Characterization of Opalescence in low Volume Monoclonal Antibody Solutions Enabled by Microscale Nephelometry

Monoclonal antibody (mAb)-based drugs are often prone to unfavorable solution behaviors including high viscosity, opalescence, phase separation, and aggregation at the high concentrations needed to enable patient-centric subcutaneous dosage forms. Given that these can have a detrimental impact on ma...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of pharmaceutical sciences 2021-09, Vol.110 (9), p.3176-3182
Hauptverfasser:	Kingsbury, Jonathan S., Lantz, Michaela M., Saini, Amandeep, Wang, Michael Z., Gokarn, Yatin R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - analysis Biopharmaceutical characterization High concentration Immunoglobulin G Iridescence Monoclonal antibody Nephelometry Nephelometry and Turbidimetry Solutions Viscosity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!