Linkage of resistance-associated substitutions in GT1 sofosbuvir + NS5A inhibitor failures treated with glecaprevir/pibrentasvir

Retreatment with glecaprevir/pibrentasvir (G/P) resulted in a rate of sustained virologic response 12 weeks after treatment completion (SVR12) of >90% in HCV genotype 1 (GT1) patients who previously failed a regimen of sofosbuvir plus an NS5A inhibitor (NS5Ai). This study investigated the prevale...

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Veröffentlicht in:	Journal of hepatology 2021-10, Vol.75 (4), p.820-828
Hauptverfasser:	Wang, Gary P., Schnell, Gretja L., Kort, Jens J., Sidhu, Gurjit S., Schuster, Layla, Tripathi, Rakesh L., Larsen, Lois, Michael, Larry C., Bergquist, Ken, Magee, Ashley, Patel, Chandni B., Whitlock, Joan A., Tamashiro, Ryan, Peter, Joy A., Fried, Michael W., Nelson, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral agents Antiviral Agents - administration & dosage Antiviral Agents - metabolism Benzimidazoles - pharmacology Benzimidazoles - therapeutic use Chronic infection Cirrhosis Drug Combinations Drug Resistance - immunology Female Genotypes Glecaprevir/Pibrentasvir Hepatitis C Hepatitis C - drug therapy Hepatitis C - epidemiology Hepatitis C - physiopathology Hepatitis C therapy Humans Liver cirrhosis Longitudinal Studies Male Middle Aged Multiple-linked substitutions Mutation Next-generation sequencing NS5A resistance Patients Persistence of treatment-emergent substitutions Pyrrolidines - pharmacology Pyrrolidines - therapeutic use Quinoxalines - administration & dosage Quinoxalines - pharmacology Quinoxalines - therapeutic use Resistance-associated substitutions Ribavirin RNA-Dependent RNA Polymerase - antagonists & inhibitors RNA-Dependent RNA Polymerase - pharmacology Sofosbuvir - administration & dosage Sofosbuvir - metabolism Sulfonamides - pharmacology Sulfonamides - therapeutic use Treatment failure Treatment-emergent RASs United States - epidemiology Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - pharmacology
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