Utilizing Solid-State Techniques and Accelerated Conditions to Understand Particle Size Instability in Inhaled Drug Substances

Micronization by air jet milling is often used to produce drug substance particles of acceptable respirable size for use in dry powder inhaler formulations. The energy from this process often induces surface disordered sites on the micronized particles with potential consequences for the long-term s...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2021-08, Vol.110 (8), p.3037-3046
Hauptverfasser:	Dobson, Daniel P., Yanez, Evelyn, Lubach, Joseph W., Stumpf, Andreas, Pellet, Jackson, Tso, Jerry
Format:	Artikel
Sprache:	eng
Schlagworte:	Accelerated Stability Crystallization Dry Powder Inhaler Micronization Particle Size Fusion Respirable Size
Online-Zugang:	Volltext
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