</topic><topic>Joints (anatomy)</topic><topic>Kinematics</topic><topic>Knee</topic><topic>Magnetic permeability</topic><topic>Magnetic properties</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic susceptibility</topic><topic>Mapping</topic><topic>marathon</topic><topic>Marathons</topic><topic>Population studies</topic><topic>quantitative susceptibility mapping</topic><topic>Rank tests</topic><topic>Repeated loading</topic><topic>Running</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Susceptibility</topic><topic>Thickness</topic><topic>Translations</topic><topic>Treadmills</topic><topic>Walking</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ming</creatorcontrib><creatorcontrib>Li, Yufei</creatorcontrib><creatorcontrib>Feng, Ruimin</creatorcontrib><creatorcontrib>Wang, Zhongzheng</creatorcontrib><creatorcontrib>Wang, Wenjin</creatorcontrib><creatorcontrib>Zheng, Nan</creatorcontrib><creatorcontrib>Wang, Shaobai</creatorcontrib><creatorcontrib>Yan, Fuhua</creatorcontrib><creatorcontrib>Lu, Yong</creatorcontrib><creatorcontrib>Tsai, Tsung‐Yuan</creatorcontrib><creatorcontrib>Wei, Hongjiang</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ming</au><au>Li, Yufei</au><au>Feng, Ruimin</au><au>Wang, Zhongzheng</au><au>Wang, Wenjin</au><au>Zheng, Nan</au><au>Wang, Shaobai</au><au>Yan, Fuhua</au><au>Lu, Yong</au><au>Tsai, Tsung‐Yuan</au><au>Wei, Hongjiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><date>2021-11</date><risdate>2021</risdate><volume>54</volume><issue>5</issue><spage>1585</spage><epage>1593</epage><pages>1585-1593</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Background
Quantitative susceptibility mapping (QSM) has been used to study the magnetic susceptibility properties of collagen fibers in articular cartilage; however, it is unclear whether QSM is sensitive to changes due to degradation caused by long‐distance running. It is clinically important to understand the link between long‐distance running and microstructural changes in knee cartilage.
Purpose
To investigate the ability of QSM to assess microstructural changes within cartilage after repetitive loading.
Study Type
Prospective.
Population
Thirteen recreational, male long‐distance runners.
Field Strength/Sequence
Three‐dimensional gradient recalled echo acquired at 3 T.
Assessment
Magnetic resonance imaging (MRI) and 3D kinematics (translations and rotations during treadmill walking and running) of the knee joint were collected before and after marathon running. The compartments for analysis included the patella, trochlea, and subregions of femoral and tibial cartilage. Changes in regional susceptibility and cartilage thickness were calculated after marathon running. A susceptibility profile was obtained by fitting susceptibility as a function of the normalized depth of cartilage from the superficial to deep layers.
Statistical Tests
Paired t‐test or Wilcoxon signed‐rank test, 95% confidence interval (CI) of the depth‐wise susceptibility profile, Pearson correlation or Spearman correlation.
Results
There was a statistically significant increase in susceptibility value in the weight‐bearing region of central medial femoral cartilage (cMF‐c) after marathon running (pre‐marathon: −0.0219 ± 0.0151 ppm, post‐marathon: −0.0070 ± 0.0213 ppm, P < 0.05), while the cartilage thickness did not show significant changes in any regions (P‐value range: 0.068–0.963). Significant susceptibility elevations occurred in the middle and deep layers of cMF‐c (95% CIs did not overlap). A trend toward a positive correlation was found between the changes in susceptibility value in cMF‐c and proximal–distal translation of the knee joint during walking (r = 0.55, P = 0.101) and running (r = 0.57, P = 0.089).
Data Conclusion
Localized magnetic susceptibility alterations were observed within knee cartilage in the weight‐bearing area after repetitive loading without any morphologic changes.
Level of Evidence
2
Technical Efficacy
Stage 2</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/jmri.27745</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9060-4152</orcidid><orcidid>https://orcid.org/0000-0001-8260-0437</orcidid></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2021-11, Vol.54 (5), p.1585-1593 |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | articular cartilage Cartilage Cartilage (articular) Collagen (type I) collagen fiber Confidence intervals Correlation degradation Femur Fibers Field strength Joints (anatomy) Kinematics Knee Magnetic permeability Magnetic properties Magnetic resonance imaging Magnetic susceptibility Mapping marathon Marathons Population studies quantitative susceptibility mapping Rank tests Repeated loading Running Statistical analysis Statistical tests Susceptibility Thickness Translations Treadmills Walking Weight |
| title | Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping |
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