Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age
Infant neurodevelopment is a complex process which may be affected by different events during pregnancy, such as hypertensive disorders of pregnancy (HDP). We conducted a prospective cohort study to compare the prevalence of neurodevelopmental disorders in infants born to mothers with and without HD...
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| Veröffentlicht in: | Journal of developmental origins of health and disease 2022-04, Vol.13 (2), p.197-203 |
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| container_title | Journal of developmental origins of health and disease |
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| creator | Sala, Marisa E. Romero, M. Florencia Romero, Anabella Fasano, M. Victoria Varea, Ana M. Carrera, Patricia Salazar, Martín R. Espeche, Walter G. González, Horacio F. |
| description | Infant neurodevelopment is a complex process which may be affected by different events during pregnancy, such as hypertensive disorders of pregnancy (HDP). We conducted a prospective cohort study to compare the prevalence of neurodevelopmental disorders in infants born to mothers with and without HDP at six months of age. Participants attended the Health Observatory of Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” during 2018 and 2019. Infant neurodevelopment was assessed with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III). Data were analyzed using Chi-square, Student’s t-test and Mann–Whitney test. Of the 132 participating infants, 68 and 64 were born to mothers with and without HDP, respectively. At six months, the prevalence of risk of neurodevelopmental delay was significantly higher in infants born to mothers with than without HDP (27.9% vs. 9.4%; p = 0.008) (odds ratio, 3.71; 95% confidence interval, 1.30; 12.28). In conclusion, infants born to mothers with HDP had three times increased risk of neurodevelopmental delay at six months of age. |
| doi_str_mv | 10.1017/S204017442100026X |
| format | Article |
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Florencia ; Romero, Anabella ; Fasano, M. Victoria ; Varea, Ana M. ; Carrera, Patricia ; Salazar, Martín R. ; Espeche, Walter G. ; González, Horacio F.</creator><creatorcontrib>Sala, Marisa E. ; Romero, M. Florencia ; Romero, Anabella ; Fasano, M. Victoria ; Varea, Ana M. ; Carrera, Patricia ; Salazar, Martín R. ; Espeche, Walter G. ; González, Horacio F.</creatorcontrib><description>Infant neurodevelopment is a complex process which may be affected by different events during pregnancy, such as hypertensive disorders of pregnancy (HDP). We conducted a prospective cohort study to compare the prevalence of neurodevelopmental disorders in infants born to mothers with and without HDP at six months of age. Participants attended the Health Observatory of Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” during 2018 and 2019. Infant neurodevelopment was assessed with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III). Data were analyzed using Chi-square, Student’s t-test and Mann–Whitney test. Of the 132 participating infants, 68 and 64 were born to mothers with and without HDP, respectively. At six months, the prevalence of risk of neurodevelopmental delay was significantly higher in infants born to mothers with than without HDP (27.9% vs. 9.4%; p = 0.008) (odds ratio, 3.71; 95% confidence interval, 1.30; 12.28). In conclusion, infants born to mothers with HDP had three times increased risk of neurodevelopmental delay at six months of age.</description><identifier>ISSN: 2040-1744</identifier><identifier>EISSN: 2040-1752</identifier><identifier>DOI: 10.1017/S204017442100026X</identifier><identifier>PMID: 34011422</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Age ; Babies ; Body mass index ; Child Development ; Children & youth ; Diabetes ; Female ; Humans ; Hypertension ; Hypertension, Pregnancy-Induced - diagnosis ; Hypertension, Pregnancy-Induced - epidemiology ; Infant ; Mothers ; Nervous system ; Neurodevelopmental disorders ; Neurodevelopmental Disorders - diagnosis ; Neurodevelopmental Disorders - epidemiology ; Neurodevelopmental Disorders - etiology ; Original Article ; Pre-Eclampsia ; Pregnancy ; Pregnancy complications ; Prospective Studies ; Womens health</subject><ispartof>Journal of developmental origins of health and disease, 2022-04, Vol.13 (2), p.197-203</ispartof><rights>The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-bded9c29be602e4edafe8674d0cb700333f9c1fec944a6c529342e68f7ff3eb73</citedby><cites>FETCH-LOGICAL-c373t-bded9c29be602e4edafe8674d0cb700333f9c1fec944a6c529342e68f7ff3eb73</cites><orcidid>0000-0003-4925-7846</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S204017442100026X/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,781,785,27929,27930,55633</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34011422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sala, Marisa E.</creatorcontrib><creatorcontrib>Romero, M. Florencia</creatorcontrib><creatorcontrib>Romero, Anabella</creatorcontrib><creatorcontrib>Fasano, M. Victoria</creatorcontrib><creatorcontrib>Varea, Ana M.</creatorcontrib><creatorcontrib>Carrera, Patricia</creatorcontrib><creatorcontrib>Salazar, Martín R.</creatorcontrib><creatorcontrib>Espeche, Walter G.</creatorcontrib><creatorcontrib>González, Horacio F.</creatorcontrib><title>Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age</title><title>Journal of developmental origins of health and disease</title><addtitle>J Dev Orig Health Dis</addtitle><description>Infant neurodevelopment is a complex process which may be affected by different events during pregnancy, such as hypertensive disorders of pregnancy (HDP). We conducted a prospective cohort study to compare the prevalence of neurodevelopmental disorders in infants born to mothers with and without HDP at six months of age. Participants attended the Health Observatory of Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” during 2018 and 2019. Infant neurodevelopment was assessed with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III). Data were analyzed using Chi-square, Student’s t-test and Mann–Whitney test. Of the 132 participating infants, 68 and 64 were born to mothers with and without HDP, respectively. At six months, the prevalence of risk of neurodevelopmental delay was significantly higher in infants born to mothers with than without HDP (27.9% vs. 9.4%; p = 0.008) (odds ratio, 3.71; 95% confidence interval, 1.30; 12.28). In conclusion, infants born to mothers with HDP had three times increased risk of neurodevelopmental delay at six months of age.</description><subject>Age</subject><subject>Babies</subject><subject>Body mass index</subject><subject>Child Development</subject><subject>Children & youth</subject><subject>Diabetes</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pregnancy-Induced - diagnosis</subject><subject>Hypertension, Pregnancy-Induced - epidemiology</subject><subject>Infant</subject><subject>Mothers</subject><subject>Nervous system</subject><subject>Neurodevelopmental disorders</subject><subject>Neurodevelopmental Disorders - diagnosis</subject><subject>Neurodevelopmental Disorders - epidemiology</subject><subject>Neurodevelopmental Disorders - etiology</subject><subject>Original Article</subject><subject>Pre-Eclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Prospective Studies</subject><subject>Womens health</subject><issn>2040-1744</issn><issn>2040-1752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUtP3DAUhS1ExYwoP4ANstQNmwG_JpksEWoBCdFFW4ld5NjXM0GJHXwdyvz7OmIYpFZdHT_Od_w4hJxydsEZLy9_CKayKiU4Y0wUjwdkPi0teLkUh_uxUjNygviUPUxylZEjMpNZuBJiTsYHGGOw8AJdGHrwSXdUIwLiNKHB0dY77RPSJkRPU6B9SBuISH-3aUM32wFiAo_tC1DbYogW4kQNEdZee7OlOlFsXzPm0wanLb2Gz-ST0x3CyU6Pya9vX39e3y7uv9_cXV_dL4wsZVo0FmxlRNVAwQQosNrBqiiVZaYp83OkdJXhDkyllC7MUlRSCShWrnROQlPKY3L-ljvE8DwCprpv0UDXaQ9hxFpkpOIZm6xf_rI-hTH6fLtaFHJV5Z_kLLv4m8vEgBjB1UNsex23NWf1VEv9Ty2ZOdslj00Pdk-8l5ANcheq-ya2dg0fZ_8_9g99jpj3</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Sala, Marisa E.</creator><creator>Romero, M. 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Victoria</creator><creator>Varea, Ana M.</creator><creator>Carrera, Patricia</creator><creator>Salazar, Martín R.</creator><creator>Espeche, Walter G.</creator><creator>González, Horacio F.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4925-7846</orcidid></search><sort><creationdate>20220401</creationdate><title>Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age</title><author>Sala, Marisa E. ; Romero, M. 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Florencia</au><au>Romero, Anabella</au><au>Fasano, M. Victoria</au><au>Varea, Ana M.</au><au>Carrera, Patricia</au><au>Salazar, Martín R.</au><au>Espeche, Walter G.</au><au>González, Horacio F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age</atitle><jtitle>Journal of developmental origins of health and disease</jtitle><addtitle>J Dev Orig Health Dis</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>13</volume><issue>2</issue><spage>197</spage><epage>203</epage><pages>197-203</pages><issn>2040-1744</issn><eissn>2040-1752</eissn><abstract>Infant neurodevelopment is a complex process which may be affected by different events during pregnancy, such as hypertensive disorders of pregnancy (HDP). We conducted a prospective cohort study to compare the prevalence of neurodevelopmental disorders in infants born to mothers with and without HDP at six months of age. Participants attended the Health Observatory of Instituto de Desarrollo e Investigaciones Pediátricas “Prof. Dr. Fernando E. Viteri” during 2018 and 2019. Infant neurodevelopment was assessed with the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley-III). Data were analyzed using Chi-square, Student’s t-test and Mann–Whitney test. Of the 132 participating infants, 68 and 64 were born to mothers with and without HDP, respectively. At six months, the prevalence of risk of neurodevelopmental delay was significantly higher in infants born to mothers with than without HDP (27.9% vs. 9.4%; p = 0.008) (odds ratio, 3.71; 95% confidence interval, 1.30; 12.28). In conclusion, infants born to mothers with HDP had three times increased risk of neurodevelopmental delay at six months of age.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>34011422</pmid><doi>10.1017/S204017442100026X</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4925-7846</orcidid></addata></record> |
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| ispartof | Journal of developmental origins of health and disease, 2022-04, Vol.13 (2), p.197-203 |
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| source | MEDLINE; Cambridge University Press Journals Complete |
| subjects | Age Babies Body mass index Child Development Children & youth Diabetes Female Humans Hypertension Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - epidemiology Infant Mothers Nervous system Neurodevelopmental disorders Neurodevelopmental Disorders - diagnosis Neurodevelopmental Disorders - epidemiology Neurodevelopmental Disorders - etiology Original Article Pre-Eclampsia Pregnancy Pregnancy complications Prospective Studies Womens health |
| title | Neurodevelopmental assessment of infants born to mothers with hypertensive disorder of pregnancy at six months of age |
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