Treatment with hypoxia‐mimetics protects cultured rat Schwann cells against oxidative stress‐induced cell death

Schwann cell (SC) grafts promote axon regeneration in the injured spinal cord, but transplant efficacy is diminished by a high death rate in the first 2–3 days postimplantation. Both hypoxic preconditioning and pharmacological induction of the cellular hypoxic response can drive cellular adaptations...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Glia 2021-09, Vol.69 (9), p.2215-2234
Hauptverfasser:	David, Brian T., Curtin, Jessica J., Brown, Jennifer L., Coutts, David J. C., Boles, Nathan C., Hill, Caitlin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptaquin Adaptation Animals Axons - metabolism Binding sites Cell Death Cell Hypoxia cell survival Deferoxamine Demyelinating diseases Demyelination Gene expression H2O2 Hypoxia hypoxia adaptations hypoxia inducible factor (HIF) Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Injuries Mortality Nerve Regeneration Oxidative Stress Peripheral Nervous System Diseases - metabolism Pharmacology Preconditioning prolyl hydroxylase inhibition Rats Regeneration reporter assay Schwann cells Schwann Cells - metabolism Spinal cord injuries Survival
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!