Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes
Aging is often associated with low-grade systemic inflammation and reduced anabolic hormone levels. To investigate whether lifelong exercise training can decrease the age-related low-grade inflammation and anabolic hormone levels, we examined hormonal and inflammatory parameters among highly-trained...
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| Veröffentlicht in: | Experimental gerontology 2021-08, Vol.151, p.111407-111407, Article 111407 |
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| creator | Barbosa, Lucas Pinheiro da Silva Aguiar, Samuel Santos, Patrick Anderson dos Santos Rosa, Thiago Maciel, Larissa Alves de Deus, Lysleine Alves Neves, Rodrigo Vanerson Passos de Araújo Leite, Patrício Lopes Gutierrez, Sara Duarte Sousa, Caio Victor Korhonen, Marko T. Degens, Hans Simões, Herbert Gustavo |
| description | Aging is often associated with low-grade systemic inflammation and reduced anabolic hormone levels. To investigate whether lifelong exercise training can decrease the age-related low-grade inflammation and anabolic hormone levels, we examined hormonal and inflammatory parameters among highly-trained male masters athletes and age-matched non-athletes.
From 70 elite power and endurance master athletes – EMA (51.3 ± 8.0 yr), 32 young controls - YC (23.7 ± 3.9 yr) and 24 untrained age-matched controls - MAC (47.2 ± 8.0 yr) venous blood was drawn to measure inflammatory parameters (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α] and interleukin-10 [IL-10]) and circulating hormones (luteinizing hormone [LH], total testosterone, estradiol, sex hormone-binding globulin [SHBG] and free androgen index [FAI]).
EMA showed a better anti-inflammatory status than MAC (higher IL-10 and IL-10/IL-6 ratio and lower IL-6), but a lower anti-inflammatory status than YC (higher TNF-α) (p |
| doi_str_mv | 10.1016/j.exger.2021.111407 |
| format | Article |
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From 70 elite power and endurance master athletes – EMA (51.3 ± 8.0 yr), 32 young controls - YC (23.7 ± 3.9 yr) and 24 untrained age-matched controls - MAC (47.2 ± 8.0 yr) venous blood was drawn to measure inflammatory parameters (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α] and interleukin-10 [IL-10]) and circulating hormones (luteinizing hormone [LH], total testosterone, estradiol, sex hormone-binding globulin [SHBG] and free androgen index [FAI]).
EMA showed a better anti-inflammatory status than MAC (higher IL-10 and IL-10/IL-6 ratio and lower IL-6), but a lower anti-inflammatory status than YC (higher TNF-α) (p < 0.05). The MAC group had lower testosterone levels compared to the YC and EMA group (p < 0.05), and lower estradiol levels and testosterone/LH ratio compared to YC (p < 0.05). In the control groups (MAC and YC), testosterone correlated negatively with age and proinflammatory parameters, and positively with anti-inflammatory parameters.
Elite master athletics elevated levels of anti-inflammatory cytokines above that seen in non-athlete peers and mitigated the age-related reduction in testosterone levels.
•Physical exercise mitigates the effects of biological aging.•Healthy lifestyle mitigates the reduction of androgen hormones.•High levels of testosterone indicate higher anti-inflammatory cytokines.</description><identifier>ISSN: 0531-5565</identifier><identifier>EISSN: 1873-6815</identifier><identifier>DOI: 10.1016/j.exger.2021.111407</identifier><identifier>PMID: 34022273</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Athletes ; Biomarkers ; Exercise ; Hormonal profile ; Humans ; Hypogonadism ; Inflammation ; Male ; Master athletes ; Middle Aged ; Older athletes ; Sex Hormone-Binding Globulin ; Testosterone</subject><ispartof>Experimental gerontology, 2021-08, Vol.151, p.111407-111407, Article 111407</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-79cd8ec8af4cf158c44265dcdb1c410152f86457a331c7ca0f2accc981ef5cd53</citedby><cites>FETCH-LOGICAL-c404t-79cd8ec8af4cf158c44265dcdb1c410152f86457a331c7ca0f2accc981ef5cd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.exger.2021.111407$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34022273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbosa, Lucas Pinheiro</creatorcontrib><creatorcontrib>da Silva Aguiar, Samuel</creatorcontrib><creatorcontrib>Santos, Patrick Anderson</creatorcontrib><creatorcontrib>dos Santos Rosa, Thiago</creatorcontrib><creatorcontrib>Maciel, Larissa Alves</creatorcontrib><creatorcontrib>de Deus, Lysleine Alves</creatorcontrib><creatorcontrib>Neves, Rodrigo Vanerson Passos</creatorcontrib><creatorcontrib>de Araújo Leite, Patrício Lopes</creatorcontrib><creatorcontrib>Gutierrez, Sara Duarte</creatorcontrib><creatorcontrib>Sousa, Caio Victor</creatorcontrib><creatorcontrib>Korhonen, Marko T.</creatorcontrib><creatorcontrib>Degens, Hans</creatorcontrib><creatorcontrib>Simões, Herbert Gustavo</creatorcontrib><title>Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes</title><title>Experimental gerontology</title><addtitle>Exp Gerontol</addtitle><description>Aging is often associated with low-grade systemic inflammation and reduced anabolic hormone levels. To investigate whether lifelong exercise training can decrease the age-related low-grade inflammation and anabolic hormone levels, we examined hormonal and inflammatory parameters among highly-trained male masters athletes and age-matched non-athletes.
From 70 elite power and endurance master athletes – EMA (51.3 ± 8.0 yr), 32 young controls - YC (23.7 ± 3.9 yr) and 24 untrained age-matched controls - MAC (47.2 ± 8.0 yr) venous blood was drawn to measure inflammatory parameters (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α] and interleukin-10 [IL-10]) and circulating hormones (luteinizing hormone [LH], total testosterone, estradiol, sex hormone-binding globulin [SHBG] and free androgen index [FAI]).
EMA showed a better anti-inflammatory status than MAC (higher IL-10 and IL-10/IL-6 ratio and lower IL-6), but a lower anti-inflammatory status than YC (higher TNF-α) (p < 0.05). The MAC group had lower testosterone levels compared to the YC and EMA group (p < 0.05), and lower estradiol levels and testosterone/LH ratio compared to YC (p < 0.05). In the control groups (MAC and YC), testosterone correlated negatively with age and proinflammatory parameters, and positively with anti-inflammatory parameters.
Elite master athletics elevated levels of anti-inflammatory cytokines above that seen in non-athlete peers and mitigated the age-related reduction in testosterone levels.
•Physical exercise mitigates the effects of biological aging.•Healthy lifestyle mitigates the reduction of androgen hormones.•High levels of testosterone indicate higher anti-inflammatory cytokines.</description><subject>Adult</subject><subject>Athletes</subject><subject>Biomarkers</subject><subject>Exercise</subject><subject>Hormonal profile</subject><subject>Humans</subject><subject>Hypogonadism</subject><subject>Inflammation</subject><subject>Male</subject><subject>Master athletes</subject><subject>Middle Aged</subject><subject>Older athletes</subject><subject>Sex Hormone-Binding Globulin</subject><subject>Testosterone</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vEzEQhi0EomnhF1RCe-Syqccfu5sDB1QVWqkSEoKz5czOUqdeO9hOP_49TtP2yMWWPM_rmXkYOwW-BA7d2WZJD38oLQUXsAQAxfs3bAFDL9tuAP2WLbiW0Grd6SN2nPOGc94JCe_ZkVRcCNHLBZt_krfFxZBv3LZZU7knCo0Lk7fzbEtMj83axdmmW0q5sWFsCuUSc6EUAzWe7sjnyjez9VSPfaGx5cZT5Z74EEP78vCBvZusz_Tx-T5hv79d_Dq_bK9_fL86_3rdouKqtP0Kx4FwsJPCCfSASolOjziuAVXdXYtp6JTurZSAPVo-CYuIqwFo0jhqecI-H_7dpvh3Vwc2s8tI3ttAcZeNqGIErHg3VFQeUEwx50ST2SZX9300wM3es9mYJ89m79kcPNfUp-cGu_VM42vmRWwFvhyAqofuXI1ndBSQRpcIixmj-2-DfwxdklE</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Barbosa, Lucas Pinheiro</creator><creator>da Silva Aguiar, Samuel</creator><creator>Santos, Patrick Anderson</creator><creator>dos Santos Rosa, Thiago</creator><creator>Maciel, Larissa Alves</creator><creator>de Deus, Lysleine Alves</creator><creator>Neves, Rodrigo Vanerson Passos</creator><creator>de Araújo Leite, Patrício Lopes</creator><creator>Gutierrez, Sara Duarte</creator><creator>Sousa, Caio Victor</creator><creator>Korhonen, Marko T.</creator><creator>Degens, Hans</creator><creator>Simões, Herbert Gustavo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202108</creationdate><title>Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes</title><author>Barbosa, Lucas Pinheiro ; da Silva Aguiar, Samuel ; Santos, Patrick Anderson ; dos Santos Rosa, Thiago ; Maciel, Larissa Alves ; de Deus, Lysleine Alves ; Neves, Rodrigo Vanerson Passos ; de Araújo Leite, Patrício Lopes ; Gutierrez, Sara Duarte ; Sousa, Caio Victor ; Korhonen, Marko T. ; Degens, Hans ; Simões, Herbert Gustavo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-79cd8ec8af4cf158c44265dcdb1c410152f86457a331c7ca0f2accc981ef5cd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Athletes</topic><topic>Biomarkers</topic><topic>Exercise</topic><topic>Hormonal profile</topic><topic>Humans</topic><topic>Hypogonadism</topic><topic>Inflammation</topic><topic>Male</topic><topic>Master athletes</topic><topic>Middle Aged</topic><topic>Older athletes</topic><topic>Sex Hormone-Binding Globulin</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbosa, Lucas Pinheiro</creatorcontrib><creatorcontrib>da Silva Aguiar, Samuel</creatorcontrib><creatorcontrib>Santos, Patrick Anderson</creatorcontrib><creatorcontrib>dos Santos Rosa, Thiago</creatorcontrib><creatorcontrib>Maciel, Larissa Alves</creatorcontrib><creatorcontrib>de Deus, Lysleine Alves</creatorcontrib><creatorcontrib>Neves, Rodrigo Vanerson Passos</creatorcontrib><creatorcontrib>de Araújo Leite, Patrício Lopes</creatorcontrib><creatorcontrib>Gutierrez, Sara Duarte</creatorcontrib><creatorcontrib>Sousa, Caio Victor</creatorcontrib><creatorcontrib>Korhonen, Marko T.</creatorcontrib><creatorcontrib>Degens, Hans</creatorcontrib><creatorcontrib>Simões, Herbert Gustavo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbosa, Lucas Pinheiro</au><au>da Silva Aguiar, Samuel</au><au>Santos, Patrick Anderson</au><au>dos Santos Rosa, Thiago</au><au>Maciel, Larissa Alves</au><au>de Deus, Lysleine Alves</au><au>Neves, Rodrigo Vanerson Passos</au><au>de Araújo Leite, Patrício Lopes</au><au>Gutierrez, Sara Duarte</au><au>Sousa, Caio Victor</au><au>Korhonen, Marko T.</au><au>Degens, Hans</au><au>Simões, Herbert Gustavo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes</atitle><jtitle>Experimental gerontology</jtitle><addtitle>Exp Gerontol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>151</volume><spage>111407</spage><epage>111407</epage><pages>111407-111407</pages><artnum>111407</artnum><issn>0531-5565</issn><eissn>1873-6815</eissn><abstract>Aging is often associated with low-grade systemic inflammation and reduced anabolic hormone levels. To investigate whether lifelong exercise training can decrease the age-related low-grade inflammation and anabolic hormone levels, we examined hormonal and inflammatory parameters among highly-trained male masters athletes and age-matched non-athletes.
From 70 elite power and endurance master athletes – EMA (51.3 ± 8.0 yr), 32 young controls - YC (23.7 ± 3.9 yr) and 24 untrained age-matched controls - MAC (47.2 ± 8.0 yr) venous blood was drawn to measure inflammatory parameters (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α] and interleukin-10 [IL-10]) and circulating hormones (luteinizing hormone [LH], total testosterone, estradiol, sex hormone-binding globulin [SHBG] and free androgen index [FAI]).
EMA showed a better anti-inflammatory status than MAC (higher IL-10 and IL-10/IL-6 ratio and lower IL-6), but a lower anti-inflammatory status than YC (higher TNF-α) (p < 0.05). The MAC group had lower testosterone levels compared to the YC and EMA group (p < 0.05), and lower estradiol levels and testosterone/LH ratio compared to YC (p < 0.05). In the control groups (MAC and YC), testosterone correlated negatively with age and proinflammatory parameters, and positively with anti-inflammatory parameters.
Elite master athletics elevated levels of anti-inflammatory cytokines above that seen in non-athlete peers and mitigated the age-related reduction in testosterone levels.
•Physical exercise mitigates the effects of biological aging.•Healthy lifestyle mitigates the reduction of androgen hormones.•High levels of testosterone indicate higher anti-inflammatory cytokines.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>34022273</pmid><doi>10.1016/j.exger.2021.111407</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Athletes Biomarkers Exercise Hormonal profile Humans Hypogonadism Inflammation Male Master athletes Middle Aged Older athletes Sex Hormone-Binding Globulin Testosterone |
| title | Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes |
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