Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates
Atrial fibrillation (AF) is associated with a fivefold risk of stroke and thrombotic embolism, which are usually derived from the left atrial appendage (LAA). Spontaneous echo contrast (SEC) is known as a risk factor for thrombosis. Porphyromonas gingivalis ( P. gingivalis ) has some prothrombotic e...
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| Veröffentlicht in: | Heart and vessels 2021-11, Vol.36 (11), p.1721-1729 |
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| creator | Miyauchi, Shunsuke Tokuyama, Takehito Shintani, Tomoaki Uotani, Yukimi Miyamoto, Shogo Ikeuchi, Yoshihiro Okamura, Sho Okubo, Yousaku Miyauchi, Mutsumi Nakano, Yukiko |
| description | Atrial fibrillation (AF) is associated with a fivefold risk of stroke and thrombotic embolism, which are usually derived from the left atrial appendage (LAA). Spontaneous echo contrast (SEC) is known as a risk factor for thrombosis.
Porphyromonas gingivalis
(
P.
gingivalis
) has some prothrombotic effects and plays a key role in periodontitis and oral-systemic disease connection. We aimed to clarify the relationship between
P. gingivalis
and LAA SEC among AF patients. A total of 569 AF ablation candidates were enrolled in the present study. LAA SEC was categorized into nondense SEC and dense SEC based on transesophageal echocardiography. Serum immunoglobulin G antibody titers of
P. gingivalis
fimA subtypes (types I–IV) were measured with an enzyme-linked immunosorbent assay. The levels of antibody titers were categorized into high (> mean + 3 standard deviation) and low values. A total of 513 (90%) patients were included in the nondense SEC group, and 56 (10%) were included in the dense SEC group. Multivariate regression analysis revealed that the high-value serum antibody titers of
P. gingivalis
types II and IV were independently associated with dense SEC [type II: adjusted odds ratio (OR) 2.220; 95% confidence interval (CI) 1.062–4.643;
P
= 0.02; and type IV: adjusted OR 3.169; 95% CI 1.058–6.657;
P
= 0.002]. The results revealed that
P. gingivalis
types II and IV are related to LAA SEC severity among AF patients who receive appropriate anticoagulation therapy. |
| doi_str_mv | 10.1007/s00380-021-01851-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2531218098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577749516</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-7e231716e10109e7c421393c01f94989563a9a9e81223728e716f8a9f6aa083</originalsourceid><addsrcrecordid>eNp9kUtvFDEQhC0EIkvgD3BAlrhwGei2Z8b2EUU8IkUCCe5W72zPxtGsPdizrPLvcbIbkHLg5NdX1SWXEK8R3iOA-VAAtIUGFDaAtsPm8ESssMeuUZ3RT8UKHEJjtTJn4kUpNwDYOXTPxZluq0hbvRKH7ynP17c57VKkIrchbsNvmkKRFDdy4nGRtORAk6R55rihLcsyp7hQ5LQvkofrJId6zlQWGeIDPYZ1DtNES0j1bn3aDNU0bGjh8lI8G2kq_Oq0nosfnz_9vPjaXH37cnnx8aoZ2r5bGsNKo8GeERAcm6GtuZ0eAEfXOuu6XpMjxxaV0kZZruxoyY09EVh9Lt4dXeecfu25LH4XysA11316rzqNCi24O_TtI_Qm7XOs2SpljGldh32l1JEaciol8-jnHHaUbz2CvyvFH0vx9X_9fSn-UEVvTtb79Y43fyUPLVRAH4FSn-KW87_Z_7H9Az1AmLQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2577749516</pqid></control><display><type>article</type><title>Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Miyauchi, Shunsuke ; Tokuyama, Takehito ; Shintani, Tomoaki ; Uotani, Yukimi ; Miyamoto, Shogo ; Ikeuchi, Yoshihiro ; Okamura, Sho ; Okubo, Yousaku ; Miyauchi, Mutsumi ; Nakano, Yukiko</creator><creatorcontrib>Miyauchi, Shunsuke ; Tokuyama, Takehito ; Shintani, Tomoaki ; Uotani, Yukimi ; Miyamoto, Shogo ; Ikeuchi, Yoshihiro ; Okamura, Sho ; Okubo, Yousaku ; Miyauchi, Mutsumi ; Nakano, Yukiko</creatorcontrib><description>Atrial fibrillation (AF) is associated with a fivefold risk of stroke and thrombotic embolism, which are usually derived from the left atrial appendage (LAA). Spontaneous echo contrast (SEC) is known as a risk factor for thrombosis.
Porphyromonas gingivalis
(
P.
gingivalis
) has some prothrombotic effects and plays a key role in periodontitis and oral-systemic disease connection. We aimed to clarify the relationship between
P. gingivalis
and LAA SEC among AF patients. A total of 569 AF ablation candidates were enrolled in the present study. LAA SEC was categorized into nondense SEC and dense SEC based on transesophageal echocardiography. Serum immunoglobulin G antibody titers of
P. gingivalis
fimA subtypes (types I–IV) were measured with an enzyme-linked immunosorbent assay. The levels of antibody titers were categorized into high (> mean + 3 standard deviation) and low values. A total of 513 (90%) patients were included in the nondense SEC group, and 56 (10%) were included in the dense SEC group. Multivariate regression analysis revealed that the high-value serum antibody titers of
P. gingivalis
types II and IV were independently associated with dense SEC [type II: adjusted odds ratio (OR) 2.220; 95% confidence interval (CI) 1.062–4.643;
P
= 0.02; and type IV: adjusted OR 3.169; 95% CI 1.058–6.657;
P
= 0.002]. The results revealed that
P. gingivalis
types II and IV are related to LAA SEC severity among AF patients who receive appropriate anticoagulation therapy.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-021-01851-w</identifier><identifier>PMID: 34021383</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Ablation ; Antibodies ; Anticoagulants ; Atrial Appendage - diagnostic imaging ; Atrial Fibrillation - complications ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - surgery ; Biomedical Engineering and Bioengineering ; Cardiac arrhythmia ; Cardiac Surgery ; Cardiology ; Catheter Ablation ; Confidence intervals ; Echocardiography ; Echocardiography, Transesophageal ; Embolism ; Enzyme-linked immunosorbent assay ; Fibrillation ; Gum disease ; Health risks ; Humans ; IgG antibody ; Immunoglobulin G ; Medicine ; Medicine & Public Health ; Original Article ; Periodontitis ; Porphyromonas gingivalis ; Regression analysis ; Risk analysis ; Risk factors ; Statistical analysis ; Thromboembolism ; Thrombosis ; Vascular Surgery</subject><ispartof>Heart and vessels, 2021-11, Vol.36 (11), p.1721-1729</ispartof><rights>Springer Japan KK, part of Springer Nature 2021</rights><rights>2021. Springer Japan KK, part of Springer Nature.</rights><rights>Springer Japan KK, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-7e231716e10109e7c421393c01f94989563a9a9e81223728e716f8a9f6aa083</citedby><cites>FETCH-LOGICAL-c465t-7e231716e10109e7c421393c01f94989563a9a9e81223728e716f8a9f6aa083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-021-01851-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-021-01851-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34021383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyauchi, Shunsuke</creatorcontrib><creatorcontrib>Tokuyama, Takehito</creatorcontrib><creatorcontrib>Shintani, Tomoaki</creatorcontrib><creatorcontrib>Uotani, Yukimi</creatorcontrib><creatorcontrib>Miyamoto, Shogo</creatorcontrib><creatorcontrib>Ikeuchi, Yoshihiro</creatorcontrib><creatorcontrib>Okamura, Sho</creatorcontrib><creatorcontrib>Okubo, Yousaku</creatorcontrib><creatorcontrib>Miyauchi, Mutsumi</creatorcontrib><creatorcontrib>Nakano, Yukiko</creatorcontrib><title>Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>Atrial fibrillation (AF) is associated with a fivefold risk of stroke and thrombotic embolism, which are usually derived from the left atrial appendage (LAA). Spontaneous echo contrast (SEC) is known as a risk factor for thrombosis.
Porphyromonas gingivalis
(
P.
gingivalis
) has some prothrombotic effects and plays a key role in periodontitis and oral-systemic disease connection. We aimed to clarify the relationship between
P. gingivalis
and LAA SEC among AF patients. A total of 569 AF ablation candidates were enrolled in the present study. LAA SEC was categorized into nondense SEC and dense SEC based on transesophageal echocardiography. Serum immunoglobulin G antibody titers of
P. gingivalis
fimA subtypes (types I–IV) were measured with an enzyme-linked immunosorbent assay. The levels of antibody titers were categorized into high (> mean + 3 standard deviation) and low values. A total of 513 (90%) patients were included in the nondense SEC group, and 56 (10%) were included in the dense SEC group. Multivariate regression analysis revealed that the high-value serum antibody titers of
P. gingivalis
types II and IV were independently associated with dense SEC [type II: adjusted odds ratio (OR) 2.220; 95% confidence interval (CI) 1.062–4.643;
P
= 0.02; and type IV: adjusted OR 3.169; 95% CI 1.058–6.657;
P
= 0.002]. The results revealed that
P. gingivalis
types II and IV are related to LAA SEC severity among AF patients who receive appropriate anticoagulation therapy.</description><subject>Ablation</subject><subject>Antibodies</subject><subject>Anticoagulants</subject><subject>Atrial Appendage - diagnostic imaging</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - surgery</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Catheter Ablation</subject><subject>Confidence intervals</subject><subject>Echocardiography</subject><subject>Echocardiography, Transesophageal</subject><subject>Embolism</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Fibrillation</subject><subject>Gum disease</subject><subject>Health risks</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>Immunoglobulin G</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Periodontitis</subject><subject>Porphyromonas gingivalis</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtvFDEQhC0EIkvgD3BAlrhwGei2Z8b2EUU8IkUCCe5W72zPxtGsPdizrPLvcbIbkHLg5NdX1SWXEK8R3iOA-VAAtIUGFDaAtsPm8ESssMeuUZ3RT8UKHEJjtTJn4kUpNwDYOXTPxZluq0hbvRKH7ynP17c57VKkIrchbsNvmkKRFDdy4nGRtORAk6R55rihLcsyp7hQ5LQvkofrJId6zlQWGeIDPYZ1DtNES0j1bn3aDNU0bGjh8lI8G2kq_Oq0nosfnz_9vPjaXH37cnnx8aoZ2r5bGsNKo8GeERAcm6GtuZ0eAEfXOuu6XpMjxxaV0kZZruxoyY09EVh9Lt4dXeecfu25LH4XysA11316rzqNCi24O_TtI_Qm7XOs2SpljGldh32l1JEaciol8-jnHHaUbz2CvyvFH0vx9X_9fSn-UEVvTtb79Y43fyUPLVRAH4FSn-KW87_Z_7H9Az1AmLQ</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Miyauchi, Shunsuke</creator><creator>Tokuyama, Takehito</creator><creator>Shintani, Tomoaki</creator><creator>Uotani, Yukimi</creator><creator>Miyamoto, Shogo</creator><creator>Ikeuchi, Yoshihiro</creator><creator>Okamura, Sho</creator><creator>Okubo, Yousaku</creator><creator>Miyauchi, Mutsumi</creator><creator>Nakano, Yukiko</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20211101</creationdate><title>Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates</title><author>Miyauchi, Shunsuke ; Tokuyama, Takehito ; Shintani, Tomoaki ; Uotani, Yukimi ; Miyamoto, Shogo ; Ikeuchi, Yoshihiro ; Okamura, Sho ; Okubo, Yousaku ; Miyauchi, Mutsumi ; Nakano, Yukiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-7e231716e10109e7c421393c01f94989563a9a9e81223728e716f8a9f6aa083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ablation</topic><topic>Antibodies</topic><topic>Anticoagulants</topic><topic>Atrial Appendage - diagnostic imaging</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - surgery</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Catheter Ablation</topic><topic>Confidence intervals</topic><topic>Echocardiography</topic><topic>Echocardiography, Transesophageal</topic><topic>Embolism</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Fibrillation</topic><topic>Gum disease</topic><topic>Health risks</topic><topic>Humans</topic><topic>IgG antibody</topic><topic>Immunoglobulin G</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Periodontitis</topic><topic>Porphyromonas gingivalis</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Statistical analysis</topic><topic>Thromboembolism</topic><topic>Thrombosis</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyauchi, Shunsuke</creatorcontrib><creatorcontrib>Tokuyama, Takehito</creatorcontrib><creatorcontrib>Shintani, Tomoaki</creatorcontrib><creatorcontrib>Uotani, Yukimi</creatorcontrib><creatorcontrib>Miyamoto, Shogo</creatorcontrib><creatorcontrib>Ikeuchi, Yoshihiro</creatorcontrib><creatorcontrib>Okamura, Sho</creatorcontrib><creatorcontrib>Okubo, Yousaku</creatorcontrib><creatorcontrib>Miyauchi, Mutsumi</creatorcontrib><creatorcontrib>Nakano, Yukiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyauchi, Shunsuke</au><au>Tokuyama, Takehito</au><au>Shintani, Tomoaki</au><au>Uotani, Yukimi</au><au>Miyamoto, Shogo</au><au>Ikeuchi, Yoshihiro</au><au>Okamura, Sho</au><au>Okubo, Yousaku</au><au>Miyauchi, Mutsumi</au><au>Nakano, Yukiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>36</volume><issue>11</issue><spage>1721</spage><epage>1729</epage><pages>1721-1729</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>Atrial fibrillation (AF) is associated with a fivefold risk of stroke and thrombotic embolism, which are usually derived from the left atrial appendage (LAA). Spontaneous echo contrast (SEC) is known as a risk factor for thrombosis.
Porphyromonas gingivalis
(
P.
gingivalis
) has some prothrombotic effects and plays a key role in periodontitis and oral-systemic disease connection. We aimed to clarify the relationship between
P. gingivalis
and LAA SEC among AF patients. A total of 569 AF ablation candidates were enrolled in the present study. LAA SEC was categorized into nondense SEC and dense SEC based on transesophageal echocardiography. Serum immunoglobulin G antibody titers of
P. gingivalis
fimA subtypes (types I–IV) were measured with an enzyme-linked immunosorbent assay. The levels of antibody titers were categorized into high (> mean + 3 standard deviation) and low values. A total of 513 (90%) patients were included in the nondense SEC group, and 56 (10%) were included in the dense SEC group. Multivariate regression analysis revealed that the high-value serum antibody titers of
P. gingivalis
types II and IV were independently associated with dense SEC [type II: adjusted odds ratio (OR) 2.220; 95% confidence interval (CI) 1.062–4.643;
P
= 0.02; and type IV: adjusted OR 3.169; 95% CI 1.058–6.657;
P
= 0.002]. The results revealed that
P. gingivalis
types II and IV are related to LAA SEC severity among AF patients who receive appropriate anticoagulation therapy.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>34021383</pmid><doi>10.1007/s00380-021-01851-w</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Ablation Antibodies Anticoagulants Atrial Appendage - diagnostic imaging Atrial Fibrillation - complications Atrial Fibrillation - diagnosis Atrial Fibrillation - surgery Biomedical Engineering and Bioengineering Cardiac arrhythmia Cardiac Surgery Cardiology Catheter Ablation Confidence intervals Echocardiography Echocardiography, Transesophageal Embolism Enzyme-linked immunosorbent assay Fibrillation Gum disease Health risks Humans IgG antibody Immunoglobulin G Medicine Medicine & Public Health Original Article Periodontitis Porphyromonas gingivalis Regression analysis Risk analysis Risk factors Statistical analysis Thromboembolism Thrombosis Vascular Surgery |
| title | Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates |
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