The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats
The effect of carvacrol (CAR) on oxidative stress, inflammation, and liver dysfunction induced by lipopolysaccharide (LPS) was explored. The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p.), and 25, 50 or 100 mg/kg CAR (i.p.) before LPS. LPS increased aspartate tra...
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| Veröffentlicht in: | International journal for vitamin and nutrition research 2023-04, Vol.93 (2), p.111-121 |
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| container_title | International journal for vitamin and nutrition research |
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| creator | Mortazavi, Alireza Mohammad Pour Kargar, Hossein Beheshti, Farimah Anaeigoudari, Akbar Vaezi, Gholamhasan Hosseini, Mahmoud |
| description | The effect of carvacrol (CAR) on oxidative stress, inflammation, and liver dysfunction induced by lipopolysaccharide (LPS) was explored. The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p.), and 25, 50 or 100 mg/kg CAR (i.p.) before LPS. LPS increased aspartate transaminase (AST: 162±13 U/L), alanine aminotransferase (ALT: 74.6±2.15 U/L), alkaline phosphatase (ALK-P: 811±51 U/L), interlukine-1β (IL-1β: 1254±51 pg/g tissue), malondialdehyde (MDA: 32±1.09 nM/g tissue), and nitric oxide (NO: 224±13.5 nM/g tissue) (P |
| doi_str_mv | 10.1024/0300-9831/a000711 |
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The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p.), and 25, 50 or 100 mg/kg CAR (i.p.) before LPS. LPS increased aspartate transaminase (AST: 162±13 U/L), alanine aminotransferase (ALT: 74.6±2.15 U/L), alkaline phosphatase (ALK-P: 811±51 U/L), interlukine-1β (IL-1β: 1254±51 pg/g tissue), malondialdehyde (MDA: 32±1.09 nM/g tissue), and nitric oxide (NO: 224±13.5 nM/g tissue) (P<0.01-P<0.001) while, decreased total protein(4.08±0.38 g/dl), albumin(2.79±0.16 g/dl), thiol (5.16±0.19 μM/g tissue), superoxide dismutase (SOD: 10.57±0.13 U/g tissue), and catalase (CAT: 0.78±0.02 U/g tissue) compared to control (P<0.001). CAR reversed the effects of LPS (P<0.05-P<0.001). In the rats treated by 100 mg/kg CAR, the indicators were as follows: AST: 118±10.1 U/L, ALT: 42.5±4.13 U/L, ALK-P: 597±39.91 U/L, IL-1β: 494±15 pg/g tissue, and NO: 141±5.35 nM/g tissue. Both 50 and 100 mg/kg CAR corrected oxidative stress indicators and in the group treated by 100 mg/kg CAR, they were: MDA: 23.4±0.91 nM/g tissue, thiol: 7.98±0.18 μM/g tissue, SOD: 21±0.8 U/g tissue, and CAT: 1.12±0.02 U/g tissue(P<0.05-P<0.001). In conclusion, CAR improved liver function, accompanied with antioxidant and antiinflammatory effects.]]></description><identifier>ISSN: 0300-9831</identifier><identifier>EISSN: 1664-2821</identifier><identifier>DOI: 10.1024/0300-9831/a000711</identifier><identifier>PMID: 34024144</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Alanine Transaminase - metabolism ; Alanine Transaminase - pharmacology ; Animals ; Inflammation - chemically induced ; Inflammation - drug therapy ; Lipopolysaccharides - metabolism ; Lipopolysaccharides - toxicity ; Liver - metabolism ; Oxidative Stress ; Rats ; Receptor Protein-Tyrosine Kinases - metabolism ; Receptor Protein-Tyrosine Kinases - pharmacology ; Superoxide Dismutase - metabolism</subject><ispartof>International journal for vitamin and nutrition research, 2023-04, Vol.93 (2), p.111-121</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2521-f267059249bd3d80fc7fdfa9360ce702f93b076dd7767a744785a67a6493b99c3</citedby><cites>FETCH-LOGICAL-c2521-f267059249bd3d80fc7fdfa9360ce702f93b076dd7767a744785a67a6493b99c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34024144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mortazavi, Alireza</creatorcontrib><creatorcontrib>Mohammad Pour Kargar, Hossein</creatorcontrib><creatorcontrib>Beheshti, Farimah</creatorcontrib><creatorcontrib>Anaeigoudari, Akbar</creatorcontrib><creatorcontrib>Vaezi, Gholamhasan</creatorcontrib><creatorcontrib>Hosseini, Mahmoud</creatorcontrib><title>The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats</title><title>International journal for vitamin and nutrition research</title><addtitle>Int J Vitam Nutr Res</addtitle><description><![CDATA[The effect of carvacrol (CAR) on oxidative stress, inflammation, and liver dysfunction induced by lipopolysaccharide (LPS) was explored. The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p.), and 25, 50 or 100 mg/kg CAR (i.p.) before LPS. LPS increased aspartate transaminase (AST: 162±13 U/L), alanine aminotransferase (ALT: 74.6±2.15 U/L), alkaline phosphatase (ALK-P: 811±51 U/L), interlukine-1β (IL-1β: 1254±51 pg/g tissue), malondialdehyde (MDA: 32±1.09 nM/g tissue), and nitric oxide (NO: 224±13.5 nM/g tissue) (P<0.01-P<0.001) while, decreased total protein(4.08±0.38 g/dl), albumin(2.79±0.16 g/dl), thiol (5.16±0.19 μM/g tissue), superoxide dismutase (SOD: 10.57±0.13 U/g tissue), and catalase (CAT: 0.78±0.02 U/g tissue) compared to control (P<0.001). CAR reversed the effects of LPS (P<0.05-P<0.001). In the rats treated by 100 mg/kg CAR, the indicators were as follows: AST: 118±10.1 U/L, ALT: 42.5±4.13 U/L, ALK-P: 597±39.91 U/L, IL-1β: 494±15 pg/g tissue, and NO: 141±5.35 nM/g tissue. Both 50 and 100 mg/kg CAR corrected oxidative stress indicators and in the group treated by 100 mg/kg CAR, they were: MDA: 23.4±0.91 nM/g tissue, thiol: 7.98±0.18 μM/g tissue, SOD: 21±0.8 U/g tissue, and CAT: 1.12±0.02 U/g tissue(P<0.05-P<0.001). In conclusion, CAR improved liver function, accompanied with antioxidant and antiinflammatory effects.]]></description><subject>Alanine Transaminase - metabolism</subject><subject>Alanine Transaminase - pharmacology</subject><subject>Animals</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Lipopolysaccharides - metabolism</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Liver - metabolism</subject><subject>Oxidative Stress</subject><subject>Rats</subject><subject>Receptor Protein-Tyrosine Kinases - metabolism</subject><subject>Receptor Protein-Tyrosine Kinases - pharmacology</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0300-9831</issn><issn>1664-2821</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctq20AUHUpC46b9gGzCLLOw6jsPaaRlMW1aMHSTrsX1PIiKpHHnSib-m35qRsQJZHUP9zwW5zB2I-CrAKk3oACKplZigwBghPjAVqKqdCFrKS7Y6o2_Yp-I_gIoI2r9kV0pne1C6xX7__DouQ_B24l4DNxiOqJNsedx5PGpczh1R89pSp5ozbsx9DgM-RnHNcfR8T7TiYd5tMsvC1xncYqJMuTI6USTHzr7zsmH6Hy_aGfrHd-fcsohHmJ_IrT2EVPn_GJPONFndhmwJ__lfK_Znx_fH7Y_i93v-1_bb7vCylKKIsjKQNlI3eydcjUEa4IL2KgKrDcgQ6P2YCrnjKkMGq1NXWJGlc5E01h1ze5ecg8p_ps9Te3QkfV9j6OPM7WyVKLUEqoyS8WLNPdElHxoD6kbMJ1aAe0yTLsU3y7Ft-dhsuf2HD_vB-_eHK9LqGexD4uT</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Mortazavi, Alireza</creator><creator>Mohammad Pour Kargar, Hossein</creator><creator>Beheshti, Farimah</creator><creator>Anaeigoudari, Akbar</creator><creator>Vaezi, Gholamhasan</creator><creator>Hosseini, Mahmoud</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230401</creationdate><title>The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats</title><author>Mortazavi, Alireza ; Mohammad Pour Kargar, Hossein ; Beheshti, Farimah ; Anaeigoudari, Akbar ; Vaezi, Gholamhasan ; Hosseini, Mahmoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2521-f267059249bd3d80fc7fdfa9360ce702f93b076dd7767a744785a67a6493b99c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alanine Transaminase - metabolism</topic><topic>Alanine Transaminase - pharmacology</topic><topic>Animals</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Lipopolysaccharides - metabolism</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Liver - metabolism</topic><topic>Oxidative Stress</topic><topic>Rats</topic><topic>Receptor Protein-Tyrosine Kinases - metabolism</topic><topic>Receptor Protein-Tyrosine Kinases - pharmacology</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mortazavi, Alireza</creatorcontrib><creatorcontrib>Mohammad Pour Kargar, Hossein</creatorcontrib><creatorcontrib>Beheshti, Farimah</creatorcontrib><creatorcontrib>Anaeigoudari, Akbar</creatorcontrib><creatorcontrib>Vaezi, Gholamhasan</creatorcontrib><creatorcontrib>Hosseini, Mahmoud</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal for vitamin and nutrition research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mortazavi, Alireza</au><au>Mohammad Pour Kargar, Hossein</au><au>Beheshti, Farimah</au><au>Anaeigoudari, Akbar</au><au>Vaezi, Gholamhasan</au><au>Hosseini, Mahmoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats</atitle><jtitle>International journal for vitamin and nutrition research</jtitle><addtitle>Int J Vitam Nutr Res</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>93</volume><issue>2</issue><spage>111</spage><epage>121</epage><pages>111-121</pages><issn>0300-9831</issn><eissn>1664-2821</eissn><abstract><![CDATA[The effect of carvacrol (CAR) on oxidative stress, inflammation, and liver dysfunction induced by lipopolysaccharide (LPS) was explored. The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p.), and 25, 50 or 100 mg/kg CAR (i.p.) before LPS. LPS increased aspartate transaminase (AST: 162±13 U/L), alanine aminotransferase (ALT: 74.6±2.15 U/L), alkaline phosphatase (ALK-P: 811±51 U/L), interlukine-1β (IL-1β: 1254±51 pg/g tissue), malondialdehyde (MDA: 32±1.09 nM/g tissue), and nitric oxide (NO: 224±13.5 nM/g tissue) (P<0.01-P<0.001) while, decreased total protein(4.08±0.38 g/dl), albumin(2.79±0.16 g/dl), thiol (5.16±0.19 μM/g tissue), superoxide dismutase (SOD: 10.57±0.13 U/g tissue), and catalase (CAT: 0.78±0.02 U/g tissue) compared to control (P<0.001). CAR reversed the effects of LPS (P<0.05-P<0.001). In the rats treated by 100 mg/kg CAR, the indicators were as follows: AST: 118±10.1 U/L, ALT: 42.5±4.13 U/L, ALK-P: 597±39.91 U/L, IL-1β: 494±15 pg/g tissue, and NO: 141±5.35 nM/g tissue. Both 50 and 100 mg/kg CAR corrected oxidative stress indicators and in the group treated by 100 mg/kg CAR, they were: MDA: 23.4±0.91 nM/g tissue, thiol: 7.98±0.18 μM/g tissue, SOD: 21±0.8 U/g tissue, and CAT: 1.12±0.02 U/g tissue(P<0.05-P<0.001). In conclusion, CAR improved liver function, accompanied with antioxidant and antiinflammatory effects.]]></abstract><cop>Switzerland</cop><pmid>34024144</pmid><doi>10.1024/0300-9831/a000711</doi><tpages>11</tpages></addata></record> |
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| subjects | Alanine Transaminase - metabolism Alanine Transaminase - pharmacology Animals Inflammation - chemically induced Inflammation - drug therapy Lipopolysaccharides - metabolism Lipopolysaccharides - toxicity Liver - metabolism Oxidative Stress Rats Receptor Protein-Tyrosine Kinases - metabolism Receptor Protein-Tyrosine Kinases - pharmacology Superoxide Dismutase - metabolism |
| title | The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats |
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