Transcriptome landscape of double negative T cells by single-cell RNA sequencing

CD4 and CD8 coreceptor double negative TCRαβ+ T (DNT) cells are increasingly being recognized for their critical and diverse roles in the immune system. However, their molecular and functional signatures remain poorly understood and controversial. Moreover, the majority of studies are descriptive be...

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Veröffentlicht in:	Journal of autoimmunity 2021-07, Vol.121, p.102653-102653, Article 102653
Hauptverfasser:	Yang, Lu, Zhu, Yanbing, Tian, Dan, Wang, Song, Guo, Jincheng, Sun, Guangyong, Jin, Hua, Zhang, Chunpan, Shi, Wen, Gershwin, M. Eric, Zhang, Zhongtao, Zhao, Yi, Zhang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Separation Cells, Cultured Double negative T cell Flow Cytometry Ikaros Transcription Factor - metabolism Inflammation Innate immunity Lymphocyte Activation - genetics Male Mice Primary Cell Culture Regulatory T cells RNA-Seq Single-Cell Analysis Single-cell RNA sequencing T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Transcriptome - immunology Unconventional T cells
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