High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity

The KIR (killer-cell immunoglobulin-like receptor) region is characterized by structural variation and high sequence similarity among genes, imposing technical difficulties for analysis. We undertook the most comprehensive study to date of KIR genetic diversity in a large population sample, applying...

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Veröffentlicht in:	Frontiers in immunology 2021-05, Vol.12, p.674778-674778, Article 674778
Hauptverfasser:	Amorim, Leonardo M., Augusto, Danillo G., Nemat-Gorgani, Neda, Montero-Martin, Gonzalo, Marin, Wesley M., Shams, Hengameh, Dandekar, Ravi, Caillier, Stacy, Parham, Peter, Fernandez-Vina, Marcelo A., Oksenberg, Jorge R., Norman, Paul J., Hollenbach, Jill A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Cohort Studies Genomic Structural Variation - genetics Genotype Haplotypes high resolution High-Throughput Nucleotide Sequencing - methods Humans Immunology Life Sciences & Biomedicine NGS NK receptors North America Polymorphism, Genetic Polymorphism, Single Nucleotide population Receptors, Immunologic - genetics Receptors, KIR - genetics Science & Technology sequencing White People - genetics
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