Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo
Background Taurine‐upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA‐377 (miRNA‐377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator‐activated receptors (PPARs) are compon...
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| Veröffentlicht in: | International journal of dermatology 2022-02, Vol.61 (2), p.199-207 |
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| creator | Alhelf, Maha Rashed, Laila A. Ragab, Noura Elmasry, Maha F. |
| description | Background
Taurine‐upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA‐377 (miRNA‐377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator‐activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR‐γ activators stimulate melanogenesis. Interleukin (IL)‐17 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA‐377, PPAR‐γ, and IL‐17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo.
Methods
This study was conducted on 30 healthy controls and 30 vitiligo patients. LncRNA TUG1 and miRNA‐377 were detected in serum by real‐time polymerase chain reaction (PCR). Also, expressions of PPAR‐γ and IL‐17 were assessed in tissue by real‐time PCR.
Results
LncRNA TUG1 and PPAR‐γ levels were significantly downregulated in the vitiligo group compared with the control group. On the other hand, miRNA‐377 and IL‐17 were significantly upregulated in the vitiligo group compared with the control group.
Conclusion
This study demonstrated the dysregulated expressions of lncRNA TUG1 and miRNA‐377 in patients with vitiligo suggesting that both contributed to the pathogenesis of vitiligo that might be through PPAR‐γ downregulation and IL‐17 upregulation. |
| doi_str_mv | 10.1111/ijd.15669 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2529914498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2529914498</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-8c39b456ea186eaf6d493e6cf1e643769c877fc79ff12d3d532391ddee49e7073</originalsourceid><addsrcrecordid>eNp10MtO3DAUBmCroupMgUVfoLLEhi7C5MSOHS9H0MtUI5AQrK3EPok8ytjTOAGx6yPwjDxJTQdYVKoXvkiffh3_hHyC_AzSWriNPYNSCPWOzIGJMuOCFQdknucAmcpLNSMfY9ykJyuAfyAzxnPgpajmpFnGGIyrRxc8bXC8R_S0D76jPngTrEu368slHetpcB6ffj9OuwG7qa9HtLRDjxRo7S3dOjOEJJNgUlLn6Z0bXe-6cETet3Uf8fjlPCS3377enP_I1lffV-fLdWZYyVRWGaaaNBTWUKWtFZYrhsK0gIIzKZSppGyNVG0LhWW2ZAVTYC0iVyhzyQ7J6T53N4RfE8ZRb1002Pe1xzBFXZSFUsC5qhI9-YduwjT4NJ0uBFSFZKKCpL7sVfpZjAO2eje4bT08aMj1c_E6Fa__Fp_s55fEqdmifZOvTSew2IN71-PD_5P06ufFPvIPQEqNRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2618273681</pqid></control><display><type>article</type><title>Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Alhelf, Maha ; Rashed, Laila A. ; Ragab, Noura ; Elmasry, Maha F.</creator><creatorcontrib>Alhelf, Maha ; Rashed, Laila A. ; Ragab, Noura ; Elmasry, Maha F.</creatorcontrib><description>Background
Taurine‐upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA‐377 (miRNA‐377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator‐activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR‐γ activators stimulate melanogenesis. Interleukin (IL)‐17 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA‐377, PPAR‐γ, and IL‐17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo.
Methods
This study was conducted on 30 healthy controls and 30 vitiligo patients. LncRNA TUG1 and miRNA‐377 were detected in serum by real‐time polymerase chain reaction (PCR). Also, expressions of PPAR‐γ and IL‐17 were assessed in tissue by real‐time PCR.
Results
LncRNA TUG1 and PPAR‐γ levels were significantly downregulated in the vitiligo group compared with the control group. On the other hand, miRNA‐377 and IL‐17 were significantly upregulated in the vitiligo group compared with the control group.
Conclusion
This study demonstrated the dysregulated expressions of lncRNA TUG1 and miRNA‐377 in patients with vitiligo suggesting that both contributed to the pathogenesis of vitiligo that might be through PPAR‐γ downregulation and IL‐17 upregulation.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.15669</identifier><identifier>PMID: 34014568</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Angiogenesis ; Cell Proliferation ; Down-Regulation ; Humans ; Immunological diseases ; Immunology ; Interleukins ; MicroRNAs ; miRNA ; Non-coding RNA ; Oxidative stress ; Pathogenesis ; Peroxisome proliferator-activated receptors ; Polymerase chain reaction ; Receptors ; Ribonucleic acid ; RNA ; RNA, Long Noncoding ; Skin diseases ; Taurine ; Vitiligo</subject><ispartof>International journal of dermatology, 2022-02, Vol.61 (2), p.199-207</ispartof><rights>2021</rights><rights>2021 the International Society of Dermatology.</rights><rights>International Journal of Dermatology © 2022 International Society of Dermatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-8c39b456ea186eaf6d493e6cf1e643769c877fc79ff12d3d532391ddee49e7073</citedby><cites>FETCH-LOGICAL-c3539-8c39b456ea186eaf6d493e6cf1e643769c877fc79ff12d3d532391ddee49e7073</cites><orcidid>0000-0002-3873-3897</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.15669$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.15669$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34014568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alhelf, Maha</creatorcontrib><creatorcontrib>Rashed, Laila A.</creatorcontrib><creatorcontrib>Ragab, Noura</creatorcontrib><creatorcontrib>Elmasry, Maha F.</creatorcontrib><title>Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Taurine‐upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA‐377 (miRNA‐377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator‐activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR‐γ activators stimulate melanogenesis. Interleukin (IL)‐17 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA‐377, PPAR‐γ, and IL‐17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo.
Methods
This study was conducted on 30 healthy controls and 30 vitiligo patients. LncRNA TUG1 and miRNA‐377 were detected in serum by real‐time polymerase chain reaction (PCR). Also, expressions of PPAR‐γ and IL‐17 were assessed in tissue by real‐time PCR.
Results
LncRNA TUG1 and PPAR‐γ levels were significantly downregulated in the vitiligo group compared with the control group. On the other hand, miRNA‐377 and IL‐17 were significantly upregulated in the vitiligo group compared with the control group.
Conclusion
This study demonstrated the dysregulated expressions of lncRNA TUG1 and miRNA‐377 in patients with vitiligo suggesting that both contributed to the pathogenesis of vitiligo that might be through PPAR‐γ downregulation and IL‐17 upregulation.</description><subject>Angiogenesis</subject><subject>Cell Proliferation</subject><subject>Down-Regulation</subject><subject>Humans</subject><subject>Immunological diseases</subject><subject>Immunology</subject><subject>Interleukins</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>Non-coding RNA</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Polymerase chain reaction</subject><subject>Receptors</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding</subject><subject>Skin diseases</subject><subject>Taurine</subject><subject>Vitiligo</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtO3DAUBmCroupMgUVfoLLEhi7C5MSOHS9H0MtUI5AQrK3EPok8ytjTOAGx6yPwjDxJTQdYVKoXvkiffh3_hHyC_AzSWriNPYNSCPWOzIGJMuOCFQdknucAmcpLNSMfY9ykJyuAfyAzxnPgpajmpFnGGIyrRxc8bXC8R_S0D76jPngTrEu368slHetpcB6ffj9OuwG7qa9HtLRDjxRo7S3dOjOEJJNgUlLn6Z0bXe-6cETet3Uf8fjlPCS3377enP_I1lffV-fLdWZYyVRWGaaaNBTWUKWtFZYrhsK0gIIzKZSppGyNVG0LhWW2ZAVTYC0iVyhzyQ7J6T53N4RfE8ZRb1002Pe1xzBFXZSFUsC5qhI9-YduwjT4NJ0uBFSFZKKCpL7sVfpZjAO2eje4bT08aMj1c_E6Fa__Fp_s55fEqdmifZOvTSew2IN71-PD_5P06ufFPvIPQEqNRA</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Alhelf, Maha</creator><creator>Rashed, Laila A.</creator><creator>Ragab, Noura</creator><creator>Elmasry, Maha F.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3873-3897</orcidid></search><sort><creationdate>202202</creationdate><title>Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo</title><author>Alhelf, Maha ; Rashed, Laila A. ; Ragab, Noura ; Elmasry, Maha F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-8c39b456ea186eaf6d493e6cf1e643769c877fc79ff12d3d532391ddee49e7073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiogenesis</topic><topic>Cell Proliferation</topic><topic>Down-Regulation</topic><topic>Humans</topic><topic>Immunological diseases</topic><topic>Immunology</topic><topic>Interleukins</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>Non-coding RNA</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Peroxisome proliferator-activated receptors</topic><topic>Polymerase chain reaction</topic><topic>Receptors</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding</topic><topic>Skin diseases</topic><topic>Taurine</topic><topic>Vitiligo</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alhelf, Maha</creatorcontrib><creatorcontrib>Rashed, Laila A.</creatorcontrib><creatorcontrib>Ragab, Noura</creatorcontrib><creatorcontrib>Elmasry, Maha F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alhelf, Maha</au><au>Rashed, Laila A.</au><au>Ragab, Noura</au><au>Elmasry, Maha F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2022-02</date><risdate>2022</risdate><volume>61</volume><issue>2</issue><spage>199</spage><epage>207</epage><pages>199-207</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Taurine‐upregulated gene 1 (TUG1) is one of the long noncoding RNAs (lncRNAs) that plays a role in melanogenesis. MicroRNA‐377 (miRNA‐377) is a conserved noncoding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator‐activated receptors (PPARs) are components of the nuclear hormone receptor superfamily. PPAR‐γ activators stimulate melanogenesis. Interleukin (IL)‐17 has been implicated in the pathogenesis of several immunological diseases. This work aimed at detecting the expression levels of lncRNA TUG1, miRNA‐377, PPAR‐γ, and IL‐17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo.
Methods
This study was conducted on 30 healthy controls and 30 vitiligo patients. LncRNA TUG1 and miRNA‐377 were detected in serum by real‐time polymerase chain reaction (PCR). Also, expressions of PPAR‐γ and IL‐17 were assessed in tissue by real‐time PCR.
Results
LncRNA TUG1 and PPAR‐γ levels were significantly downregulated in the vitiligo group compared with the control group. On the other hand, miRNA‐377 and IL‐17 were significantly upregulated in the vitiligo group compared with the control group.
Conclusion
This study demonstrated the dysregulated expressions of lncRNA TUG1 and miRNA‐377 in patients with vitiligo suggesting that both contributed to the pathogenesis of vitiligo that might be through PPAR‐γ downregulation and IL‐17 upregulation.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>34014568</pmid><doi>10.1111/ijd.15669</doi><tpages>207</tpages><orcidid>https://orcid.org/0000-0002-3873-3897</orcidid></addata></record> |
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| ispartof | International journal of dermatology, 2022-02, Vol.61 (2), p.199-207 |
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| subjects | Angiogenesis Cell Proliferation Down-Regulation Humans Immunological diseases Immunology Interleukins MicroRNAs miRNA Non-coding RNA Oxidative stress Pathogenesis Peroxisome proliferator-activated receptors Polymerase chain reaction Receptors Ribonucleic acid RNA RNA, Long Noncoding Skin diseases Taurine Vitiligo |
| title | Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo |
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