The prognostic impact of the serum heart-type fatty acid-binding protein level in patients with sepsis who were admitted to the non-surgical intensive-care unit
Ongoing myocardial damage at the acme of the sepsis status has not been sufficiently evaluated. The clinical data of 160 sepsis patients who require intensive care and 127 outpatients with chronic heart failure (HF) were compared as a retrospective cohort study. Thereafter, the sepsis patients were...
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| Veröffentlicht in: | Heart and vessels 2021-11, Vol.36 (11), p.1765-1774 |
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| creator | Tani, Kenichi Shirakabe, Akihiro Kobayashi, Nobuaki Okazaki, Hirotake Matsushita, Masato Shibata, Yusaku Shigihara, Shota Sawatani, Tomofumi Otsuka, Yusuke Takayasu, Tsutomu Asano, Miwako Nomura, Akiko Hata, Noritake Asai, Kuniya Shimizu, Wataru |
| description | Ongoing myocardial damage at the acme of the sepsis status has not been sufficiently evaluated. The clinical data of 160 sepsis patients who require intensive care and 127 outpatients with chronic heart failure (HF) were compared as a retrospective cohort study. Thereafter, the sepsis patients were divided into 3 groups according to the serum heart-type fatty acid-binding protein (H-FABP) quartiles [low H-FABP = Q1 (
n
= 39), middle H-FABP = Q2/Q3 (
n
= 81), and high H-FABP = Q4 group (
n
= 40)]. The H-FABP level was measured within 15 min of admission. The serum H-FABP levels in the sepsis patients [26.6 (9.3–79.0) ng/ml] were significantly higher than in the choric HF patients [6.6 (4.6–9.7) ng/ml]. A Kaplan–Meier curve showed that the survival rate of the high-H-FABP group was significantly lower than that of the middle- and low-H-FABP groups. The multivariate Cox regression analysis for the 365-day mortality showed that the high-H-FABP group (hazard ratio: 6.544, 95% confidence interval [CI] 2.026–21.140;
p
= 0.002) was an independent predictor of the 365-day mortality. The same trend in the prognostic impact was significantly (
p
= 0.015) observed in the cohort that had not been suffering from the cardiac disease before admission. The serum H-FABP level was an independent predictor of the 365-day mortality in the patients who were emergently hospitalized in the intensive-care unit due to sepsis. Ongoing myocardial damage was detected in the majority of patients with sepsis, suggesting that ongoing myocardial damage might be a candidate predictor of adverse outcomes in sepsis patients. |
| doi_str_mv | 10.1007/s00380-021-01865-4 |
| format | Article |
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n
= 39), middle H-FABP = Q2/Q3 (
n
= 81), and high H-FABP = Q4 group (
n
= 40)]. The H-FABP level was measured within 15 min of admission. The serum H-FABP levels in the sepsis patients [26.6 (9.3–79.0) ng/ml] were significantly higher than in the choric HF patients [6.6 (4.6–9.7) ng/ml]. A Kaplan–Meier curve showed that the survival rate of the high-H-FABP group was significantly lower than that of the middle- and low-H-FABP groups. The multivariate Cox regression analysis for the 365-day mortality showed that the high-H-FABP group (hazard ratio: 6.544, 95% confidence interval [CI] 2.026–21.140;
p
= 0.002) was an independent predictor of the 365-day mortality. The same trend in the prognostic impact was significantly (
p
= 0.015) observed in the cohort that had not been suffering from the cardiac disease before admission. The serum H-FABP level was an independent predictor of the 365-day mortality in the patients who were emergently hospitalized in the intensive-care unit due to sepsis. Ongoing myocardial damage was detected in the majority of patients with sepsis, suggesting that ongoing myocardial damage might be a candidate predictor of adverse outcomes in sepsis patients.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-021-01865-4</identifier><identifier>PMID: 34028584</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Biomarkers ; Biomedical Engineering and Bioengineering ; Cardiac Surgery ; Cardiology ; Confidence intervals ; Congestive heart failure ; Coronary artery disease ; Damage detection ; Fatty Acid Binding Protein 3 - chemistry ; Fatty Acid Binding Protein 3 - metabolism ; Fatty acid-binding protein ; Fatty Acid-Binding Proteins ; Fatty acids ; Humans ; Medicine ; Medicine & Public Health ; Mortality ; Original Article ; Patients ; Prognosis ; Proteins ; Quartiles ; Regression analysis ; Retrospective Studies ; Sepsis ; Sepsis - diagnosis ; Statistical analysis ; Survival ; Vascular Surgery</subject><ispartof>Heart and vessels, 2021-11, Vol.36 (11), p.1765-1774</ispartof><rights>Springer Japan KK, part of Springer Nature 2021</rights><rights>2021. Springer Japan KK, part of Springer Nature.</rights><rights>Springer Japan KK, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-482e16963f37c9ac5950c3f05b59497f976252cecb33045ebff49b18c76f07f33</citedby><cites>FETCH-LOGICAL-c399t-482e16963f37c9ac5950c3f05b59497f976252cecb33045ebff49b18c76f07f33</cites><orcidid>0000-0001-8894-3297</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-021-01865-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-021-01865-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34028584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tani, Kenichi</creatorcontrib><creatorcontrib>Shirakabe, Akihiro</creatorcontrib><creatorcontrib>Kobayashi, Nobuaki</creatorcontrib><creatorcontrib>Okazaki, Hirotake</creatorcontrib><creatorcontrib>Matsushita, Masato</creatorcontrib><creatorcontrib>Shibata, Yusaku</creatorcontrib><creatorcontrib>Shigihara, Shota</creatorcontrib><creatorcontrib>Sawatani, Tomofumi</creatorcontrib><creatorcontrib>Otsuka, Yusuke</creatorcontrib><creatorcontrib>Takayasu, Tsutomu</creatorcontrib><creatorcontrib>Asano, Miwako</creatorcontrib><creatorcontrib>Nomura, Akiko</creatorcontrib><creatorcontrib>Hata, Noritake</creatorcontrib><creatorcontrib>Asai, Kuniya</creatorcontrib><creatorcontrib>Shimizu, Wataru</creatorcontrib><title>The prognostic impact of the serum heart-type fatty acid-binding protein level in patients with sepsis who were admitted to the non-surgical intensive-care unit</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>Ongoing myocardial damage at the acme of the sepsis status has not been sufficiently evaluated. The clinical data of 160 sepsis patients who require intensive care and 127 outpatients with chronic heart failure (HF) were compared as a retrospective cohort study. Thereafter, the sepsis patients were divided into 3 groups according to the serum heart-type fatty acid-binding protein (H-FABP) quartiles [low H-FABP = Q1 (
n
= 39), middle H-FABP = Q2/Q3 (
n
= 81), and high H-FABP = Q4 group (
n
= 40)]. The H-FABP level was measured within 15 min of admission. The serum H-FABP levels in the sepsis patients [26.6 (9.3–79.0) ng/ml] were significantly higher than in the choric HF patients [6.6 (4.6–9.7) ng/ml]. A Kaplan–Meier curve showed that the survival rate of the high-H-FABP group was significantly lower than that of the middle- and low-H-FABP groups. The multivariate Cox regression analysis for the 365-day mortality showed that the high-H-FABP group (hazard ratio: 6.544, 95% confidence interval [CI] 2.026–21.140;
p
= 0.002) was an independent predictor of the 365-day mortality. The same trend in the prognostic impact was significantly (
p
= 0.015) observed in the cohort that had not been suffering from the cardiac disease before admission. The serum H-FABP level was an independent predictor of the 365-day mortality in the patients who were emergently hospitalized in the intensive-care unit due to sepsis. Ongoing myocardial damage was detected in the majority of patients with sepsis, suggesting that ongoing myocardial damage might be a candidate predictor of adverse outcomes in sepsis patients.</description><subject>Biomarkers</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Confidence intervals</subject><subject>Congestive heart failure</subject><subject>Coronary artery disease</subject><subject>Damage detection</subject><subject>Fatty Acid Binding Protein 3 - chemistry</subject><subject>Fatty Acid Binding Protein 3 - metabolism</subject><subject>Fatty acid-binding protein</subject><subject>Fatty Acid-Binding Proteins</subject><subject>Fatty acids</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Original Article</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Quartiles</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Sepsis</subject><subject>Sepsis - diagnosis</subject><subject>Statistical analysis</subject><subject>Survival</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAUhUVpaSZJX6CLIuimG7X6sSxrWUL6A4FskrWQ5asZBVt2JTlh3iaPWk0mbaGLrHThfuecKw5C7xn9zChVXzKloqOEckYo61pJmldow1omCZdKvEYbqhklneDqBJ3mfEcpk5rpt-hENJR3sms26PFmB3hJ8zbOuQSHw7RYV_DscamLDGmd8A5sKqTsF8DelrLH1oWB9CEOIW4P4gIh4hHuYcR1WGwJEEvGD6HsqsWSQ513M36ABNgOUygFBlzmp4g4R5LXtA3OHtQFYg73QJyt7BpDOUdvvB0zvHt-z9Dtt8ubix_k6vr7z4uvV8QJrQtpOg6s1a3wQjltndSSOuGp7KVutPJatVxyB64XgjYSeu8b3bPOqdZT5YU4Q5-OvvU_v1bIxUwhOxhHG2Fes-FSMCmEFG1FP_6H3s1rivW6SimlmprdVIofKZfmnBN4s6Qw2bQ3jJpDf-bYn6n9maf-zEH04dl67ScY_kr-FFYBcQRyXcUtpH_ZL9j-Bpe3qAE</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Tani, Kenichi</creator><creator>Shirakabe, Akihiro</creator><creator>Kobayashi, Nobuaki</creator><creator>Okazaki, Hirotake</creator><creator>Matsushita, Masato</creator><creator>Shibata, Yusaku</creator><creator>Shigihara, Shota</creator><creator>Sawatani, Tomofumi</creator><creator>Otsuka, Yusuke</creator><creator>Takayasu, Tsutomu</creator><creator>Asano, Miwako</creator><creator>Nomura, Akiko</creator><creator>Hata, Noritake</creator><creator>Asai, Kuniya</creator><creator>Shimizu, Wataru</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8894-3297</orcidid></search><sort><creationdate>20211101</creationdate><title>The prognostic impact of the serum heart-type fatty acid-binding protein level in patients with sepsis who were admitted to the non-surgical intensive-care unit</title><author>Tani, Kenichi ; Shirakabe, Akihiro ; Kobayashi, Nobuaki ; Okazaki, Hirotake ; Matsushita, Masato ; Shibata, Yusaku ; Shigihara, Shota ; Sawatani, Tomofumi ; Otsuka, Yusuke ; Takayasu, Tsutomu ; Asano, Miwako ; Nomura, Akiko ; Hata, Noritake ; Asai, Kuniya ; Shimizu, Wataru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-482e16963f37c9ac5950c3f05b59497f976252cecb33045ebff49b18c76f07f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Confidence intervals</topic><topic>Congestive heart failure</topic><topic>Coronary artery disease</topic><topic>Damage detection</topic><topic>Fatty Acid Binding Protein 3 - chemistry</topic><topic>Fatty Acid Binding Protein 3 - metabolism</topic><topic>Fatty acid-binding protein</topic><topic>Fatty Acid-Binding Proteins</topic><topic>Fatty acids</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Original Article</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Quartiles</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Sepsis</topic><topic>Sepsis - diagnosis</topic><topic>Statistical analysis</topic><topic>Survival</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tani, Kenichi</creatorcontrib><creatorcontrib>Shirakabe, Akihiro</creatorcontrib><creatorcontrib>Kobayashi, Nobuaki</creatorcontrib><creatorcontrib>Okazaki, Hirotake</creatorcontrib><creatorcontrib>Matsushita, Masato</creatorcontrib><creatorcontrib>Shibata, Yusaku</creatorcontrib><creatorcontrib>Shigihara, Shota</creatorcontrib><creatorcontrib>Sawatani, Tomofumi</creatorcontrib><creatorcontrib>Otsuka, Yusuke</creatorcontrib><creatorcontrib>Takayasu, Tsutomu</creatorcontrib><creatorcontrib>Asano, Miwako</creatorcontrib><creatorcontrib>Nomura, Akiko</creatorcontrib><creatorcontrib>Hata, Noritake</creatorcontrib><creatorcontrib>Asai, Kuniya</creatorcontrib><creatorcontrib>Shimizu, Wataru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tani, Kenichi</au><au>Shirakabe, Akihiro</au><au>Kobayashi, Nobuaki</au><au>Okazaki, Hirotake</au><au>Matsushita, Masato</au><au>Shibata, Yusaku</au><au>Shigihara, Shota</au><au>Sawatani, Tomofumi</au><au>Otsuka, Yusuke</au><au>Takayasu, Tsutomu</au><au>Asano, Miwako</au><au>Nomura, Akiko</au><au>Hata, Noritake</au><au>Asai, Kuniya</au><au>Shimizu, Wataru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic impact of the serum heart-type fatty acid-binding protein level in patients with sepsis who were admitted to the non-surgical intensive-care unit</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>36</volume><issue>11</issue><spage>1765</spage><epage>1774</epage><pages>1765-1774</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>Ongoing myocardial damage at the acme of the sepsis status has not been sufficiently evaluated. The clinical data of 160 sepsis patients who require intensive care and 127 outpatients with chronic heart failure (HF) were compared as a retrospective cohort study. Thereafter, the sepsis patients were divided into 3 groups according to the serum heart-type fatty acid-binding protein (H-FABP) quartiles [low H-FABP = Q1 (
n
= 39), middle H-FABP = Q2/Q3 (
n
= 81), and high H-FABP = Q4 group (
n
= 40)]. The H-FABP level was measured within 15 min of admission. The serum H-FABP levels in the sepsis patients [26.6 (9.3–79.0) ng/ml] were significantly higher than in the choric HF patients [6.6 (4.6–9.7) ng/ml]. A Kaplan–Meier curve showed that the survival rate of the high-H-FABP group was significantly lower than that of the middle- and low-H-FABP groups. The multivariate Cox regression analysis for the 365-day mortality showed that the high-H-FABP group (hazard ratio: 6.544, 95% confidence interval [CI] 2.026–21.140;
p
= 0.002) was an independent predictor of the 365-day mortality. The same trend in the prognostic impact was significantly (
p
= 0.015) observed in the cohort that had not been suffering from the cardiac disease before admission. The serum H-FABP level was an independent predictor of the 365-day mortality in the patients who were emergently hospitalized in the intensive-care unit due to sepsis. Ongoing myocardial damage was detected in the majority of patients with sepsis, suggesting that ongoing myocardial damage might be a candidate predictor of adverse outcomes in sepsis patients.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>34028584</pmid><doi>10.1007/s00380-021-01865-4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8894-3297</orcidid></addata></record> |
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| subjects | Biomarkers Biomedical Engineering and Bioengineering Cardiac Surgery Cardiology Confidence intervals Congestive heart failure Coronary artery disease Damage detection Fatty Acid Binding Protein 3 - chemistry Fatty Acid Binding Protein 3 - metabolism Fatty acid-binding protein Fatty Acid-Binding Proteins Fatty acids Humans Medicine Medicine & Public Health Mortality Original Article Patients Prognosis Proteins Quartiles Regression analysis Retrospective Studies Sepsis Sepsis - diagnosis Statistical analysis Survival Vascular Surgery |
| title | The prognostic impact of the serum heart-type fatty acid-binding protein level in patients with sepsis who were admitted to the non-surgical intensive-care unit |
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