Immediate retrograde amnesia induced by midazolam: A prospective, non‐randomised cohort study
Background Midazolam, a short‐acting benzodiazepine, has sedative, anxiolytic, amnestic and anticonvulsant effects. Given its advantages of rapid onset, short duration and low toxicity, midazolam is optimal for any procedural sedation. Midazolam is known to cause anterograde amnesia; however, the po...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2021-11, Vol.75 (11), p.e14402-n/a |
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| creator | Sohn, Hye‐Min Na, Hyo‐Seok Lim, Dongsik Koung Yi, In Nam, Sun‐Woo Do, Sang‐Hwan Hwang, Jung‐Won |
| description | Background
Midazolam, a short‐acting benzodiazepine, has sedative, anxiolytic, amnestic and anticonvulsant effects. Given its advantages of rapid onset, short duration and low toxicity, midazolam is optimal for any procedural sedation. Midazolam is known to cause anterograde amnesia; however, the possibility of retrograde amnesia has also been raised. This prospective cohort, non‐randomised study evaluated the presence and extent of retrograde amnesia induced by midazolam during caesarean delivery.
Methods
One hundred parturients scheduled for elective caesarean delivery under spinal anaesthesia were enrolled. As soon as giving birth, six picture cards were shown to the patients in 1‐min intervals, and then midazolam (0.1 mg/kg) was given or not according to the patients’ preference. This overall retrograde recall rate of six cards was the primary outcome of our study, which was asked by a blinded investigator.
Results
The overall retrograde card recall rate was lower in the midazolam group compared with the control group (77.0 ± 13.4 vs. 87.7 ± 3.9%, P |
| doi_str_mv | 10.1111/ijcp.14402 |
| format | Article |
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Midazolam, a short‐acting benzodiazepine, has sedative, anxiolytic, amnestic and anticonvulsant effects. Given its advantages of rapid onset, short duration and low toxicity, midazolam is optimal for any procedural sedation. Midazolam is known to cause anterograde amnesia; however, the possibility of retrograde amnesia has also been raised. This prospective cohort, non‐randomised study evaluated the presence and extent of retrograde amnesia induced by midazolam during caesarean delivery.
Methods
One hundred parturients scheduled for elective caesarean delivery under spinal anaesthesia were enrolled. As soon as giving birth, six picture cards were shown to the patients in 1‐min intervals, and then midazolam (0.1 mg/kg) was given or not according to the patients’ preference. This overall retrograde recall rate of six cards was the primary outcome of our study, which was asked by a blinded investigator.
Results
The overall retrograde card recall rate was lower in the midazolam group compared with the control group (77.0 ± 13.4 vs. 87.7 ± 3.9%, P < .001), especially at 1 minute before midazolam administration (58% vs. 88%, P < .001). Decreased memory trend was observed as time progressed towards midazolam administration in the midazolam group (P = .035). More patients answered ‘yes’ to the factitious event in the midazolam group than in the control group (26% vs. 4%, P = .004).
Conclusion
Intravenous midazolam could cause a brief‐period retrograde amnesia in visual and event memory. Moreover, there were more spurious reports of intraoperative factitious events in the midazolam group, implying that episodic memories were also affected by midazolam.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.14402</identifier><language>eng</language><publisher>London: Hindawi Limited</publisher><subject>Amnesia ; Anesthesia ; Anticonvulsants ; Benzodiazepines ; Cesarean section ; Cohort analysis ; Intravenous administration ; Memory ; Midazolam ; retrograde ; Retrograde amnesia ; Toxicity</subject><ispartof>International journal of clinical practice (Esher), 2021-11, Vol.75 (11), p.e14402-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3702-86ae132021a126483e5eca2b8b90f1a745b54a06cf8434187386e11252de5cc3</citedby><cites>FETCH-LOGICAL-c3702-86ae132021a126483e5eca2b8b90f1a745b54a06cf8434187386e11252de5cc3</cites><orcidid>0000-0003-0986-3243</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.14402$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.14402$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Sohn, Hye‐Min</creatorcontrib><creatorcontrib>Na, Hyo‐Seok</creatorcontrib><creatorcontrib>Lim, Dongsik</creatorcontrib><creatorcontrib>Koung Yi, In</creatorcontrib><creatorcontrib>Nam, Sun‐Woo</creatorcontrib><creatorcontrib>Do, Sang‐Hwan</creatorcontrib><creatorcontrib>Hwang, Jung‐Won</creatorcontrib><title>Immediate retrograde amnesia induced by midazolam: A prospective, non‐randomised cohort study</title><title>International journal of clinical practice (Esher)</title><description>Background
Midazolam, a short‐acting benzodiazepine, has sedative, anxiolytic, amnestic and anticonvulsant effects. Given its advantages of rapid onset, short duration and low toxicity, midazolam is optimal for any procedural sedation. Midazolam is known to cause anterograde amnesia; however, the possibility of retrograde amnesia has also been raised. This prospective cohort, non‐randomised study evaluated the presence and extent of retrograde amnesia induced by midazolam during caesarean delivery.
Methods
One hundred parturients scheduled for elective caesarean delivery under spinal anaesthesia were enrolled. As soon as giving birth, six picture cards were shown to the patients in 1‐min intervals, and then midazolam (0.1 mg/kg) was given or not according to the patients’ preference. This overall retrograde recall rate of six cards was the primary outcome of our study, which was asked by a blinded investigator.
Results
The overall retrograde card recall rate was lower in the midazolam group compared with the control group (77.0 ± 13.4 vs. 87.7 ± 3.9%, P < .001), especially at 1 minute before midazolam administration (58% vs. 88%, P < .001). Decreased memory trend was observed as time progressed towards midazolam administration in the midazolam group (P = .035). More patients answered ‘yes’ to the factitious event in the midazolam group than in the control group (26% vs. 4%, P = .004).
Conclusion
Intravenous midazolam could cause a brief‐period retrograde amnesia in visual and event memory. Moreover, there were more spurious reports of intraoperative factitious events in the midazolam group, implying that episodic memories were also affected by midazolam.</description><subject>Amnesia</subject><subject>Anesthesia</subject><subject>Anticonvulsants</subject><subject>Benzodiazepines</subject><subject>Cesarean section</subject><subject>Cohort analysis</subject><subject>Intravenous administration</subject><subject>Memory</subject><subject>Midazolam</subject><subject>retrograde</subject><subject>Retrograde amnesia</subject><subject>Toxicity</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp90LtOwzAUBuAIgQQUFp7AEgtCpPj4krhsqOJShAQDu-U6p-AqiYudgMLEI_CMPAmGMjHgxR4-H_3nz7IDoGNI59Qt7WoMQlC2ke1AKVgOTMBmevNC5ZJy2M52Y1xSyqRUdCfTs6bBypkOScAu-MdgKiSmaTE6Q1xb9RYrMh9I4yrz5mvTnJFzsgo-rtB27gVPSOvbz_ePYNrKNy4mbf2TDx2JXV8Ne9nWwtQR93_vUfZwefEwvc5v765m0_Pb3PKSslwVBoEzysAAK4TiKNEaNlfzCV2AKYWcS2FoYRdKcAGq5KpAACZZhdJaPsqO1mNTsuceY6dTFIt1bVr0fdRMcsYEpXyS6OEfuvR9aFO4pFQaPikLSOp4rWxaNQZc6FVwjQmDBqq_q9bfVeufqhOGNX51NQ7_SD27md6v_3wBLZ-BMg</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Sohn, Hye‐Min</creator><creator>Na, Hyo‐Seok</creator><creator>Lim, Dongsik</creator><creator>Koung Yi, In</creator><creator>Nam, Sun‐Woo</creator><creator>Do, Sang‐Hwan</creator><creator>Hwang, Jung‐Won</creator><general>Hindawi Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0986-3243</orcidid></search><sort><creationdate>202111</creationdate><title>Immediate retrograde amnesia induced by midazolam: A prospective, non‐randomised cohort study</title><author>Sohn, Hye‐Min ; Na, Hyo‐Seok ; Lim, Dongsik ; Koung Yi, In ; Nam, Sun‐Woo ; Do, Sang‐Hwan ; Hwang, Jung‐Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3702-86ae132021a126483e5eca2b8b90f1a745b54a06cf8434187386e11252de5cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amnesia</topic><topic>Anesthesia</topic><topic>Anticonvulsants</topic><topic>Benzodiazepines</topic><topic>Cesarean section</topic><topic>Cohort analysis</topic><topic>Intravenous administration</topic><topic>Memory</topic><topic>Midazolam</topic><topic>retrograde</topic><topic>Retrograde amnesia</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sohn, Hye‐Min</creatorcontrib><creatorcontrib>Na, Hyo‐Seok</creatorcontrib><creatorcontrib>Lim, Dongsik</creatorcontrib><creatorcontrib>Koung Yi, In</creatorcontrib><creatorcontrib>Nam, Sun‐Woo</creatorcontrib><creatorcontrib>Do, Sang‐Hwan</creatorcontrib><creatorcontrib>Hwang, Jung‐Won</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sohn, Hye‐Min</au><au>Na, Hyo‐Seok</au><au>Lim, Dongsik</au><au>Koung Yi, In</au><au>Nam, Sun‐Woo</au><au>Do, Sang‐Hwan</au><au>Hwang, Jung‐Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immediate retrograde amnesia induced by midazolam: A prospective, non‐randomised cohort study</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><date>2021-11</date><risdate>2021</risdate><volume>75</volume><issue>11</issue><spage>e14402</spage><epage>n/a</epage><pages>e14402-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Background
Midazolam, a short‐acting benzodiazepine, has sedative, anxiolytic, amnestic and anticonvulsant effects. Given its advantages of rapid onset, short duration and low toxicity, midazolam is optimal for any procedural sedation. Midazolam is known to cause anterograde amnesia; however, the possibility of retrograde amnesia has also been raised. This prospective cohort, non‐randomised study evaluated the presence and extent of retrograde amnesia induced by midazolam during caesarean delivery.
Methods
One hundred parturients scheduled for elective caesarean delivery under spinal anaesthesia were enrolled. As soon as giving birth, six picture cards were shown to the patients in 1‐min intervals, and then midazolam (0.1 mg/kg) was given or not according to the patients’ preference. This overall retrograde recall rate of six cards was the primary outcome of our study, which was asked by a blinded investigator.
Results
The overall retrograde card recall rate was lower in the midazolam group compared with the control group (77.0 ± 13.4 vs. 87.7 ± 3.9%, P < .001), especially at 1 minute before midazolam administration (58% vs. 88%, P < .001). Decreased memory trend was observed as time progressed towards midazolam administration in the midazolam group (P = .035). More patients answered ‘yes’ to the factitious event in the midazolam group than in the control group (26% vs. 4%, P = .004).
Conclusion
Intravenous midazolam could cause a brief‐period retrograde amnesia in visual and event memory. Moreover, there were more spurious reports of intraoperative factitious events in the midazolam group, implying that episodic memories were also affected by midazolam.</abstract><cop>London</cop><pub>Hindawi Limited</pub><doi>10.1111/ijcp.14402</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0986-3243</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amnesia Anesthesia Anticonvulsants Benzodiazepines Cesarean section Cohort analysis Intravenous administration Memory Midazolam retrograde Retrograde amnesia Toxicity |
| title | Immediate retrograde amnesia induced by midazolam: A prospective, non‐randomised cohort study |
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