N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors

[Display omitted] The RSK2 kinase is the downstream effector of the Ras/Raf/MEK/ERK pathway, that is often aberrantly activated in acute myeloid leukemia (AML). Recently, we reported a structure-activity study for BI-D1870, the pan-RSK inhibitor, and identified pteridinones that inhibited cellular R...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2021-07, Vol.41, p.116220-116220, Article 116220
Hauptverfasser:	Casalvieri, Kimberly A., Matheson, Christopher J., Warfield, Becka M., Backos, Donald S., Reigan, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Inhibitor Kinase RSK Structure-activity relationship
Online-Zugang:	Volltext
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