A novel selective mitochondrial-targeted curcumin analog with remarkable cytotoxicity in glioma cells

Naturally occurring polyphenol curcumin (4) or demethoxycurcumin (5) and their synthetic derivatives display promising anticancer activities. However, their further development is limited by low bioavailability and poor selectivity. Thus, a mitochondria-targeted compound 14 (DMC-TPP) was prepared in...

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Veröffentlicht in:	European journal of medicinal chemistry 2021-10, Vol.221, p.113528-113528, Article 113528
Hauptverfasser:	Shi, Lei, Gao, Li-li, Cai, Shi-zhong, Xiong, Qian-wei, Ma, Zhou-rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Curcumin Demethoxycurcumin Glioma Mitochondrial-targeting Thioredoxin reductase
Online-Zugang:	Volltext
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