Disruption of Circadian Clocks Promotes Progression of Alzheimer’s Disease in Diabetic Mice

The circadian clock is an endogenous system designed to anticipate and adapt to daily changes in the environment. Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is more prevalent in patients with type 2 diabetes mellitus (T2DM). However, the effects of circadian disruptio...

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Veröffentlicht in:	Molecular neurobiology 2021-09, Vol.58 (9), p.4404-4412
Hauptverfasser:	Huang, Jiaojiao, Peng, Xuemin, Fan, Rongping, Dong, Kun, Shi, Xiaoli, Zhang, Shujun, Yu, Xuefeng, Yang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - physiopathology Alzheimer's disease Amyloid Animals Behavior, Animal - physiology Biomedical and Life Sciences Biomedicine Body weight Body weight gain Cell Biology Circadian Clocks - physiology Circadian rhythm Circadian rhythms Cognitive ability Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - physiopathology Disease Models, Animal Disease Progression Gene expression Hippocampus Maze Learning - physiology Mice Motor Activity - physiology Neurobiology Neurodegenerative diseases Neurology Neurosciences Oscillations Phosphorylation Photoperiod Proteins Recognition, Psychology - physiology Rodents Tau protein
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