Delayed Neurological Improvement After Full Endovascular Reperfusion in Acute Anterior Circulation Ischemic Stroke
We aimed to determine the prevalence and predictors of delayed neurological improvement (DNI) after complete endovascular reperfusion in anterior circulation acute ischemic stroke (AIS). Retrospective analysis of an online multicenter prospective reperfusion registry of patients with consecutive ant...
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| Veröffentlicht in: | Stroke (1970) 2021-07, Vol.52 (7), p.2210-2217 |
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| creator | Talavera, Blanca Gómez-Vicente, Beatriz Martínez-Galdámez, Mario López-Cancio, Elena García-Cabo, Carmen Castellanos, Mar Roel, Alexia Tejada-Meza, Herbert Marta-Moreno, Javier Pérez-Lázaro, Cristina Navarro-Pérez, María Pilar Bravo-Anguiano, Yolanda Bártulos-Iglesias, Mónica Tejada-García, Javier Rodrigo-Stevens, Gabriela Martínez-Zabaleta, Maite de la Riva, Patricia Timiraos-Fernández, Juan José del Mar Freijo, María Luna, Alain García-Sánchez, Juan Manuel del Carmen Gil-Alzueta, María Palacio-Portilla, Enrique Jesús Jiménez-López, Yésica López-Mesonero, Luis Redondo-Robles, Laura Mayo-Iscar, Agustín Arenillas, Juan F. |
| description | We aimed to determine the prevalence and predictors of delayed neurological improvement (DNI) after complete endovascular reperfusion in anterior circulation acute ischemic stroke (AIS).
Retrospective analysis of an online multicenter prospective reperfusion registry of patients with consecutive anterior circulation AIS treated with endovascular thrombectomy (EVT) from January 2018 to June 2019 in tertiary stroke centers of the NORDICTUS (NORD-Spain Network for Research and Innovation in ICTUS) network. We included patients with AIS with a proximal occlusion in whom a modified Thrombolysis in Cerebral Infarction 3 reperfusion pattern was obtained. DNI was defined if, despite absence of early neurological improvement during the first 24 hours, patients achieved functional independence on day 90. Clinical and radiological variables obtained before EVT were analyzed as potential predictors of DNI.
Of 1565 patients with consecutive AIS treated with EVT, 1381 had proximal anterior circulation occlusions, 803 (58%) of whom achieved a modified Thrombolysis in Cerebral Infarction 3. Of these, 628 patients fulfilled all selection criteria and were included in the study. Mean age was 73.8 years, 323 (51.4%) were female, and median baseline National Institutes of Health Stroke Scale was 16. Absence of early neurological improvement was observed in 142 (22.6%) patients; 32 of these (22.5%) achieved good long-term outcome and constitute the DNI group. Predictors of DNI in multivariable-adjusted logistic regression were male sex (odds ratio, 6.4 [95% CI, 2.1–22.3] P=0.002), lower pre-EVT National Institutes of Health Stroke Scale score (odds ratio, 1.4 [95% CI, 1.2–1.5], P |
| doi_str_mv | 10.1161/STROKEAHA.120.032066 |
| format | Article |
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Retrospective analysis of an online multicenter prospective reperfusion registry of patients with consecutive anterior circulation AIS treated with endovascular thrombectomy (EVT) from January 2018 to June 2019 in tertiary stroke centers of the NORDICTUS (NORD-Spain Network for Research and Innovation in ICTUS) network. We included patients with AIS with a proximal occlusion in whom a modified Thrombolysis in Cerebral Infarction 3 reperfusion pattern was obtained. DNI was defined if, despite absence of early neurological improvement during the first 24 hours, patients achieved functional independence on day 90. Clinical and radiological variables obtained before EVT were analyzed as potential predictors of DNI.
Of 1565 patients with consecutive AIS treated with EVT, 1381 had proximal anterior circulation occlusions, 803 (58%) of whom achieved a modified Thrombolysis in Cerebral Infarction 3. Of these, 628 patients fulfilled all selection criteria and were included in the study. Mean age was 73.8 years, 323 (51.4%) were female, and median baseline National Institutes of Health Stroke Scale was 16. Absence of early neurological improvement was observed in 142 (22.6%) patients; 32 of these (22.5%) achieved good long-term outcome and constitute the DNI group. Predictors of DNI in multivariable-adjusted logistic regression were male sex (odds ratio, 6.4 [95% CI, 2.1–22.3] P=0.002), lower pre-EVT National Institutes of Health Stroke Scale score (odds ratio, 1.4 [95% CI, 1.2–1.5], P<0.001), and intravenous thrombolysis (odds ratio, 9.1 [95% CI, 2.7–30.90], P<0.001).
One-quarter of patients with anterior circulation AIS who do not clinically improve within the first 24 hours after complete cerebral endovascular recanalization will achieve long-term functional independence, regardless of the poor early clinical course. Male sex, lower initial clinical severity, and use of intravenous thrombolysis before EVT predicted this clinical pattern.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.120.032066</identifier><identifier>PMID: 34011172</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Aged ; Aged, 80 and over ; Brain Ischemia - diagnostic imaging ; Brain Ischemia - surgery ; Cerebral Revascularization - methods ; Cerebral Revascularization - trends ; Endovascular Procedures - methods ; Endovascular Procedures - trends ; Female ; Follow-Up Studies ; Humans ; Ischemic Stroke - diagnostic imaging ; Ischemic Stroke - surgery ; Male ; Middle Aged ; Nervous System Diseases - diagnostic imaging ; Nervous System Diseases - surgery ; Prospective Studies ; Registries ; Retrospective Studies</subject><ispartof>Stroke (1970), 2021-07, Vol.52 (7), p.2210-2217</ispartof><rights>Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3984-e505bbac93d04d9946ccf4a1bd8dc88e14534a4715bb905963b7447f6253ce83</citedby><cites>FETCH-LOGICAL-c3984-e505bbac93d04d9946ccf4a1bd8dc88e14534a4715bb905963b7447f6253ce83</cites><orcidid>0000-0003-0951-6508 ; 0000-0001-5757-9074 ; 0000-0001-6542-868X ; 0000-0001-7444-0074 ; 0000-0002-2019-598X ; 0000-0002-6506-1037 ; 0000-0003-0012-9747 ; 0000-0001-7464-6101 ; 0000-0003-3116-1352 ; 0000-0003-3574-3034 ; 0000-0001-6370-218X ; 0000-0002-8024-4712</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3688,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34011172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Talavera, Blanca</creatorcontrib><creatorcontrib>Gómez-Vicente, Beatriz</creatorcontrib><creatorcontrib>Martínez-Galdámez, Mario</creatorcontrib><creatorcontrib>López-Cancio, Elena</creatorcontrib><creatorcontrib>García-Cabo, Carmen</creatorcontrib><creatorcontrib>Castellanos, Mar</creatorcontrib><creatorcontrib>Roel, Alexia</creatorcontrib><creatorcontrib>Tejada-Meza, Herbert</creatorcontrib><creatorcontrib>Marta-Moreno, Javier</creatorcontrib><creatorcontrib>Pérez-Lázaro, Cristina</creatorcontrib><creatorcontrib>Navarro-Pérez, María Pilar</creatorcontrib><creatorcontrib>Bravo-Anguiano, Yolanda</creatorcontrib><creatorcontrib>Bártulos-Iglesias, Mónica</creatorcontrib><creatorcontrib>Tejada-García, Javier</creatorcontrib><creatorcontrib>Rodrigo-Stevens, Gabriela</creatorcontrib><creatorcontrib>Martínez-Zabaleta, Maite</creatorcontrib><creatorcontrib>de la Riva, Patricia</creatorcontrib><creatorcontrib>Timiraos-Fernández, Juan José</creatorcontrib><creatorcontrib>del Mar Freijo, María</creatorcontrib><creatorcontrib>Luna, Alain</creatorcontrib><creatorcontrib>García-Sánchez, Juan Manuel</creatorcontrib><creatorcontrib>del Carmen Gil-Alzueta, María</creatorcontrib><creatorcontrib>Palacio-Portilla, Enrique Jesús</creatorcontrib><creatorcontrib>Jiménez-López, Yésica</creatorcontrib><creatorcontrib>López-Mesonero, Luis</creatorcontrib><creatorcontrib>Redondo-Robles, Laura</creatorcontrib><creatorcontrib>Mayo-Iscar, Agustín</creatorcontrib><creatorcontrib>Arenillas, Juan F.</creatorcontrib><creatorcontrib>NORDICTUS Investigators</creatorcontrib><creatorcontrib>on behalf of the NORDICTUS Investigators</creatorcontrib><title>Delayed Neurological Improvement After Full Endovascular Reperfusion in Acute Anterior Circulation Ischemic Stroke</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>We aimed to determine the prevalence and predictors of delayed neurological improvement (DNI) after complete endovascular reperfusion in anterior circulation acute ischemic stroke (AIS).
Retrospective analysis of an online multicenter prospective reperfusion registry of patients with consecutive anterior circulation AIS treated with endovascular thrombectomy (EVT) from January 2018 to June 2019 in tertiary stroke centers of the NORDICTUS (NORD-Spain Network for Research and Innovation in ICTUS) network. We included patients with AIS with a proximal occlusion in whom a modified Thrombolysis in Cerebral Infarction 3 reperfusion pattern was obtained. DNI was defined if, despite absence of early neurological improvement during the first 24 hours, patients achieved functional independence on day 90. Clinical and radiological variables obtained before EVT were analyzed as potential predictors of DNI.
Of 1565 patients with consecutive AIS treated with EVT, 1381 had proximal anterior circulation occlusions, 803 (58%) of whom achieved a modified Thrombolysis in Cerebral Infarction 3. Of these, 628 patients fulfilled all selection criteria and were included in the study. Mean age was 73.8 years, 323 (51.4%) were female, and median baseline National Institutes of Health Stroke Scale was 16. Absence of early neurological improvement was observed in 142 (22.6%) patients; 32 of these (22.5%) achieved good long-term outcome and constitute the DNI group. Predictors of DNI in multivariable-adjusted logistic regression were male sex (odds ratio, 6.4 [95% CI, 2.1–22.3] P=0.002), lower pre-EVT National Institutes of Health Stroke Scale score (odds ratio, 1.4 [95% CI, 1.2–1.5], P<0.001), and intravenous thrombolysis (odds ratio, 9.1 [95% CI, 2.7–30.90], P<0.001).
One-quarter of patients with anterior circulation AIS who do not clinically improve within the first 24 hours after complete cerebral endovascular recanalization will achieve long-term functional independence, regardless of the poor early clinical course. Male sex, lower initial clinical severity, and use of intravenous thrombolysis before EVT predicted this clinical pattern.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain Ischemia - diagnostic imaging</subject><subject>Brain Ischemia - surgery</subject><subject>Cerebral Revascularization - methods</subject><subject>Cerebral Revascularization - trends</subject><subject>Endovascular Procedures - methods</subject><subject>Endovascular Procedures - trends</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Ischemic Stroke - diagnostic imaging</subject><subject>Ischemic Stroke - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nervous System Diseases - diagnostic imaging</subject><subject>Nervous System Diseases - surgery</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Retrospective Studies</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1P3DAQhq2qFSyUf1BVPvaSZfyRDx-j7QIrUJFg75bjTLopTry1ExD_Hq-W0pM19vPOyM8Q8o3BkrGCXT5uH-5v1_VNvWQcliA4FMUnsmA5l5ksePWZLACEyrhU6pScxfgHALio8hNyKiQwxkq-IOEnOvOKLf2Fc_DO_-6tcXQz7IN_xgHHidbdhIFezc7R9dj6ZxPt7EygD7jH0M2x9yPtR1rbeUJajwnufaCrPhyw6fC6iXaHQ2_p4xT8E34lXzrjIl68n-dke7Xerm6yu_vrzaq-y6xQlcwwh7xpjFWiBdkqJQtrO2lY01atrSpkMhfSyJIlSkGuCtGUUpZdwXNhsRLn5MexbfrK3xnjpIc-WnTOjOjnqHnOlUrqKkioPKI2-BgDdnof-sGEV81AH2TrD9k6JfRRdop9f58wNwO2H6F_dv_3ffEueYlPbn7BoHdo3LTTaR1QFiVkHDiDMlXZ4UqKNyfDjDI</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Talavera, Blanca</creator><creator>Gómez-Vicente, Beatriz</creator><creator>Martínez-Galdámez, Mario</creator><creator>López-Cancio, Elena</creator><creator>García-Cabo, Carmen</creator><creator>Castellanos, Mar</creator><creator>Roel, Alexia</creator><creator>Tejada-Meza, Herbert</creator><creator>Marta-Moreno, Javier</creator><creator>Pérez-Lázaro, Cristina</creator><creator>Navarro-Pérez, María Pilar</creator><creator>Bravo-Anguiano, Yolanda</creator><creator>Bártulos-Iglesias, Mónica</creator><creator>Tejada-García, Javier</creator><creator>Rodrigo-Stevens, Gabriela</creator><creator>Martínez-Zabaleta, Maite</creator><creator>de la Riva, Patricia</creator><creator>Timiraos-Fernández, Juan José</creator><creator>del Mar Freijo, María</creator><creator>Luna, Alain</creator><creator>García-Sánchez, Juan Manuel</creator><creator>del Carmen Gil-Alzueta, María</creator><creator>Palacio-Portilla, Enrique Jesús</creator><creator>Jiménez-López, Yésica</creator><creator>López-Mesonero, Luis</creator><creator>Redondo-Robles, Laura</creator><creator>Mayo-Iscar, Agustín</creator><creator>Arenillas, Juan F.</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0951-6508</orcidid><orcidid>https://orcid.org/0000-0001-5757-9074</orcidid><orcidid>https://orcid.org/0000-0001-6542-868X</orcidid><orcidid>https://orcid.org/0000-0001-7444-0074</orcidid><orcidid>https://orcid.org/0000-0002-2019-598X</orcidid><orcidid>https://orcid.org/0000-0002-6506-1037</orcidid><orcidid>https://orcid.org/0000-0003-0012-9747</orcidid><orcidid>https://orcid.org/0000-0001-7464-6101</orcidid><orcidid>https://orcid.org/0000-0003-3116-1352</orcidid><orcidid>https://orcid.org/0000-0003-3574-3034</orcidid><orcidid>https://orcid.org/0000-0001-6370-218X</orcidid><orcidid>https://orcid.org/0000-0002-8024-4712</orcidid></search><sort><creationdate>20210701</creationdate><title>Delayed Neurological Improvement After Full Endovascular Reperfusion in Acute Anterior Circulation Ischemic Stroke</title><author>Talavera, Blanca ; Gómez-Vicente, Beatriz ; Martínez-Galdámez, Mario ; López-Cancio, Elena ; García-Cabo, Carmen ; Castellanos, Mar ; Roel, Alexia ; Tejada-Meza, Herbert ; Marta-Moreno, Javier ; Pérez-Lázaro, Cristina ; Navarro-Pérez, María Pilar ; Bravo-Anguiano, Yolanda ; Bártulos-Iglesias, Mónica ; Tejada-García, Javier ; Rodrigo-Stevens, Gabriela ; Martínez-Zabaleta, Maite ; de la Riva, Patricia ; Timiraos-Fernández, Juan José ; del Mar Freijo, María ; Luna, Alain ; García-Sánchez, Juan Manuel ; del Carmen Gil-Alzueta, María ; Palacio-Portilla, Enrique Jesús ; Jiménez-López, Yésica ; López-Mesonero, Luis ; Redondo-Robles, Laura ; Mayo-Iscar, Agustín ; Arenillas, Juan F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3984-e505bbac93d04d9946ccf4a1bd8dc88e14534a4715bb905963b7447f6253ce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain Ischemia - diagnostic imaging</topic><topic>Brain Ischemia - surgery</topic><topic>Cerebral Revascularization - methods</topic><topic>Cerebral Revascularization - trends</topic><topic>Endovascular Procedures - methods</topic><topic>Endovascular Procedures - trends</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Ischemic Stroke - diagnostic imaging</topic><topic>Ischemic Stroke - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nervous System Diseases - diagnostic imaging</topic><topic>Nervous System Diseases - surgery</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talavera, Blanca</creatorcontrib><creatorcontrib>Gómez-Vicente, Beatriz</creatorcontrib><creatorcontrib>Martínez-Galdámez, Mario</creatorcontrib><creatorcontrib>López-Cancio, Elena</creatorcontrib><creatorcontrib>García-Cabo, Carmen</creatorcontrib><creatorcontrib>Castellanos, Mar</creatorcontrib><creatorcontrib>Roel, Alexia</creatorcontrib><creatorcontrib>Tejada-Meza, Herbert</creatorcontrib><creatorcontrib>Marta-Moreno, Javier</creatorcontrib><creatorcontrib>Pérez-Lázaro, Cristina</creatorcontrib><creatorcontrib>Navarro-Pérez, María Pilar</creatorcontrib><creatorcontrib>Bravo-Anguiano, Yolanda</creatorcontrib><creatorcontrib>Bártulos-Iglesias, Mónica</creatorcontrib><creatorcontrib>Tejada-García, Javier</creatorcontrib><creatorcontrib>Rodrigo-Stevens, Gabriela</creatorcontrib><creatorcontrib>Martínez-Zabaleta, Maite</creatorcontrib><creatorcontrib>de la Riva, Patricia</creatorcontrib><creatorcontrib>Timiraos-Fernández, Juan José</creatorcontrib><creatorcontrib>del Mar Freijo, María</creatorcontrib><creatorcontrib>Luna, Alain</creatorcontrib><creatorcontrib>García-Sánchez, Juan Manuel</creatorcontrib><creatorcontrib>del Carmen Gil-Alzueta, María</creatorcontrib><creatorcontrib>Palacio-Portilla, Enrique Jesús</creatorcontrib><creatorcontrib>Jiménez-López, Yésica</creatorcontrib><creatorcontrib>López-Mesonero, Luis</creatorcontrib><creatorcontrib>Redondo-Robles, Laura</creatorcontrib><creatorcontrib>Mayo-Iscar, Agustín</creatorcontrib><creatorcontrib>Arenillas, Juan F.</creatorcontrib><creatorcontrib>NORDICTUS Investigators</creatorcontrib><creatorcontrib>on behalf of the NORDICTUS Investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talavera, Blanca</au><au>Gómez-Vicente, Beatriz</au><au>Martínez-Galdámez, Mario</au><au>López-Cancio, Elena</au><au>García-Cabo, Carmen</au><au>Castellanos, Mar</au><au>Roel, Alexia</au><au>Tejada-Meza, Herbert</au><au>Marta-Moreno, Javier</au><au>Pérez-Lázaro, Cristina</au><au>Navarro-Pérez, María Pilar</au><au>Bravo-Anguiano, Yolanda</au><au>Bártulos-Iglesias, Mónica</au><au>Tejada-García, Javier</au><au>Rodrigo-Stevens, Gabriela</au><au>Martínez-Zabaleta, Maite</au><au>de la Riva, Patricia</au><au>Timiraos-Fernández, Juan José</au><au>del Mar Freijo, María</au><au>Luna, Alain</au><au>García-Sánchez, Juan Manuel</au><au>del Carmen Gil-Alzueta, María</au><au>Palacio-Portilla, Enrique Jesús</au><au>Jiménez-López, Yésica</au><au>López-Mesonero, Luis</au><au>Redondo-Robles, Laura</au><au>Mayo-Iscar, Agustín</au><au>Arenillas, Juan F.</au><aucorp>NORDICTUS Investigators</aucorp><aucorp>on behalf of the NORDICTUS Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delayed Neurological Improvement After Full Endovascular Reperfusion in Acute Anterior Circulation Ischemic Stroke</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>52</volume><issue>7</issue><spage>2210</spage><epage>2217</epage><pages>2210-2217</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>We aimed to determine the prevalence and predictors of delayed neurological improvement (DNI) after complete endovascular reperfusion in anterior circulation acute ischemic stroke (AIS).
Retrospective analysis of an online multicenter prospective reperfusion registry of patients with consecutive anterior circulation AIS treated with endovascular thrombectomy (EVT) from January 2018 to June 2019 in tertiary stroke centers of the NORDICTUS (NORD-Spain Network for Research and Innovation in ICTUS) network. We included patients with AIS with a proximal occlusion in whom a modified Thrombolysis in Cerebral Infarction 3 reperfusion pattern was obtained. DNI was defined if, despite absence of early neurological improvement during the first 24 hours, patients achieved functional independence on day 90. Clinical and radiological variables obtained before EVT were analyzed as potential predictors of DNI.
Of 1565 patients with consecutive AIS treated with EVT, 1381 had proximal anterior circulation occlusions, 803 (58%) of whom achieved a modified Thrombolysis in Cerebral Infarction 3. Of these, 628 patients fulfilled all selection criteria and were included in the study. Mean age was 73.8 years, 323 (51.4%) were female, and median baseline National Institutes of Health Stroke Scale was 16. Absence of early neurological improvement was observed in 142 (22.6%) patients; 32 of these (22.5%) achieved good long-term outcome and constitute the DNI group. Predictors of DNI in multivariable-adjusted logistic regression were male sex (odds ratio, 6.4 [95% CI, 2.1–22.3] P=0.002), lower pre-EVT National Institutes of Health Stroke Scale score (odds ratio, 1.4 [95% CI, 1.2–1.5], P<0.001), and intravenous thrombolysis (odds ratio, 9.1 [95% CI, 2.7–30.90], P<0.001).
One-quarter of patients with anterior circulation AIS who do not clinically improve within the first 24 hours after complete cerebral endovascular recanalization will achieve long-term functional independence, regardless of the poor early clinical course. Male sex, lower initial clinical severity, and use of intravenous thrombolysis before EVT predicted this clinical pattern.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34011172</pmid><doi>10.1161/STROKEAHA.120.032066</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0951-6508</orcidid><orcidid>https://orcid.org/0000-0001-5757-9074</orcidid><orcidid>https://orcid.org/0000-0001-6542-868X</orcidid><orcidid>https://orcid.org/0000-0001-7444-0074</orcidid><orcidid>https://orcid.org/0000-0002-2019-598X</orcidid><orcidid>https://orcid.org/0000-0002-6506-1037</orcidid><orcidid>https://orcid.org/0000-0003-0012-9747</orcidid><orcidid>https://orcid.org/0000-0001-7464-6101</orcidid><orcidid>https://orcid.org/0000-0003-3116-1352</orcidid><orcidid>https://orcid.org/0000-0003-3574-3034</orcidid><orcidid>https://orcid.org/0000-0001-6370-218X</orcidid><orcidid>https://orcid.org/0000-0002-8024-4712</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-2499 |
| ispartof | Stroke (1970), 2021-07, Vol.52 (7), p.2210-2217 |
| issn | 0039-2499 1524-4628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2529912080 |
| source | MEDLINE; American Heart Association; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Brain Ischemia - diagnostic imaging Brain Ischemia - surgery Cerebral Revascularization - methods Cerebral Revascularization - trends Endovascular Procedures - methods Endovascular Procedures - trends Female Follow-Up Studies Humans Ischemic Stroke - diagnostic imaging Ischemic Stroke - surgery Male Middle Aged Nervous System Diseases - diagnostic imaging Nervous System Diseases - surgery Prospective Studies Registries Retrospective Studies |
| title | Delayed Neurological Improvement After Full Endovascular Reperfusion in Acute Anterior Circulation Ischemic Stroke |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T00%3A46%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Delayed%20Neurological%20Improvement%20After%20Full%20Endovascular%20Reperfusion%20in%20Acute%20Anterior%20Circulation%20Ischemic%20Stroke&rft.jtitle=Stroke%20(1970)&rft.au=Talavera,%20Blanca&rft.aucorp=NORDICTUS%20Investigators&rft.date=2021-07-01&rft.volume=52&rft.issue=7&rft.spage=2210&rft.epage=2217&rft.pages=2210-2217&rft.issn=0039-2499&rft.eissn=1524-4628&rft_id=info:doi/10.1161/STROKEAHA.120.032066&rft_dat=%3Cproquest_cross%3E2529912080%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2529912080&rft_id=info:pmid/34011172&rfr_iscdi=true |