MicroRNA‐124 regulates lens epithelial cell apoptosis by affecting Fas alternative splicing by targeting polypyrimidine tract‐binding protein in age‐related cataract

Background Age‐related cataract (ARC) is a primary cause of visual blindness worldwide. Lens epithelial cell (LEC) apoptosis, in which Fas plays an essential role, is a vital cytological basis for cataractogenesis. However, the regulatory mechanism of Fas‐dependent LEC apoptosis is not well understo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical & experimental ophthalmology 2021-08, Vol.49 (6), p.591-605
Hauptverfasser:	Zhang, Kaiyun, Yin, Yue, Pei, Cheng, Wu, Changrui
Format:	Artikel
Sprache:	eng
Schlagworte:	age‐related cataract Alternative Splicing Apoptosis Blindness Cataract - genetics Cataracts Cell Line Cell lines Cornea Epithelial Cells Fas fas Receptor - genetics Flow cytometry Gel electrophoresis Gene expression Humans Hydrogen peroxide Isoforms Lens, Crystalline MicroRNAs MicroRNAs - genetics microRNA‐124 miRNA Polyacrylamide Polymerase chain reaction Polypyrimidine Tract-Binding Protein PTB Reverse transcription RNA alternative splicing Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!