Identification and genomic characterization of emerging CRESS DNA viruses in thoroughbred horses in China
Multiple novel circular replication-associated protein (Rep)-encoding single stranded (CRESS) DNA viruses have been extensively identified in the feces of humans and animals. Here, we first detected CRESS DNA virus (named Horse-CRESS DNA-like virus, HCLV) in two fecal samples from 10 imported thorou...
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| description | Multiple novel circular replication-associated protein (Rep)-encoding single stranded (CRESS) DNA viruses have been extensively identified in the feces of humans and animals. Here, we first detected CRESS DNA virus (named Horse-CRESS DNA-like virus, HCLV) in two fecal samples from 10 imported thoroughbred (TB) horses in the customs quarantine station in North Xinjiang province, China. Additionally, we found that this virus was not detected in local breeds (LBs) (0/41) and was found only in imported TB horses (2/73). We obtained the whole-genome sequences of four viruses (HCLV ALSK-3-4, ALSK-13-10, CJ-1-2, and CJ-13-1). Unlike
Circovirus
and
Cyclovirus
, whose genome sequences have 1700 to 2100 nucleotides (nt), these HCLVs have circular genome with 3503, 3504, 3485, 3491 nt, respectively and five major ORFs. The ORF1 gene encodes the Rep protein in HCLVs. Furthermore, the Rep protein of the four HCLVs share 23.3–84.8%, 21.6–27.4%, 23.7–27.2% amino acid identity with the corresponding reference viruses of Kirkoviruses, genus
Circovirus
, and genus
Cyclovirus
, respectively. Moreover, RCR domain, P-loop NTPase domains, and nonanucleotide motif (TAGTATTAC) of the HCLVs are similar to
Circovirus
and
Cyclovirus
. Phylogenetic analysis showed that the virus was grouped together with members in Kirkoviruses. These results suggest the HCLV probably entered Xinjiang province via the international trade of horses. |
| doi_str_mv | 10.1007/s11262-021-01845-w |
| format | Article |
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Circovirus
and
Cyclovirus
, whose genome sequences have 1700 to 2100 nucleotides (nt), these HCLVs have circular genome with 3503, 3504, 3485, 3491 nt, respectively and five major ORFs. The ORF1 gene encodes the Rep protein in HCLVs. Furthermore, the Rep protein of the four HCLVs share 23.3–84.8%, 21.6–27.4%, 23.7–27.2% amino acid identity with the corresponding reference viruses of Kirkoviruses, genus
Circovirus
, and genus
Cyclovirus
, respectively. Moreover, RCR domain, P-loop NTPase domains, and nonanucleotide motif (TAGTATTAC) of the HCLVs are similar to
Circovirus
and
Cyclovirus
. Phylogenetic analysis showed that the virus was grouped together with members in Kirkoviruses. These results suggest the HCLV probably entered Xinjiang province via the international trade of horses.</description><identifier>ISSN: 0920-8569</identifier><identifier>EISSN: 1572-994X</identifier><identifier>DOI: 10.1007/s11262-021-01845-w</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amino acids ; Biomedical and Life Sciences ; Biomedicine ; Deoxyribonucleic acid ; DNA ; DNA viruses ; Genomes ; Medical Microbiology ; Orf1 gene ; Phylogeny ; Plant Sciences ; Proteins ; Rep protein ; Short Report ; Virology ; Viruses</subject><ispartof>Virus genes, 2021-08, Vol.57 (4), p.390-394</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-a480e3b064d082e7dbe0ee6633e82b16d69d0b49d14cdacf03e04921cfec3dd73</citedby><cites>FETCH-LOGICAL-c352t-a480e3b064d082e7dbe0ee6633e82b16d69d0b49d14cdacf03e04921cfec3dd73</cites><orcidid>0000-0003-4772-7162</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11262-021-01845-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11262-021-01845-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Tong, Panpan</creatorcontrib><creatorcontrib>Ren, Meiling</creatorcontrib><creatorcontrib>Xu, Xinlong</creatorcontrib><creatorcontrib>Song, Xiaozhen</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Kuang, Ling</creatorcontrib><creatorcontrib>Xie, Jinxin</creatorcontrib><title>Identification and genomic characterization of emerging CRESS DNA viruses in thoroughbred horses in China</title><title>Virus genes</title><addtitle>Virus Genes</addtitle><description>Multiple novel circular replication-associated protein (Rep)-encoding single stranded (CRESS) DNA viruses have been extensively identified in the feces of humans and animals. Here, we first detected CRESS DNA virus (named Horse-CRESS DNA-like virus, HCLV) in two fecal samples from 10 imported thoroughbred (TB) horses in the customs quarantine station in North Xinjiang province, China. Additionally, we found that this virus was not detected in local breeds (LBs) (0/41) and was found only in imported TB horses (2/73). We obtained the whole-genome sequences of four viruses (HCLV ALSK-3-4, ALSK-13-10, CJ-1-2, and CJ-13-1). Unlike
Circovirus
and
Cyclovirus
, whose genome sequences have 1700 to 2100 nucleotides (nt), these HCLVs have circular genome with 3503, 3504, 3485, 3491 nt, respectively and five major ORFs. The ORF1 gene encodes the Rep protein in HCLVs. Furthermore, the Rep protein of the four HCLVs share 23.3–84.8%, 21.6–27.4%, 23.7–27.2% amino acid identity with the corresponding reference viruses of Kirkoviruses, genus
Circovirus
, and genus
Cyclovirus
, respectively. Moreover, RCR domain, P-loop NTPase domains, and nonanucleotide motif (TAGTATTAC) of the HCLVs are similar to
Circovirus
and
Cyclovirus
. Phylogenetic analysis showed that the virus was grouped together with members in Kirkoviruses. These results suggest the HCLV probably entered Xinjiang province via the international trade of horses.</description><subject>Amino acids</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA viruses</subject><subject>Genomes</subject><subject>Medical Microbiology</subject><subject>Orf1 gene</subject><subject>Phylogeny</subject><subject>Plant Sciences</subject><subject>Proteins</subject><subject>Rep protein</subject><subject>Short Report</subject><subject>Virology</subject><subject>Viruses</subject><issn>0920-8569</issn><issn>1572-994X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kMtLJDEQh8OisLO6_8CeAl68tFt59CNHmfUxIAo-wFtIJ9U9kZnETbpX9K-3Z1tY2IOnKqq-X1F8hPxgcMIA6p-ZMV7xAjgrgDWyLF6-kAUra14oJR_3yAIUh6IpK_WVfMv5CQCahssF8SuHYfCdt2bwMVATHO0xxK231K5NMnbA5N_mZewobjH1PvR0eXt2d0d_XZ_SPz6NGTP1gQ7rmOLYr9uEjk79x3i59sEckv3ObDJ-_6gH5OH87H55WVzdXKyWp1eFFSUfCiMbQNFCJR00HGvXIiBWlRDY8JZVrlIOWqkck9YZ24FAkIoz26EVztXigBzPd59T_D1iHvTWZ4ubjQkYx6x5KRhnUskdevQf-hTHFKbvJmpH1LxUE8VnyqaYc8JOPye_NelVM9A7-3q2ryf7-q99_TKFxBzKExx6TP9Of5J6B9v6iSU</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Tong, Panpan</creator><creator>Ren, Meiling</creator><creator>Xu, Xinlong</creator><creator>Song, Xiaozhen</creator><creator>Zhang, Lei</creator><creator>Kuang, Ling</creator><creator>Xie, Jinxin</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4772-7162</orcidid></search><sort><creationdate>20210801</creationdate><title>Identification and genomic characterization of emerging CRESS DNA viruses in thoroughbred horses in China</title><author>Tong, Panpan ; Ren, Meiling ; Xu, Xinlong ; Song, Xiaozhen ; Zhang, Lei ; Kuang, Ling ; Xie, Jinxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-a480e3b064d082e7dbe0ee6633e82b16d69d0b49d14cdacf03e04921cfec3dd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amino acids</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA viruses</topic><topic>Genomes</topic><topic>Medical Microbiology</topic><topic>Orf1 gene</topic><topic>Phylogeny</topic><topic>Plant Sciences</topic><topic>Proteins</topic><topic>Rep protein</topic><topic>Short Report</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tong, Panpan</creatorcontrib><creatorcontrib>Ren, Meiling</creatorcontrib><creatorcontrib>Xu, Xinlong</creatorcontrib><creatorcontrib>Song, Xiaozhen</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Kuang, Ling</creatorcontrib><creatorcontrib>Xie, Jinxin</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virus genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tong, Panpan</au><au>Ren, Meiling</au><au>Xu, Xinlong</au><au>Song, Xiaozhen</au><au>Zhang, Lei</au><au>Kuang, Ling</au><au>Xie, Jinxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification and genomic characterization of emerging CRESS DNA viruses in thoroughbred horses in China</atitle><jtitle>Virus genes</jtitle><stitle>Virus Genes</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>57</volume><issue>4</issue><spage>390</spage><epage>394</epage><pages>390-394</pages><issn>0920-8569</issn><eissn>1572-994X</eissn><abstract>Multiple novel circular replication-associated protein (Rep)-encoding single stranded (CRESS) DNA viruses have been extensively identified in the feces of humans and animals. Here, we first detected CRESS DNA virus (named Horse-CRESS DNA-like virus, HCLV) in two fecal samples from 10 imported thoroughbred (TB) horses in the customs quarantine station in North Xinjiang province, China. Additionally, we found that this virus was not detected in local breeds (LBs) (0/41) and was found only in imported TB horses (2/73). We obtained the whole-genome sequences of four viruses (HCLV ALSK-3-4, ALSK-13-10, CJ-1-2, and CJ-13-1). Unlike
Circovirus
and
Cyclovirus
, whose genome sequences have 1700 to 2100 nucleotides (nt), these HCLVs have circular genome with 3503, 3504, 3485, 3491 nt, respectively and five major ORFs. The ORF1 gene encodes the Rep protein in HCLVs. Furthermore, the Rep protein of the four HCLVs share 23.3–84.8%, 21.6–27.4%, 23.7–27.2% amino acid identity with the corresponding reference viruses of Kirkoviruses, genus
Circovirus
, and genus
Cyclovirus
, respectively. Moreover, RCR domain, P-loop NTPase domains, and nonanucleotide motif (TAGTATTAC) of the HCLVs are similar to
Circovirus
and
Cyclovirus
. Phylogenetic analysis showed that the virus was grouped together with members in Kirkoviruses. These results suggest the HCLV probably entered Xinjiang province via the international trade of horses.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11262-021-01845-w</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4772-7162</orcidid></addata></record> |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Amino acids Biomedical and Life Sciences Biomedicine Deoxyribonucleic acid DNA DNA viruses Genomes Medical Microbiology Orf1 gene Phylogeny Plant Sciences Proteins Rep protein Short Report Virology Viruses |
| title | Identification and genomic characterization of emerging CRESS DNA viruses in thoroughbred horses in China |
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