Lipoprotein (a), hypertension, and cardiovascular outcomes: a prospective study of patients with stable coronary artery disease
Although emerging data suggest that circulating lipoprotein (a) [Lp (a)] could predict cardiovascular events (CVEs) in patients with cardiovascular disease, no study is currently available regarding the prognostic linkage of Lp (a) and hypertension in patients with coronary artery disease (CAD). Thi...
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| Veröffentlicht in: | Hypertension research 2021-09, Vol.44 (9), p.1158-1167 |
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| container_title | Hypertension research |
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| creator | Liu, Hui-Hui Cao, Ye-Xuan Jin, Jing-Lu Hua, Qi Li, Yan-Fang Guo, Yuan-Lin Zhu, Cheng-Gang Wu, Na-Qiong Dong, Qian Li, Jian-Jun |
| description | Although emerging data suggest that circulating lipoprotein (a) [Lp (a)] could predict cardiovascular events (CVEs) in patients with cardiovascular disease, no study is currently available regarding the prognostic linkage of Lp (a) and hypertension in patients with coronary artery disease (CAD). This study sought to evaluate the association of Lp (a), hypertension and cardiovascular outcomes in patients with stable CAD. A total of 8668 patients with stable CAD were consecutively enrolled. Baseline Lp (a) concentrations were measured. All subjects were categorized according to Lp (a) levels of |
| doi_str_mv | 10.1038/s41440-021-00668-4 |
| format | Article |
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This study sought to evaluate the association of Lp (a), hypertension and cardiovascular outcomes in patients with stable CAD. A total of 8668 patients with stable CAD were consecutively enrolled. Baseline Lp (a) concentrations were measured. All subjects were categorized according to Lp (a) levels of <10 (low), 10-30 (medium) and ≥30 mg/dL (high) and were further stratified by hypertension status. They were regularly followed-up for the occurrence of cardiovascular death, nonfatal myocardial infarction, and stroke. Over an average of 54.81 ± 18.60 months of follow-up, 584 (6.7%) CVEs occurred. Kaplan-Meier and multivariate Cox regression analyses showed that elevated Lp (a) levels had a significant association with CVEs in hypertensive patients, regardless of the control status of blood pressure, but not in normotensive subjects. Moreover, when analyzed by subgroups according to both Lp (a) category and hypertension status, the risk of CVEs was only significantly elevated in the high Lp (a) plus hypertension group compared with the reference group with low Lp (a) levels and normotension (hazard ratio: 1.80, 95% confidence interval: 1.11-2.91). Elevated Lp (a) was associated with an increased risk of CVEs in stable CAD patients with hypertension. Moreover, the coexistence of high Lp (a) concentrations and hypertension greatly worsened the clinical prognosis in patients with CAD, which may suggest a prognostic correlation between Lp (a) and hypertension.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-021-00668-4</identifier><identifier>PMID: 34035483</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Biomarkers ; Cardiovascular disease ; Clinical outcomes ; Coronary Artery Disease ; Coronary vessels ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - epidemiology ; Lipids ; Lipoprotein(a) ; Myocardial Infarction ; Prospective Studies ; Proteins ; Risk Factors</subject><ispartof>Hypertension research, 2021-09, Vol.44 (9), p.1158-1167</ispartof><rights>2021. The Author(s), under exclusive licence to The Japanese Society of Hypertension.</rights><rights>The Author(s), under exclusive licence to The Japanese Society of Hypertension 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-a4c777b4fa19ede1ee83f2a277de730f80e86dcf0673555a1d615c2e5600962e3</citedby><cites>FETCH-LOGICAL-c355t-a4c777b4fa19ede1ee83f2a277de730f80e86dcf0673555a1d615c2e5600962e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34035483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Hui-Hui</creatorcontrib><creatorcontrib>Cao, Ye-Xuan</creatorcontrib><creatorcontrib>Jin, Jing-Lu</creatorcontrib><creatorcontrib>Hua, Qi</creatorcontrib><creatorcontrib>Li, Yan-Fang</creatorcontrib><creatorcontrib>Guo, Yuan-Lin</creatorcontrib><creatorcontrib>Zhu, Cheng-Gang</creatorcontrib><creatorcontrib>Wu, Na-Qiong</creatorcontrib><creatorcontrib>Dong, Qian</creatorcontrib><creatorcontrib>Li, Jian-Jun</creatorcontrib><title>Lipoprotein (a), hypertension, and cardiovascular outcomes: a prospective study of patients with stable coronary artery disease</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>Although emerging data suggest that circulating lipoprotein (a) [Lp (a)] could predict cardiovascular events (CVEs) in patients with cardiovascular disease, no study is currently available regarding the prognostic linkage of Lp (a) and hypertension in patients with coronary artery disease (CAD). This study sought to evaluate the association of Lp (a), hypertension and cardiovascular outcomes in patients with stable CAD. A total of 8668 patients with stable CAD were consecutively enrolled. Baseline Lp (a) concentrations were measured. All subjects were categorized according to Lp (a) levels of <10 (low), 10-30 (medium) and ≥30 mg/dL (high) and were further stratified by hypertension status. They were regularly followed-up for the occurrence of cardiovascular death, nonfatal myocardial infarction, and stroke. Over an average of 54.81 ± 18.60 months of follow-up, 584 (6.7%) CVEs occurred. Kaplan-Meier and multivariate Cox regression analyses showed that elevated Lp (a) levels had a significant association with CVEs in hypertensive patients, regardless of the control status of blood pressure, but not in normotensive subjects. Moreover, when analyzed by subgroups according to both Lp (a) category and hypertension status, the risk of CVEs was only significantly elevated in the high Lp (a) plus hypertension group compared with the reference group with low Lp (a) levels and normotension (hazard ratio: 1.80, 95% confidence interval: 1.11-2.91). Elevated Lp (a) was associated with an increased risk of CVEs in stable CAD patients with hypertension. Moreover, the coexistence of high Lp (a) concentrations and hypertension greatly worsened the clinical prognosis in patients with CAD, which may suggest a prognostic correlation between Lp (a) and hypertension.</description><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Clinical outcomes</subject><subject>Coronary Artery Disease</subject><subject>Coronary vessels</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - epidemiology</subject><subject>Lipids</subject><subject>Lipoprotein(a)</subject><subject>Myocardial Infarction</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Risk Factors</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkU1LHTEUhkNR6vXjD3RRAm4sODbfM-NOpLaFC27sOpybnMHI3Mk0yVjuyr9u2mu76OqE8LwvJ3kI-cDZFWey-5wVV4o1TPCGMWO6Rr0jKy5VPQiuDsiK9dw0vZHmiBzn_MSY6HTP35MjqZjUqpMr8rIOc5xTLBgmegGfLunjbsZUcMohTpcUJk8dJB_iM2S3jJBoXIqLW8zXFGhN5hldCc9Ic1n8jsaBzlACTiXTX6E81mvYjEhdTHGCtKNQy-vwISNkPCWHA4wZz97mCflx9-Xh9luzvv_6_fZm3TipdWlAubZtN2oA3qNHjtjJQYBoW4-tZEPHsDPeDcy0ldfAveHaCdSGsd4IlCfkYt9bN_65YC52G7LDcYQJ45Kt0FIIxbUWFT3_D32KS5rqdpUyvWj73nSVEnvK1S_ICQc7p7CtD7Sc2d967F6PrXrsHz1W1dDHt-pls0X_L_LXh3wFlkeMig</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Liu, Hui-Hui</creator><creator>Cao, Ye-Xuan</creator><creator>Jin, Jing-Lu</creator><creator>Hua, Qi</creator><creator>Li, Yan-Fang</creator><creator>Guo, Yuan-Lin</creator><creator>Zhu, Cheng-Gang</creator><creator>Wu, Na-Qiong</creator><creator>Dong, Qian</creator><creator>Li, Jian-Jun</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210901</creationdate><title>Lipoprotein (a), hypertension, and cardiovascular outcomes: a prospective study of patients with stable coronary artery disease</title><author>Liu, Hui-Hui ; Cao, Ye-Xuan ; Jin, Jing-Lu ; Hua, Qi ; Li, Yan-Fang ; Guo, Yuan-Lin ; Zhu, Cheng-Gang ; Wu, Na-Qiong ; Dong, Qian ; Li, Jian-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-a4c777b4fa19ede1ee83f2a277de730f80e86dcf0673555a1d615c2e5600962e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Clinical outcomes</topic><topic>Coronary Artery Disease</topic><topic>Coronary vessels</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - epidemiology</topic><topic>Lipids</topic><topic>Lipoprotein(a)</topic><topic>Myocardial Infarction</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Hui-Hui</creatorcontrib><creatorcontrib>Cao, Ye-Xuan</creatorcontrib><creatorcontrib>Jin, Jing-Lu</creatorcontrib><creatorcontrib>Hua, Qi</creatorcontrib><creatorcontrib>Li, Yan-Fang</creatorcontrib><creatorcontrib>Guo, Yuan-Lin</creatorcontrib><creatorcontrib>Zhu, Cheng-Gang</creatorcontrib><creatorcontrib>Wu, Na-Qiong</creatorcontrib><creatorcontrib>Dong, Qian</creatorcontrib><creatorcontrib>Li, Jian-Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Hui-Hui</au><au>Cao, Ye-Xuan</au><au>Jin, Jing-Lu</au><au>Hua, Qi</au><au>Li, Yan-Fang</au><au>Guo, Yuan-Lin</au><au>Zhu, Cheng-Gang</au><au>Wu, Na-Qiong</au><au>Dong, Qian</au><au>Li, Jian-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein (a), hypertension, and cardiovascular outcomes: a prospective study of patients with stable coronary artery disease</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>44</volume><issue>9</issue><spage>1158</spage><epage>1167</epage><pages>1158-1167</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Although emerging data suggest that circulating lipoprotein (a) [Lp (a)] could predict cardiovascular events (CVEs) in patients with cardiovascular disease, no study is currently available regarding the prognostic linkage of Lp (a) and hypertension in patients with coronary artery disease (CAD). This study sought to evaluate the association of Lp (a), hypertension and cardiovascular outcomes in patients with stable CAD. A total of 8668 patients with stable CAD were consecutively enrolled. Baseline Lp (a) concentrations were measured. All subjects were categorized according to Lp (a) levels of <10 (low), 10-30 (medium) and ≥30 mg/dL (high) and were further stratified by hypertension status. They were regularly followed-up for the occurrence of cardiovascular death, nonfatal myocardial infarction, and stroke. Over an average of 54.81 ± 18.60 months of follow-up, 584 (6.7%) CVEs occurred. Kaplan-Meier and multivariate Cox regression analyses showed that elevated Lp (a) levels had a significant association with CVEs in hypertensive patients, regardless of the control status of blood pressure, but not in normotensive subjects. Moreover, when analyzed by subgroups according to both Lp (a) category and hypertension status, the risk of CVEs was only significantly elevated in the high Lp (a) plus hypertension group compared with the reference group with low Lp (a) levels and normotension (hazard ratio: 1.80, 95% confidence interval: 1.11-2.91). Elevated Lp (a) was associated with an increased risk of CVEs in stable CAD patients with hypertension. Moreover, the coexistence of high Lp (a) concentrations and hypertension greatly worsened the clinical prognosis in patients with CAD, which may suggest a prognostic correlation between Lp (a) and hypertension.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>34035483</pmid><doi>10.1038/s41440-021-00668-4</doi><tpages>10</tpages></addata></record> |
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| subjects | Biomarkers Cardiovascular disease Clinical outcomes Coronary Artery Disease Coronary vessels Humans Hypertension Hypertension - complications Hypertension - epidemiology Lipids Lipoprotein(a) Myocardial Infarction Prospective Studies Proteins Risk Factors |
| title | Lipoprotein (a), hypertension, and cardiovascular outcomes: a prospective study of patients with stable coronary artery disease |
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