Fabrication of All-Trans Retinoic Acid loaded Chitosan/Tripolyphosphate Lipid Hybrid Nanoparticles as a Novel Oral Delivery Approach for Management of Diabetic Nephropathy in Rats

The present study aims to formulate all-trans retinoic acid (ATRA) loaded chitosan/tripolyphosphate lipid hybrid nanoparticles (CTLHNs) for enhancing its solubility and oral delivery. This is to improve ATRA therapeutic effect on diabetic nephropathy (DN). CTLHNs were prepared by o/w homogenization,...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2021-09, Vol.110 (9), p.3208-3220
Hauptverfasser:	Asfour, Marwa Hasanein, Salama, Abeer A.A., Mohsen, Amira Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine monophosphate activated protein kinase All-trans retinoic acid Chitosan Diabetic nephropathy Lipid hybrid nanoparticles Liver kinase B1
Online-Zugang:	Volltext
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