Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis
Objective To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals...
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| Veröffentlicht in: | Journal of perinatology 2021-07, Vol.41 (7), p.1755-1759 |
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| container_title | Journal of perinatology |
| container_volume | 41 |
| creator | Dekonenko, Charlene Fraser, Jason D. Deans, Katherine J. Fallat, Mary E. Helmrath, Michael Kabre, Rashmi Leys, Charles M. Burns, R. Cartland Corkumd, Kristine Dillon, Patrick A. Downard, Cynthia Wright, Tiffany N. Gadepalli, Samir K. Grabowski, Julia E. Hernandez, Edward Hirschl, Ronald Johnson, Kevin N. Kohler, Jonathan E. Landman, Matthew P. Landisch, Rachel M. Lawrence, Amy E. Mak, Grace Z. Minneci, Peter C. Rymeski, Beth Sato, Thomas T. Slater, Bethany J. St. Peter, Shawn D. |
| description | Objective
To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling.
Study design
A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported.
Result
There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%).
Conclusion
This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes. |
| doi_str_mv | 10.1038/s41372-021-01093-8 |
| format | Article |
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To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling.
Study design
A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported.
Result
There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%).
Conclusion
This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-021-01093-8</identifier><identifier>PMID: 34035447</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/409 ; 692/699/1503/1581 ; Abdomen ; Antibiotics ; Care and treatment ; Counseling ; Demographics ; Diseases ; Estimates ; Families & family life ; Gastroschisis ; Gastroschisis - epidemiology ; Hospitals ; Hospitals, Pediatric ; Humans ; Infant, Newborn ; Infants (Newborn) ; Length of Stay ; Medicine ; Medicine & Public Health ; Mortality ; Motivation ; Neonates ; Patient outcomes ; Patients ; Pediatric research ; Pediatric Surgery ; Pediatrics ; Retrospective Studies ; Statistics, Nonparametric ; Surgery ; Surgical outcomes ; Treatment Outcome ; Ventilators</subject><ispartof>Journal of perinatology, 2021-07, Vol.41 (7), p.1755-1759</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-e2b43efd8239512c57d32b3f049cabc3407b2460c21db9f9592d0532a5c4ecf93</citedby><cites>FETCH-LOGICAL-c473t-e2b43efd8239512c57d32b3f049cabc3407b2460c21db9f9592d0532a5c4ecf93</cites><orcidid>0000-0002-6140-9016 ; 0000-0001-8268-8723 ; 0000-0002-5498-9980 ; 0000-0003-0203-2711</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-021-01093-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-021-01093-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34035447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dekonenko, Charlene</creatorcontrib><creatorcontrib>Fraser, Jason D.</creatorcontrib><creatorcontrib>Deans, Katherine J.</creatorcontrib><creatorcontrib>Fallat, Mary E.</creatorcontrib><creatorcontrib>Helmrath, Michael</creatorcontrib><creatorcontrib>Kabre, Rashmi</creatorcontrib><creatorcontrib>Leys, Charles M.</creatorcontrib><creatorcontrib>Burns, R. Cartland</creatorcontrib><creatorcontrib>Corkumd, Kristine</creatorcontrib><creatorcontrib>Dillon, Patrick A.</creatorcontrib><creatorcontrib>Downard, Cynthia</creatorcontrib><creatorcontrib>Wright, Tiffany N.</creatorcontrib><creatorcontrib>Gadepalli, Samir K.</creatorcontrib><creatorcontrib>Grabowski, Julia E.</creatorcontrib><creatorcontrib>Hernandez, Edward</creatorcontrib><creatorcontrib>Hirschl, Ronald</creatorcontrib><creatorcontrib>Johnson, Kevin N.</creatorcontrib><creatorcontrib>Kohler, Jonathan E.</creatorcontrib><creatorcontrib>Landman, Matthew P.</creatorcontrib><creatorcontrib>Landisch, Rachel M.</creatorcontrib><creatorcontrib>Lawrence, Amy E.</creatorcontrib><creatorcontrib>Mak, Grace Z.</creatorcontrib><creatorcontrib>Minneci, Peter C.</creatorcontrib><creatorcontrib>Rymeski, Beth</creatorcontrib><creatorcontrib>Sato, Thomas T.</creatorcontrib><creatorcontrib>Slater, Bethany J.</creatorcontrib><creatorcontrib>St. Peter, Shawn D.</creatorcontrib><title>Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling.
Study design
A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported.
Result
There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%).
Conclusion
This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.</description><subject>692/308/409</subject><subject>692/699/1503/1581</subject><subject>Abdomen</subject><subject>Antibiotics</subject><subject>Care and treatment</subject><subject>Counseling</subject><subject>Demographics</subject><subject>Diseases</subject><subject>Estimates</subject><subject>Families & family life</subject><subject>Gastroschisis</subject><subject>Gastroschisis - epidemiology</subject><subject>Hospitals</subject><subject>Hospitals, Pediatric</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants (Newborn)</subject><subject>Length of Stay</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Motivation</subject><subject>Neonates</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pediatric research</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Statistics, Nonparametric</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Treatment Outcome</subject><subject>Ventilators</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk1v1DAQhi0EotvCH-CALCEhLmn9GSfcqgoKUqVeytlynPGuqyQOtlOVf493t6UsQpUPtmaeeTUzfhF6R8kpJbw5S4JyxSrCaEUoaXnVvEArKlRdSSn4S7QiSpQgF_UROk7plpBtUr1GR1wQLoVQK2Svl2zDCAn7Ca9NyjEku_HJp88Y7mew2WQfpl06bwDPIeXJZDPgGaIPPXYh4uTHeQB8l3CRKq_7Q6U36JUzQ4K3D_cJ-vH1y83Ft-rq-vL7xflVZYXiuQLWCQ6ubxhvJWVWqp6zjjsiWms6W3pWHRM1sYz2Xeta2bKeSM6MtAKsa_kJ-rTXnWP4uUDKevTJwjCYCcKSNCswE6StWUE__IPehiVOpbtCSSJUw9vmiVqbAbSfXMjR2K2oPq_rhinC67pQp_-hyulh9DZM4HyJHxR8_KtgA2bImxSGZbfoQ5DtQVt2mSI4PUc_mvhLU6K3FtB7C-hiAb2zgN42_f5htKUbof9T8vjnBeB7IJXUtIb4NPszsr8B0ou6fQ</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Dekonenko, Charlene</creator><creator>Fraser, Jason D.</creator><creator>Deans, Katherine J.</creator><creator>Fallat, Mary E.</creator><creator>Helmrath, Michael</creator><creator>Kabre, Rashmi</creator><creator>Leys, Charles M.</creator><creator>Burns, R. 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Cartland ; Corkumd, Kristine ; Dillon, Patrick A. ; Downard, Cynthia ; Wright, Tiffany N. ; Gadepalli, Samir K. ; Grabowski, Julia E. ; Hernandez, Edward ; Hirschl, Ronald ; Johnson, Kevin N. ; Kohler, Jonathan E. ; Landman, Matthew P. ; Landisch, Rachel M. ; Lawrence, Amy E. ; Mak, Grace Z. ; Minneci, Peter C. ; Rymeski, Beth ; Sato, Thomas T. ; Slater, Bethany J. ; St. Peter, Shawn D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-e2b43efd8239512c57d32b3f049cabc3407b2460c21db9f9592d0532a5c4ecf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/308/409</topic><topic>692/699/1503/1581</topic><topic>Abdomen</topic><topic>Antibiotics</topic><topic>Care and treatment</topic><topic>Counseling</topic><topic>Demographics</topic><topic>Diseases</topic><topic>Estimates</topic><topic>Families & family life</topic><topic>Gastroschisis</topic><topic>Gastroschisis - epidemiology</topic><topic>Hospitals</topic><topic>Hospitals, Pediatric</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants (Newborn)</topic><topic>Length of Stay</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Motivation</topic><topic>Neonates</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Pediatric research</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Statistics, Nonparametric</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Treatment Outcome</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dekonenko, Charlene</creatorcontrib><creatorcontrib>Fraser, Jason D.</creatorcontrib><creatorcontrib>Deans, Katherine J.</creatorcontrib><creatorcontrib>Fallat, Mary E.</creatorcontrib><creatorcontrib>Helmrath, Michael</creatorcontrib><creatorcontrib>Kabre, Rashmi</creatorcontrib><creatorcontrib>Leys, Charles M.</creatorcontrib><creatorcontrib>Burns, R. 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Cartland</au><au>Corkumd, Kristine</au><au>Dillon, Patrick A.</au><au>Downard, Cynthia</au><au>Wright, Tiffany N.</au><au>Gadepalli, Samir K.</au><au>Grabowski, Julia E.</au><au>Hernandez, Edward</au><au>Hirschl, Ronald</au><au>Johnson, Kevin N.</au><au>Kohler, Jonathan E.</au><au>Landman, Matthew P.</au><au>Landisch, Rachel M.</au><au>Lawrence, Amy E.</au><au>Mak, Grace Z.</au><au>Minneci, Peter C.</au><au>Rymeski, Beth</au><au>Sato, Thomas T.</au><au>Slater, Bethany J.</au><au>St. Peter, Shawn D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>41</volume><issue>7</issue><spage>1755</spage><epage>1759</epage><pages>1755-1759</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective
To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling.
Study design
A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported.
Result
There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%).
Conclusion
This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>34035447</pmid><doi>10.1038/s41372-021-01093-8</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6140-9016</orcidid><orcidid>https://orcid.org/0000-0001-8268-8723</orcidid><orcidid>https://orcid.org/0000-0002-5498-9980</orcidid><orcidid>https://orcid.org/0000-0003-0203-2711</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2021-07, Vol.41 (7), p.1755-1759 |
| issn | 0743-8346 1476-5543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2532240962 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 692/308/409 692/699/1503/1581 Abdomen Antibiotics Care and treatment Counseling Demographics Diseases Estimates Families & family life Gastroschisis Gastroschisis - epidemiology Hospitals Hospitals, Pediatric Humans Infant, Newborn Infants (Newborn) Length of Stay Medicine Medicine & Public Health Mortality Motivation Neonates Patient outcomes Patients Pediatric research Pediatric Surgery Pediatrics Retrospective Studies Statistics, Nonparametric Surgery Surgical outcomes Treatment Outcome Ventilators |
| title | Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T05%3A08%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Outcomes%20in%20gastroschisis:%20expectations%20in%20the%20postnatal%20period%20for%20simple%20vs%20complex%20gastroschisis&rft.jtitle=Journal%20of%20perinatology&rft.au=Dekonenko,%20Charlene&rft.date=2021-07-01&rft.volume=41&rft.issue=7&rft.spage=1755&rft.epage=1759&rft.pages=1755-1759&rft.issn=0743-8346&rft.eissn=1476-5543&rft_id=info:doi/10.1038/s41372-021-01093-8&rft_dat=%3Cgale_proqu%3EA668270366%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2550478398&rft_id=info:pmid/34035447&rft_galeid=A668270366&rfr_iscdi=true |