Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model
The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research. The present study aims to design a nanoplatform that offers the opportunity to enhance antitumor activity while min...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2021-06, Vol.9 (22), p.451-4522 |
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| creator | Nosrati, Hamed Baghdadchi, Yasamin Abbasi, Reza Barsbay, Murat Ghaffarlou, Mohammadreza Abhari, Fatemeh Mohammadi, Ali Kavetskyy, Taras Bochani, Shayesteh Rezaeejam, Hamed Davaran, Soodabeh Danafar, Hossein |
| description | The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research. The present study aims to design a nanoplatform that offers the opportunity to enhance antitumor activity while minimizing side effects. Given the Au-mediated X-ray radiation enhancement and the ability of Fe-based nanomaterials to create reactive oxygen species (ROS) and DNA damage, we anticipated that bimetallic Fe
3
O
4
-Au heterodimer would bring strong radiosensitizing capacity. Fe
3
O
4
-Au heterodimer surface was covered with bovine serum albumin (BSA) to achieve good surface functionality, stability and prolonged blood circulation. Folic acid (FA) moieties were added to the nanoformulation to increase tumor-homing, specificity and uptake. Finally, curcumin (CUR) was incorporated into the nanoparticle to function as a natural anticancer agent. The integration of all these components has yielded a single nanoplatform, Fe
3
O
4
-Au-BSA-FA-CUR, capable of successfully fulfilling the mission of superadditive cancer therapy to avoid the risks of organ removal surgery. The efficacy of the proposed nanoplatform was investigated
in vitro
and
in vivo
. High radiosensitizing ability, X-ray-induced ROS generation and DNA damage, and good biocompatibility were demonstrated through
in vitro
experiments. Also, the administration of Fe
3
O
4
-Au-BSA-FA-CUR with X-ray irradiation completely eradicated the tumor without any mortality and toxicity in healthy tissues
in vivo
. Our results highlight the potential of CUR-loaded Fe
3
O
4
-Au-BSA-FA heteronanostructure to enable synergistic localized radiochemotherapy and open up a new door to attractive possibilities that warrant further exploration.
The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research. |
| doi_str_mv | 10.1039/d0tb02561e |
| format | Article |
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3
O
4
-Au heterodimer would bring strong radiosensitizing capacity. Fe
3
O
4
-Au heterodimer surface was covered with bovine serum albumin (BSA) to achieve good surface functionality, stability and prolonged blood circulation. Folic acid (FA) moieties were added to the nanoformulation to increase tumor-homing, specificity and uptake. Finally, curcumin (CUR) was incorporated into the nanoparticle to function as a natural anticancer agent. The integration of all these components has yielded a single nanoplatform, Fe
3
O
4
-Au-BSA-FA-CUR, capable of successfully fulfilling the mission of superadditive cancer therapy to avoid the risks of organ removal surgery. The efficacy of the proposed nanoplatform was investigated
in vitro
and
in vivo
. High radiosensitizing ability, X-ray-induced ROS generation and DNA damage, and good biocompatibility were demonstrated through
in vitro
experiments. Also, the administration of Fe
3
O
4
-Au-BSA-FA-CUR with X-ray irradiation completely eradicated the tumor without any mortality and toxicity in healthy tissues
in vivo
. Our results highlight the potential of CUR-loaded Fe
3
O
4
-Au-BSA-FA heteronanostructure to enable synergistic localized radiochemotherapy and open up a new door to attractive possibilities that warrant further exploration.
The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d0tb02561e</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Animal models ; Anticancer properties ; Antitumor activity ; Antitumor agents ; Bimetals ; Biocompatibility ; Blood circulation ; Bovine serum albumin ; Breast cancer ; Cancer therapies ; Chemoradiotherapy ; Curcumin ; Damage ; Deoxyribonucleic acid ; DNA ; DNA damage ; Folic acid ; Homing behavior ; In vivo methods and tests ; Iron oxides ; Irradiation ; Nanomaterials ; Nanoparticles ; Nanotechnology ; Organ removal ; Radiosensitizers ; Reactive oxygen species ; Serum albumin ; Side effects ; Surface stability ; Surgery ; Therapy ; Toxicity ; X ray irradiation ; X-rays</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2021-06, Vol.9 (22), p.451-4522</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-dc843f4c61b277458c9bce3a4f942c6bf626db76f1a930251c3edc9b3d4569e3</citedby><cites>FETCH-LOGICAL-c314t-dc843f4c61b277458c9bce3a4f942c6bf626db76f1a930251c3edc9b3d4569e3</cites><orcidid>0000-0003-0788-4446 ; 0000-0002-7487-8188 ; 0000-0001-8956-7895</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Nosrati, Hamed</creatorcontrib><creatorcontrib>Baghdadchi, Yasamin</creatorcontrib><creatorcontrib>Abbasi, Reza</creatorcontrib><creatorcontrib>Barsbay, Murat</creatorcontrib><creatorcontrib>Ghaffarlou, Mohammadreza</creatorcontrib><creatorcontrib>Abhari, Fatemeh</creatorcontrib><creatorcontrib>Mohammadi, Ali</creatorcontrib><creatorcontrib>Kavetskyy, Taras</creatorcontrib><creatorcontrib>Bochani, Shayesteh</creatorcontrib><creatorcontrib>Rezaeejam, Hamed</creatorcontrib><creatorcontrib>Davaran, Soodabeh</creatorcontrib><creatorcontrib>Danafar, Hossein</creatorcontrib><title>Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><description>The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research. The present study aims to design a nanoplatform that offers the opportunity to enhance antitumor activity while minimizing side effects. Given the Au-mediated X-ray radiation enhancement and the ability of Fe-based nanomaterials to create reactive oxygen species (ROS) and DNA damage, we anticipated that bimetallic Fe
3
O
4
-Au heterodimer would bring strong radiosensitizing capacity. Fe
3
O
4
-Au heterodimer surface was covered with bovine serum albumin (BSA) to achieve good surface functionality, stability and prolonged blood circulation. Folic acid (FA) moieties were added to the nanoformulation to increase tumor-homing, specificity and uptake. Finally, curcumin (CUR) was incorporated into the nanoparticle to function as a natural anticancer agent. The integration of all these components has yielded a single nanoplatform, Fe
3
O
4
-Au-BSA-FA-CUR, capable of successfully fulfilling the mission of superadditive cancer therapy to avoid the risks of organ removal surgery. The efficacy of the proposed nanoplatform was investigated
in vitro
and
in vivo
. High radiosensitizing ability, X-ray-induced ROS generation and DNA damage, and good biocompatibility were demonstrated through
in vitro
experiments. Also, the administration of Fe
3
O
4
-Au-BSA-FA-CUR with X-ray irradiation completely eradicated the tumor without any mortality and toxicity in healthy tissues
in vivo
. Our results highlight the potential of CUR-loaded Fe
3
O
4
-Au-BSA-FA heteronanostructure to enable synergistic localized radiochemotherapy and open up a new door to attractive possibilities that warrant further exploration.
The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research.</description><subject>Animal models</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Antitumor agents</subject><subject>Bimetals</subject><subject>Biocompatibility</subject><subject>Blood circulation</subject><subject>Bovine serum albumin</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Chemoradiotherapy</subject><subject>Curcumin</subject><subject>Damage</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Folic acid</subject><subject>Homing behavior</subject><subject>In vivo methods and tests</subject><subject>Iron oxides</subject><subject>Irradiation</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Organ removal</subject><subject>Radiosensitizers</subject><subject>Reactive oxygen species</subject><subject>Serum albumin</subject><subject>Side effects</subject><subject>Surface stability</subject><subject>Surgery</subject><subject>Therapy</subject><subject>Toxicity</subject><subject>X ray irradiation</subject><subject>X-rays</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpd0UFLwzAUB_AiCo65i3ch4EWEatKkXXPUOXUw8NKDt5Imry6jTWaSgvPgZzdzMsFcXgi_PF7yT5Jzgm8IpvxW4dDgLC8IHCWjDOc4neakPD7s8etpMvF-jeMqSVFSNkq-Fs4aZD-0AiSMQm-2U6jRPQTRdVoiJ5S2HozXQX-C86i1Dvmtkat4zw4ehaGPJ3IFsUQrgo79wgqc2GyRNohVBDUOhA9ICiPBoX5w2gDqrYLuLDlpRedh8lvHSfU4r2bP6fLlaTG7W6aSEhZSJUtGWyYL0mTTKctLyRsJVLCWs0wWTVtkhWqmRUsEp_ELiKSgoqGK5QUHOk6u9m03zr4P4EPday-h64SB-Ig6yynJGea0jPTyH13bwZk43E7xLCOM86iu90o6672Dtt443Qu3rQmud2HUD7i6_wljHvHFHjsvD-4vLPoNJo-ICQ</recordid><startdate>20210602</startdate><enddate>20210602</enddate><creator>Nosrati, Hamed</creator><creator>Baghdadchi, Yasamin</creator><creator>Abbasi, Reza</creator><creator>Barsbay, Murat</creator><creator>Ghaffarlou, Mohammadreza</creator><creator>Abhari, Fatemeh</creator><creator>Mohammadi, Ali</creator><creator>Kavetskyy, Taras</creator><creator>Bochani, Shayesteh</creator><creator>Rezaeejam, Hamed</creator><creator>Davaran, Soodabeh</creator><creator>Danafar, Hossein</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0788-4446</orcidid><orcidid>https://orcid.org/0000-0002-7487-8188</orcidid><orcidid>https://orcid.org/0000-0001-8956-7895</orcidid></search><sort><creationdate>20210602</creationdate><title>Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model</title><author>Nosrati, Hamed ; Baghdadchi, Yasamin ; Abbasi, Reza ; Barsbay, Murat ; Ghaffarlou, Mohammadreza ; Abhari, Fatemeh ; Mohammadi, Ali ; Kavetskyy, Taras ; Bochani, Shayesteh ; Rezaeejam, Hamed ; Davaran, Soodabeh ; Danafar, Hossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-dc843f4c61b277458c9bce3a4f942c6bf626db76f1a930251c3edc9b3d4569e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animal models</topic><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Antitumor agents</topic><topic>Bimetals</topic><topic>Biocompatibility</topic><topic>Blood circulation</topic><topic>Bovine serum albumin</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Chemoradiotherapy</topic><topic>Curcumin</topic><topic>Damage</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Folic acid</topic><topic>Homing behavior</topic><topic>In vivo methods and tests</topic><topic>Iron oxides</topic><topic>Irradiation</topic><topic>Nanomaterials</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Organ removal</topic><topic>Radiosensitizers</topic><topic>Reactive oxygen species</topic><topic>Serum albumin</topic><topic>Side effects</topic><topic>Surface stability</topic><topic>Surgery</topic><topic>Therapy</topic><topic>Toxicity</topic><topic>X ray irradiation</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nosrati, Hamed</creatorcontrib><creatorcontrib>Baghdadchi, Yasamin</creatorcontrib><creatorcontrib>Abbasi, Reza</creatorcontrib><creatorcontrib>Barsbay, Murat</creatorcontrib><creatorcontrib>Ghaffarlou, Mohammadreza</creatorcontrib><creatorcontrib>Abhari, Fatemeh</creatorcontrib><creatorcontrib>Mohammadi, Ali</creatorcontrib><creatorcontrib>Kavetskyy, Taras</creatorcontrib><creatorcontrib>Bochani, Shayesteh</creatorcontrib><creatorcontrib>Rezaeejam, Hamed</creatorcontrib><creatorcontrib>Davaran, Soodabeh</creatorcontrib><creatorcontrib>Danafar, Hossein</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nosrati, Hamed</au><au>Baghdadchi, Yasamin</au><au>Abbasi, Reza</au><au>Barsbay, Murat</au><au>Ghaffarlou, Mohammadreza</au><au>Abhari, Fatemeh</au><au>Mohammadi, Ali</au><au>Kavetskyy, Taras</au><au>Bochani, Shayesteh</au><au>Rezaeejam, Hamed</au><au>Davaran, Soodabeh</au><au>Danafar, Hossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><date>2021-06-02</date><risdate>2021</risdate><volume>9</volume><issue>22</issue><spage>451</spage><epage>4522</epage><pages>451-4522</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research. The present study aims to design a nanoplatform that offers the opportunity to enhance antitumor activity while minimizing side effects. Given the Au-mediated X-ray radiation enhancement and the ability of Fe-based nanomaterials to create reactive oxygen species (ROS) and DNA damage, we anticipated that bimetallic Fe
3
O
4
-Au heterodimer would bring strong radiosensitizing capacity. Fe
3
O
4
-Au heterodimer surface was covered with bovine serum albumin (BSA) to achieve good surface functionality, stability and prolonged blood circulation. Folic acid (FA) moieties were added to the nanoformulation to increase tumor-homing, specificity and uptake. Finally, curcumin (CUR) was incorporated into the nanoparticle to function as a natural anticancer agent. The integration of all these components has yielded a single nanoplatform, Fe
3
O
4
-Au-BSA-FA-CUR, capable of successfully fulfilling the mission of superadditive cancer therapy to avoid the risks of organ removal surgery. The efficacy of the proposed nanoplatform was investigated
in vitro
and
in vivo
. High radiosensitizing ability, X-ray-induced ROS generation and DNA damage, and good biocompatibility were demonstrated through
in vitro
experiments. Also, the administration of Fe
3
O
4
-Au-BSA-FA-CUR with X-ray irradiation completely eradicated the tumor without any mortality and toxicity in healthy tissues
in vivo
. Our results highlight the potential of CUR-loaded Fe
3
O
4
-Au-BSA-FA heteronanostructure to enable synergistic localized radiochemotherapy and open up a new door to attractive possibilities that warrant further exploration.
The development of highly integrated multifunctional nanomaterials with a superadditive therapeutic effect and good safety is an urgent but challenging task in cancer therapy research.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d0tb02561e</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-0788-4446</orcidid><orcidid>https://orcid.org/0000-0002-7487-8188</orcidid><orcidid>https://orcid.org/0000-0001-8956-7895</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2021-06, Vol.9 (22), p.451-4522 |
| issn | 2050-750X 2050-7518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2531540938 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Animal models Anticancer properties Antitumor activity Antitumor agents Bimetals Biocompatibility Blood circulation Bovine serum albumin Breast cancer Cancer therapies Chemoradiotherapy Curcumin Damage Deoxyribonucleic acid DNA DNA damage Folic acid Homing behavior In vivo methods and tests Iron oxides Irradiation Nanomaterials Nanoparticles Nanotechnology Organ removal Radiosensitizers Reactive oxygen species Serum albumin Side effects Surface stability Surgery Therapy Toxicity X ray irradiation X-rays |
| title | Iron oxide and gold bimetallic radiosensitizers for synchronous tumor chemoradiation therapy in 4T1 breast cancer murine model |
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